Computer aided design, synthesis and characterisation of thiazolidinedione acetic acid derivatives as brest- cancer inhibitors
DOI:
https://doi.org/10.34117/bjdv10n4-065Keywords:
thiazolidinedione acetic acid, anti-cancer, cadd, integrase inhibitors, pharmacophore modelsAbstract
The development of new anti-cancer drugs is a dynamic process that is continuously fueled, at the basic level, by the identification of new molecular targets for chemotherapeutic intervention, and, at the clinical level, by the problems (i.e. adherence, tolerability, toxicity, and virus-drug resistance) encountered with existing drugs. Thiazolidin-2,4-dione acetic acids are a class of heterocyclic compounds which possess the aforementioned pharmacophoric features. Thus several benzylidene-thiazolidin-2,4-dione compounds were designed. A total number of 12 compounds were synthesized successfully with good purity. The structures of these compounds have been confirmed by IR & Mass spectrometry. In-vitro studies of the synthesized compounds are yet to be performed & it is expected that these studies will reflect the effectiveness of these molecules as barest cancer inhibitors and will open a new dimension for the synthesis of novel anti-cancer agents. The labile structure of the synthesized compounds allows the possibility of elaborating the present work by increasing the number of derivatives & by altering the positions of substitutions on the root nucleus followed by SAR & QSAR studies. Moreover, compounds of similar nature can be designed which will lead to the synthesis of many more structural analogues.
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