Atividade antibiofilme de micropartículas de óxido de zinco sintetizadas biologicamente
DOI:
https://doi.org/10.34117/bjdv9n7-112Keywords:
espinafre Nova Zelândia, biofilmes, bactérias, resistência aos antimicrobianosAbstract
As infecções bacterianas são importantes causas de alta morbi-mortalidade, incluindo as causadas por bactérias multirresistentes aos antimicrobianos. Além disso, determinadas bactérias são capazes de formar biofilme, o que dificulta o tratamento, visto que estas formações são mais tolerantes e resistentes aos antimicrobianos convencionais. As micropartículas de óxido de zinco (ZnOMPs) se destacam por apresentarem potencial ação antimicrobiana, além de serem menos tóxicas e apresentarem baixo custo de produção. Nesse estudo, ZnOMPs foram sintetizadas biologicamente, utilizando extrato de espinafre Nova Zelândia (Tetragonia tetragonioides), e caracterizadas quanto ao tamanho e potencial zeta das partículas. A ação antibacteriana foi avaliada pela determinação da concentração inibitória mínima (CIM) contra as bactérias Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa. Também foi avaliada a atividade inibitória na formação do biofilme e antibiofilme maduro, produzido por E. coli enteroagregativa. As ZnOMPs apresentaram ação antibacteriana para todas as bactérias testadas, com as CIMs variando de 203 a 814 μg.mL-1. As ZnOMPs foram mais eficazes na inibição de biofilme em formação do que para biofilme maduro. Baseados nesses resultados, as ZnOMPs biogênicas apresentam potencial para o controle de infecções bacterianas.
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