Population based screening for osteoporosis in men among 40 and 80 years in the brazilian state of Roraima"
DOI:
https://doi.org/10.34117/bjdv10n4-071Keywords:
men, osteoporsois, Frax, TBS score, fractureAbstract
The main objective of this study was to conduct population screening for osteoporosis in men between the ages of 40 and 80 in the Boa Vista, the capital of the Brazilian state of Roraima. The population study conducted in this study was basically based on the Fracture Risk Assessment Tool (FRAX®) nomogram model proposed by the World Health Organization (WHO). Specifically, the current work focuses on (i) analyzing the serum concentrations of calcium, vitamin D and total testosterone in relation to the risk of bone event by the FRAX® nomogram and (ii) correlating cardiovascular risk by calculating Framingham score with the FRAX® nomogram. This cohort, and cross-sectional study involves both quantitative and qualitative data obtained in the field from 380 patients. The data obtained were compared to the pre-existing data collected through different bibliography. For the sampling, a cluster method was utilized. Patients with immediate need of health services were referred to the state hospital of Coronel Mota, Boa Vista. This project was approved by the Ethical Committee (number: 50207115.7.0000.5301). While commuting to work or travel around found to be the major reason of the fractures, we observed that older people and people who were involved in physical activities inside a gymnasium had considerably high at risk of fractures. FRAX and TBS femur score (Trabecular Bone Score) was higher for people with fractures. People having lumbar osteopenia and femur osteopenia had higher risk of TBS femur fractures while people having lumbar osteoporosis had higher risk of TBS (femur and hip) as well as FRAX femur factures. All the data obtained in this study were analyzed using SPSS version 21 and a p value of ≤0.05 was considered as statistically significant. Key risk factors for fracture include increased age, physical activities in a gymnasium, lumbar and femur osteopenia and lumbar osteoporosis.
References
Kiebzak GM, Beinart GA, Perser K, Ambrose CG, Siff SJ, Heggeness MH. Undertreatment of osteoporosis in men with hip fracture. Arch Intern Med. 2002;162:2217-22.
Looker AC, Orwoll ES, Johnston CC Jr, Lindsay RL, Wahner HW, Dunn
WL, et al. Prevalence of low femoral bone density in older U.S. adults from
NHANES III. J Bone Miner Res. 1997;12:1761-8.
Nguyen TV, Eisman JA, Kelly PJ, Sambrook PN. Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol. 1996;144:255-63.
Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractutures. Osteoporos Int. 2006 Dec;17(12):1726-33.
Boskey AL, DiCarlo E, Paschalis E, West P, Mendelsohn R. Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation. Osteoporos Int. 2005;16:2031-8
De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman
JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: a meta‐analysis. Osteoporos Int. 2005;16(11):1330–8.
Kanis JA, Johnell O, Oden A, Johansson H, De Laet C, Eisman JA, Fujiwara S, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman A, Tenenhouse A. Smoking and fracture risk: a metaanalysis. Osteoporos Int. 2005;16(2):155–62.
Baron JA, Farahmand BY, Weiderpass E, Michaelsson K, Alberts A, Persson I, Ljunghall S. Cigarette smoking, alcohol consumption, and risk of hip fracture in women. Arch Intern Med. 2001;161(7):983–8.
Høidrup S, Sørensen TI, Strøger U, Lauritzen JB, Schroll M, Grønbaek M. Leisure‐time physical activity levels and changes in relation to risk of hip fracture in men and women.AmJ Epidemiol. 2001;154(1):60–8.
Feskanich D, Willett W, Colditz G. Walking and leisure‐time activity and risk of hip fracture in postmenopausal women. JAMA. 2002;288(18):2300–6.
Määttä M, Terho E, Jokinen H, Pulkkinen P, Korpelainen J, Heikkinen J, Keinänen‐Kiukaanniemi S, Jämsä T, Korpelainen R. Lifestyle factors and site‐specific risk of hip fracture in community dwelling older women ‐ a 13‐year prospective population‐based cohort study. BMC Musculoskelet Disord. 2012;13:173.
Mussolino ME, Looker AC, Madans JH, Langlois JA, Orwoll ES. Risk factors for hip fracture in white men: the NHANES I Epidemiologic Follow‐up Study. J Bone Miner Res. 1998;13(6):918–24.
Appleby PN, Allen NE, Roddam AW, Key TJ. Physical activity and fracture risk: a prospective study of 1898 incident fractures among 34,696 British men and women. J Bone Miner Metab. 2008; 26(2): 191–8.
Johnell O, Kanis JA (2004) An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int 15:897–902
Williams A (1999) Calculating the global burden of disease. Time for a strategic reappraisal. Health Econ 8:1–8
Turner CH, Pavalko FM. Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation. J Orthop Sci. 1998;3(6):346–55.
Shepherd AJ, Cass AR, Carlson CA, Ray L. Development and internal validation of the male osteoporosis risk estimation score. Ann Fam Med. 2007; 5:540-6.
