Brittle Asthma -What next in management?
DOI:
https://doi.org/10.34117/bjdv10n4-063Keywords:
brittle asthma, atopy, terbutaline, adrenalineAbstract
The term ‘brittle asthma’ was first used by Turner-Warwick (1977) to describe patients with asthma whose peak expiratory flow (PEF) varied ‘chaotically’ (follow no set pattern); which could lead to death from an a cute severe attack. Morbidity from brittle asthma is considerable, and we aim to identify causes and management strategies for such patients. Two types of Brittle asthma has been suggested; a feature of both types being a susceptibility to repeated severe attacks resulting in hospitalization & considerable morbidity and mortality. Data from asthma register (UK), suggests that the prevalence is the order of 0.05% of all asthmatics.
References
GUPTA D, AYRES JG (2001). "Brittle asthma: a separate clinical phenotype of asthma?". Indian J Ches t Dis Allied Sci. 43 (1): 33–8. PMID 11370504.
GRAZIANI E, PETROIANNI A, TERZANO C (2004). "Brittle asthma". Eur Rev Med Pharmacol Sci. 8 (4): 135–8. PMID 15636398.
OGORODOVA LM, SELIVANOVA PA, GERENG EA, BOGOMIAKOV VS, VOLKOVA LI, PLESHKO RI (2008). "[Path omorphological characteristics of unstable bronchial asthma (brittle phenotype)]". Ter. Arkh. (in Russian). 80 (3): 39–43. PMID 18441682.
SAUNDERS (2005). "Asthma". In Homer A. Boushey Jr., M.D.; David B. Corry, M.D.; John V. Fahy, M. D.; Esteban G. Burchard, M.D.; Prescott G. Woodruff, M.D.; et al. (eds.). Mason: Murray & Nadel's Textbo ok of Respiratory Medicine (4th ed.). Elsevier.
TOUNGOUSSOVA O, FOSCHINO BARBARO MP, ESPOSITO LM, et al. (June 2007). "Brittle asthma". Monaldi Arch Chest Dis. 67 (2): 102–5. doi:10.4081/monaldi.2007.497. PMID 17695694.
WALDRON, Jill (2007). Asthma Care in the Community. Wiley-Interscience. p. 122. ISBN 978-0-470-03000-4.

