Paracoccidioidomycosis in a 64-year-old man: a case report
DOI:
https://doi.org/10.34117/bjdv9n1-339Keywords:
Paracoccidioidomycosis, systemic mycosis, mulberry-like lesionAbstract
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the thermo-dependent dimorphic fungus Paracoccidioides spp, limited to the American continent, but with a high incidence in Brazil, mainly in the Midwest, South and Southeast regions. This is a case report of a 64-year-old male patient that was referredat a hospital, complaining of pain in the mouth and dysphagia. The patient presented multiple and finely granular hemorrhagic pinpoint erosions with a mulberry-like appearance in oral mucosa. The patient underwent an incisional biopsy, and the histopathological analyses confirmed the presence of the fungus and the diagnosis of PCM. Lesions in oral mucosa may be the first visible clinical manifestation of PCM; so, a meticulous evaluation of oral cavity and well-conducted diagnostic techniques are indispensable for a correct diagnosis and an appropriate therapy of PCM.
References
MUÑOZ JF., FARRER RA., DESJARDINS CA., et al. Genome Diversity, Recombination, and Virulence across the Major Lineages of Paracoccidioides. MSphere. 2016.
SHIKANAI-YASUDA MA., MENDES RP., COLOMBO AL., et al. II Consenso Brasileiro em Paracoccidioidomicose - 2017. vol. 27. 2018.
MARTINEZ R. New trends in paracoccidioidomycosis epidemiology. J Fungi. 2017.
PARDINI A., MOREIRA V. Paracoccidioidomicose: histórico, etiologia, epidemiologia, patogênese, formas clínicas, diagnóstico laboratorial e antígenos. Bol Epidemiológico Paul. 2008.
DORNELA VERLI F., APARECIDA MARINHO S., CORREA DE SOUZA S., ZANCANARO DE FIGUEIREDO MA., SOARES YURGEL L. Clinical-epidemiologic profile of paracoccidioidomycosis at the Stomatology Department of São Lucas Hospital, Pontificia Universidade Católica of Rio Grande do Sul. Rev Soc Bras Med Trop. 2005.
BRAZÃO-SILVA MT., ANDRADE MF., FRANCO T., et al. Paracoccidioidomycosis: A series of 66 patients with oral lesions from an endemic area. Mycoses. 2011.
DE ARRUDA JAA., SCHUCH LF., ABREU LG., et al. A multicentre study of oral paracoccidioidomycosis: Analysis of 320 cases and literature review. Oral Dis. 2018.
TEIXEIRA MM., THEODORO RC., NINO-VEGA G., BAGAGLI E., FELIPE MSS. Paracoccidioides Species Complex: Ecology, Phylogeny, Sexual Reproduction, and Virulence. PLoS Pathog. 2014.
BORTOLUZZI MC., ROSSI T., MANFRO R., ARMÊNIO MF. Oral manifestations of paracoccidioidomycosis : a report of two cases Manifestações bucais da paracoccidiomicose : relato de dois casos. 2008.
FRANCESCONI DO VALLE AC., MARQUES DE MACEDO P., ALMEIDA-PAES R., ROMÃO AR., Dos Santos Lazéra M., Wanke B. Paracoccidioidomycosis after highway construction, Rio de Janeiro, Brazil. Emerg Infect Dis. 2017.
THEODORO RC., TEIXEIRA M DE M., FELIPE MSS., et al. Genus Paracoccidioides: Species recognition and biogeographic aspects. PLoS One. 2012.
TURISSINI DA., GOMEZ OM., TEIXEIRA MM., MCEWEN JG., MATUTE DR. Species boundaries in the human pathogen Paracoccidioides. Fungal Genet Biol. 2017.
DE MACEDO PM., DE MELO TEIXEIRA M., BARKER BM., ZANCOPÉ-OLIVEIRA RM., ALMEIDA-PAES R., DO VALLE ACF. Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana. PLoS Negl Trop Dis. 2019.
SHANKAR J., RESTREPO A., CLEMONS K V., STEVENS DA. Hormones and the resistance of women to paracoccidioidomycosis. Clin Microbiol Rev. 2011.
AZEVEDO RS., GOUVA AF., LOPES MA., CORRA MB., JORGE J. Synchronous oral paracoccidioidomycosis and oral squamous cell carcinomas with submandibular enlargement. Med Mycol. 2010.
LANIADO-LABORÍN R., CABRALES-VARGAS MN. Amphotericin B: side effects and toxicity. Rev Iberoam Micol. 2009.
BARRATT G., BRETAGNE S. Optimizing efficacy of Amphotericin B through nanomodification. Int J Nanomedicine. 2007.
BRAJTBURG J., BOLARD J. Carrier effects on biological activity of amphotericin B. Clin Microbiol Rev. 1996.
ELLIS D. Amphotericin B: Spectrum and resistance. J Antimicrob Chemother. 2002.
