Case report: immune and inflammatory response to nutritional blend (ImmuneRecov®) supplementation in a 5-km runner
DOI:
https://doi.org/10.34117/bjdv11n12-091Keywords:
immune modulation, sports nutrition, cytokines, recovery, performanceAbstract
Daily supplementation with ImmuneRecov® has been hypothesized to modulate inflammation and support immune balance in athletes. Preclinical evidence demonstrated that the same nutritional blend suppressed IL-1β and IL-6 while enhancing IL-10 and IFN-γ expression in bronchial epithelial cells exposed to SARS-CoV-2, reinforcing its potential immunomodulatory properties. This case report describes the effects of a four-month supplementation protocol in a recreational runner, with assessments of inflammatory biomarkers, muscle damage markers, hematological profile, body composition, and perceived effort. The intervention was associated with transient inflammatory peaks after intense training, followed by progressive increases in anti-inflammatory cytokines and normalization of hematological parameters, suggesting a modulatory effect of ImmuneRecov® on immune response and recovery. These findings support the plausibility of nutritional strategies targeting immune homeostasis in sports, though larger controlled studies are required.
References
ANTONANGELI, F.; SORIANI, A.; SICCARDI, A. G. et al. A Nutritional Blend Suppresses the Inflammatory Response from Bronchial Epithelial Cells Induced by SARS-CoV-2. Nutrients, v. 14, n. 15, p. 3182, 2022. DOI: 10.3390/nu14153182. Disponível em: <https://doi.org/10.3390/nu14153182>. Acesso em: 13 dez. 2025.
CERQUEIRA, É.; MARINHO, D. A.; NEIVA, H. P. et al. Inflammatory effects of high and moderate intensity exercise - A systematic review. Frontiers in Physiology, v. 10, p. 1550, 2020. DOI: 10.3389/fphys.2019.01550. Disponível em: <https://doi.org/10.3389/fphys.2019.01550>. Acesso em: 13 dez. 2025.
FATOUROS, I. G.; JAMURTAS, A. Z. Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance. Journal of Inflammation Research, v. 9, p. 175-186, 2016. DOI: 10.2147/JIR.S114635. Disponível em: <https://doi.org/10.2147/JIR.S114635>. Acesso em: 13 dez. 2025.
NASH, D.; HUGHES, M. G.; BUTCHER, L. et al. IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance. Scandinavian Journal of Medicine & Science in Sports, v. 33, n. 1, p. 4-19, 2023. DOI: 10.1111/sms.14241. Disponível em: <https://doi.org/10.1111/sms.14241>. Acesso em: 13 dez. 2025.
NIEMAN, D. C.; WENTZ, L. M. The compelling link between physical activity and the body's defense system. Journal of Sport and Health Science, v. 8, n. 3, p. 201-217, 2019. DOI: 10.1016/j.jshs.2018.09.009. Disponível em: <https://doi.org/10.1016/j.jshs.2018.09.009>. Acesso em: 13 dez. 2025.
PEAKE, J. M.; NEUBAUER, O.; DELLA GATTA, P. A. et al. Muscle damage and inflammation during recovery from exercise. Journal of Applied Physiology, v. 122, n. 3, p. 559-570, 2017. DOI: 10.1152/japplphysiol.00971.2016. Disponível em: <https://doi.org/1152/japplphysiol.00971.2016>. Acesso em: 13 dez. 2025.
RINGLEB, M.; JAVELLE, F.; HAUNHORST, S. et al. Acute resistance exercise-induced changes in IL-6, IL-10, and IL-1ra in healthy adults: a systematic review and meta-analysis. medRxiv, 2023. DOI: 10.1101/2023.05.10.23289790. Disponível em: <https://doi.org/10.1101/2023.05.10.23289790>. Acesso em: 13 dez. 2025.
SCHEFFER, D. L.; LATINI, A. Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1866, n. 10, p. 165823, 2020. DOI: 10.1016/j.bbadis.2020.165823. Disponível em: <https://doi.org/10.1016/j.bbadis.2020.165823>. Acesso em: 13 dez. 2025.
WALSH, N. P.; OLIVER, S. J. Exercise, immune function and respiratory infection: an update on the influence of training and environmental stress. Immunology and Cell Biology, v. 94, n. 2, p. 132-139, 2016. DOI: 10.1038/icb.2015.99. Disponível em: <https://doi.org/10.1038/icb.2015.99>. Acesso em: 13 dez. 2025.
WALSH, N. P. Nutrition and athlete immune health: new perspectives on an old paradigm. Sports Medicine, v. 49, suppl. 2, p. 153-168, 2019. DOI: 10.1007/s40279-019-01160-3. Disponível em: <https://doi.org/10.1007/s40279-019-01160-3>. Acesso em: 13 dez. 2025.
WARE JR, J. E.; SHERBOURNE, C. D. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Medical Care, v. 30, n. 6, p. 473-483, 1992. DOI: 10.1097/00005650-199206000-00002. Disponível em: <https://doi.org/10.1097/00005650-199206000-00002>. Acesso em: 13 dez. 2025.
V
