Chia seed mucilage (<em>Salvia hispanica</em> L.): An emerging biopolymer for industrial application
DOI:
https://doi.org/10.34117/bjdv9n1-154Keywords:
chia seed mucilage, technological properties, biological activities, applicationsAbstract
Biopolymers are widely distributed in nature and have a wide variety of biological properties and applications. Chia (Salvia hispanica L.) is an herbaceous plant that belongs to the Lamiaceae family, which when in contact with water exude the fraction of soluble fiber in the form of mucilage. In view of the above, this study aims to provide an overview of the characteristics and applications of chia mucilage that make it a biopolymer of industrial interest. The data collection was carried out in the databases: SciELO (Scientific Electronic Library Online), Science Direct, MDPI, Wiley Online Library, Springer and Periodical capes using the following descriptors: “Chia Seed Mucilage”, “Technological Properties”, “Biological Activities”, and “Applications” in alone and in association. After the critical analysis of the selected articles, it was possible to conclude that the chia mucilage has numerous and unique physical-chemical, chemical and technological properties. Applications in the food field are among the most used in view of the industrial perspective. However, the infinite potential that this biomaterial has for the pharmaceutical and agricultural industries is undeniable.
References
Liu, L., Li, M., Yu, M., Shen, M., Wang, Q., Yu, Y., & Xie, J. Natural polysaccharides exhibit anti-tumor activity by targeting gut microbiota. International journal of biological macromolecules, 121, 743-751, 2019.
Li, C., Li, X., You, L., Fu, X., & Liu, R. H. Fractionation, preliminary structural characterization and bioactivities of polysaccharides from Sargassum pallidum. Carbohydrate polymers, 155, 261-270, 2017.
Yu, Y., Shen, M., Song, Q., & Xie, J. Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review. Carbohydrate polymers, 183, 91-101, 2018,
Shi, L. Bioactivities, isolation and purification methods of polysaccharides from natural products: A review. International journal of biological macromolecules, 92, 37-48, 2016.
Xie, J. H., Zhang, F., Wang, Z. J., Shen, M. Y., Nie, S. P., & Xie, M. Y. Preparation, characterization and antioxidant activities of acetylated polysaccharides from Cyclocarya paliurus leaves. Carbohydrate Polymers, 133, 596-604, 2015.
Xie, J. H., Wang, Z. J., Shen, M. Y., Nie, S. P., Gong, B., Li, H. S., ... & Xie, M. Y. Sulfated modification, characterization and antioxidant activities of polysaccharide from Cyclocarya paliurus. Food Hydrocolloids, 53, 7-15, 2016.
Meng, X., Liang, H., & Luo, L. Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities. Carbohydrate research, 424, 30-41, 2016.
Xie, J. H., Liu, X., Shen, M. Y., Nie, S. P., Zhang, H., Li, C., ... & Xie, M. Y. Purification, physicochemical characterisation and anticancer activity of a polysaccharide from Cyclocarya paliurus leaves. Food Chemistry, 136(3-4), 1453-1460, 2013.
Liu, X., Xie, J., Jia, S., Huang, L., Wang, Z., Li, C., & Xie, M. Immunomodulatory effects of an acetylated Cyclocarya paliurus polysaccharide on murine macrophages RAW264. 7. International journal of biological macromolecules, 98, 576-581, 2017.
Chavan, V. R., Gadhe, K. S., Dipak, S., & Hingade, S. (2017). Studies on extraction and utilization of chia seed gel in ice cream as a stabilizer. Journal of Pharmacognosy and Phytochemistry, 6(5), 1367-1370, 2017.
Fernandes, S. S., & Salas-Mellado, M. de las M. Addition of chia seed mucilage for reduction of fat content in bread and cakes. Food Chemistry, 227, 237–244, 2017.
Câmara, A. K. F. I., Okuro, P. K., da Cunha, R. L., Herrero, A. M., Ruiz-Capillas, C., & Pollonio, M. A. R. Chia (Salvia hispanica L.) mucilage as a new fat substitute in emulsified meat products: Technological, physicochemical, and rheological characterization. LWT, 109193, 2020a.
Yu, Z., Alsammarraie, F. K., Nayigiziki, F. X., Wang, W., Vardhanabhuti, B., Mustapha, A., & Lin, M. Effect and mechanism of cellulose nanofibrils on the active functions of biopolymer-based nanocomposite films. Food Research International, 99, 166-172, 2017.
Busch, V. M., Delgado, J. F., Santagapita, P. R., Wagner, J. R., & Buera, M. D. P. Rheological characterization of vinal gum, a galactomannan extracted from Prosopis ruscifolia seeds. Food Hydrocolloids, 74, 333-341,2018.
Martínez, M. L., Marín, M. A., Faller, C. M. S., Revol, J., Penci, M. C., & Ribotta, P. D. Chia (Salvia hispanica L.) oil extraction: Study of processing parameters. LWT-Food Science and Technology, 47(1), 78-82, 2012.
Muñoz, L. A., Cobos, A., Diaz, O., & Aguilera, J. M. Chia seeds: microstructure, mucilage extraction and hydration. Journal of food Engineering, 108(1), 216-224, 2012.
Alvites Misajel, K. C., Garcia Gutierrez, M., Miranda Rodríguez, C. L., & Ramos Escudero, F. Organically vs conventionally-grown dark and white chia seeds (Salvia hispanica L.): fatty acid composition, antioxidant activity and techno-functional properties. International Journal of Fats and Oils. 70(2), 2019.
Maruyama, S. A., Claus, T., Chiavelli, L. U., Bertozzi, J., Pilau, E. J., Souza, N. E. D., ... & Matsushita, M. Analysis of carotenoids, α-tocopherol, sterols and phenolic compounds from white bread enriched with chia (Salvia hispanica L.) seeds and carrot (Daucus carota L.) leaves. Journal of the Brazilian Chemical Society, 25(6), 1108-1115, 2014.
Hrnčič, M. K., Cör, D., & Knez, Ž. Subcritical extraction of oil from black and white chia seeds with n-propane and comparison with conventional techniques. The Journal of Supercritical Fluids, 140, 182-187, 2018.
Avila-De La Rosa, G., Alvarez-Ramirez, J., Vernon-Carter, E. J., CarrilloNavas, H., & Pérez-Alonso, C. Viscoelasticity of chia (Salvia hispanica L.) seed mucilage dispersion in the vicinity of an oil-water interface. Food Hydrocolloids, 49, 200-207, 2015.
Capitani, M. I., Corzo-Rios, L. J., Chel-Guerrero, L. A., Betancur-Ancona, D. A., Nolasco, S. M., & Tomás, M. C. Rheological properties of aqueous dispersions of chia (Salvia hispanica L.) mucilage. Journal of food engineering, 149, 70-77, 2015.
Dick, M., Costa, T. M. H., Gomaa, A., Subirade, M., de Oliveira Rios, A., & Flôres, S. H. Edible film production from chia seed mucilage: Effect of glycerol concentration on its physicochemical and mechanical properties. Carbohydrate polymers, 130, 198-205, 2015.
Timilsena, Y. P., Adhikari, R., Kasapis, S., & Adhikari, B. Molecular and functional characteristics of purified gum from Australian chia seeds. Carbohydrate polymers, 136, 128-136, 2016.
Munoz, L. A., Aguilera, J. M., Rodriguez-Turienzo, L., Cobos, A., & Diaz, O. Characterization and microstructure of films made from mucilage of salvia hispanica L. and whey protein concentrate. Journal of Food Engineering, 111(3), 511-518, 2012b.
Antigo, J. L. D., Bergamasco, R. D. C., & Madrona, G. S. How drying methods can influence the characteristics of mucilage obtained from chia seed and psyllium husk. Ciência Rural, 50(8), 2020a.
Lin, K. Y., Daniel, J. R., & Whistler, R. L. Structure of chia seed polysaccharide exudate. Carbohydrate polymers, 23(1), 13-18, 1994.
Velázquez-Gutiérrez, S. K., Figueira, A. C., Rodríguez-Huezo, M. E., Román-Guerrero, A., Carrillo-Navas, H., & Pérez-Alonso, C. Sorption isotherms, thermodynamic properties and glass transition temperature of mucilage extracted from chia seeds (Salvia hispanica L.). Carbohydrate polymers, 121, 411-419, 2015.
Lopes, A. C., Ribas, M. F., Tonial, I. B., & Lucchetta, L. Chia mucilage application (Salvia hispanica, l.) In biscuit processing.Brazilian Journal of Development, 6(4), 17997-18008, 2020.
Espinosa-Andrews, H., Urias-Silvas, J.E. Thermal properties of agave fructans (Agave tequilana Weber var. 581 Azul). Carbohydrate Polymers, 87, 2671-2676, 2012.
Pathak, P. O., Nagarsenker, M. S., Barhate, C. R., Padhye, S. G., Dhawan, V. V., Bhattacharyya, D., ... & Fahr, A. Cholesterol anchored arabinogalactan for asialoglycoprotein receptor targeting: synthesis, characterization, and proof of concept of hepatospecific delivery. Carbohydrate research, 408, 33-43, 2015.
Campo, C., dos Santos, P. P., Costa, T. M. H., Paese, K., Guterres, S. S., Rios, A. de O., & Flôres, S. H. Nanoencapsulation of chia seed oil with chia mucilage (Salvia hispanica L.) as wall material: Characterization and stability evaluation. Food Chemistry, 234, 1–9, 2017.
Ixtaina, V. Y., Nolasco, S. M., & Tomas, M. C. Physical properties of chia (Salvia hispanica L.) seeds. Industrial crops and products, 28(3), 286-293, 2008.
Punia, S., & Dhull, S. B. Chia seed (Salvia hispanica L.) mucilage (a heteropolysaccharide): Functional, thermal, rheological behaviour and its utilization. International journal of biological macromolecules, 140, 1084-1090, 2019.
Capitani, M. I., Spotorno, V., Nolasco, S. M., & Tomás, M. C. Physicochemical and functional characterization of by-products from chia (Salvia hispanica L.) seeds of Argentina. LWT-Food Science and Technology, 45(1), 94-102, 2012.
Ramos, I. F.S., Magalhães, L. M., do O Pessoa, C., Ferreira, P. M. P., dos Santos Rizzo, M., Osajima, J. A., Silva-filho, E. C., Nunes, C., Raposo, F., Coimbra, M.A., Ribeiro, A. B.& Costa, M. P. New properties of chia seed mucilage (Salvia hispanica L.) and potential application in cosmetic and pharmaceutical products. Industrial Crops and Products, 171, 113981, 2021.
Mirhosseini, H., & Amid, B. T. A review study on chemical composition and molecular structure of newly plant gum exudates and seed gums. Food Research International, 46(1), 387-398, 2012.
Viebke, C., Al-Assaf, S., & Phillips, G. O. Food hydrocolloids and health claims. Bioactive Carbohydrates and Dietary Fibre, 4(2), 101-114, 2014.
Alpizar-Reyes, E.; Lpizar-Reyes, E.; Carrillo-Navas, H.; Gallardo-Rivera, R.; Varela-Guerrero, V.; Alvarez-Ramirez, J.; Pérez-Alonso, C. Functional properties and physicochemical characteristics of tamarind (Tamarindus indica L.) seed mucilage powder as a novel hydrocolloid. Journal of Food Engineering, 209, 68-75, 2017.
Li, J. M., & Nie, S. P. The functional and nutritional aspects of hydrocolloids in foods. Food Hydrocolloids, 53, 46-61, 2016.
Alfredo, V. O., Gabriel, R. R., Luis, C. G., & David, B. A. Physicochemical properties of a fibrous fraction from chia (Salvia hispanica L.). LWT-Food Science and Technology, 42(1), 168-173, 2009.
Câmara, A. K. F. I., Vidal, V. A. S., Santos, M., Bernardinelli, O. D., Sabadini, E., & Pollonio, M. A. R. Reducing phosphate in emulsified meat products by adding chia (Salvia hispanica L.) mucilage in powder or gel format: A clean label technological strategy. Meat science, 163, 108085, 2020b.
Hentry, H. S., Mittleman, M., & McCrohan, P. R. (1990). Introducción de la chía y la goma de tragacanto en los Estados Unidos. In J. Janick, & J. E. Simon (Eds.). Avances en Cosechas Nuevas (pp. 252–256). Portland, O: Prensa de la Madera.
Paula, M. M. D. O., Silva, J. R. G., Oliveira, K. L. D., Massingue, A. A., Ramos, E. M., Benevenuto Júnior, A. A., ... & Silva, V. R. O. Technological and sensory characteristics of hamburgers added with chia seed as fat replacer. Ciência Rural, 49(8), 2019.
Darwish, A. M., Khalifa, R. E., & El Sohaimy, S. A. Functional properties of chia seed mucilage supplemented in low fat yoghurt. Alexandria Science Exchange Journal, 39(July-September), 450-459, 2018.
Casenave, C., Dochain, D., Alvarez, G., Arellano, M., Benkhelifa, H., & Leducq, D. Model identification and reduction for the control of an ice cream crystallization process. Chemical Engineering Science, 119, 274-287, 2014.
Varela, P., Pintor, A., & Fiszman, S. How hydrocolloids affect the temporal oral perception of ice cream. Food hydrocolloids, 36, 220-228, 2014.
Malathi, A. N., Santhosh, K. S., & Nidoni, U. Recent trends of biodegradable polymer: biodegradable films for food packaging and application of nanotechnology in biodegradable food packaging. Current Trends in Technology and Science, 3(2), 73-79, 2014.
Patel, V., & Patel, S. Delivering drug‐polymer complex via quick dissolving film: A step towards the development of an appropriate pediatric formulation. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm, 7(1), 2014.
da Silva, I. S. V., de Sousa, R. M. F., de Oliveira, A., de Oliveira, W. J., Motta, L. A. C., Pasquini, D., & Otaguro, H. Polymeric blends of hydrocolloid from chia seeds/apple pectin with potential antioxidant for food packaging applications. Carbohydrate polymers, 202, 203-210, 2018.
Kuntzler, S. G., Costa, J. A. V., & de Morais, M. G. Development of electrospun nanofibers containing chitosan/PEO blend and phenolic compounds with antibacterial activity. International journal of biological macromolecules, 117, 800-806, 2018.
Baldwin, E. A., Hagenmaier, R., & Bai, J. (Eds.). Edible coatings and films to improve food quality. CRC press, 2011.
Mujtaba, M., Koc, B., Salaberria, A. M., Ilk, S., Cansaran-Duman, D., Akyuz, L., ... & Boufi, S. Production of novel chia-mucilage nanocomposite films with starch nanocrystals; An inclusive biological and physicochemical perspective. International journal of biological macromolecules, 133, 663-673, 2019.
Williams, P. A., & Phillips, G. O. Introduction to food hydrocolloids. In Handbook of hydrocolloids (pp. 3-26). Woodhead publishing, 2021.
Mohebbi, M., Ansarifar, E., Hasanpour, N., & Amiryousefi, M. R. Suitability of Aloe vera and gum tragacanth as edible coatings for extending the shelf life of button mushroom. Food and Bioprocess Technology, 5(8), 3193-3202, 2012.
Jouki, M., Khazaei, N., Ghasemlou, M., & HadiNezhad, M. Effect of glycerol concentration on edible film production from cress seed carbohydrate gum. Carbohydrate Polymers, 96(1), 39-46, 2013.
Beikzadeh, S., Khezerlou, A., Jafari, S. M., Pilevar, Z., & Mortazavian, A. M. Seed mucilages as the functional ingredients for biodegradable films and edible coatings in the food industry. Advances in colloid and interface science, 102164, 2020.
Charles-Rodríguez, A. V., Rivera-Solís, L. L., Martins, J. T., Genisheva, Z., Robledo-Olivo, A., González-Morales, S., ... & Flores-López, M. L. Edible films based on black chia (Salvia hispanica L.) seed mucilage containing Rhus microphylla fruit phenolic extract. Coatings, 10(4), 326, 2020.
Capitani, M. I., Matus-Basto, A., Ruiz-Ruiz, J. C., Santiago-García, J. L., Betancur-Ancona, D. A., Nolasco, S. M., ... & Segura-Campos, M. R. Characterization of biodegradable films based on Salvia hispanica L. protein and mucilage. Food and Bioprocess Technology, 9(8), 1276-1286, 2016.
Fernandes, S. S., Romani, V. P., da Silva Filipini, G., & G Martins, V. Chia seeds to develop new biodegradable polymers for food packaging: Properties and biodegradability. Polymer Engineering & Science, 60(9), 2214-2223, 2020.
Pan, Y., Li, X. M., Meng, R., & Zhang, B. Exploration of the stabilization mechanism and curcumin bioaccessibility of emulsions stabilized by whey protein hydrolysates after succinylation and glycation in different orders. Journal of agricultural and food chemistry, 68(2), 623-632, 2019.
Segura-Campos, M., Acosta-Chi, Z., Rosado-Rubio, G., Chel-Guerrero, L., & Betancur-Ancona, D. Whole and crushed nutlets of chia (Salvia hispanica L.) from Mexico as a source of functional gums. Food Science and Technology, 34(4), 701-709, 2014.
Antigo, J. L. D., Stafussa, A. P., de Cassia Bergamasco, R., & Madrona, G. S. Chia seed mucilage as a potential encapsulating agent of a natural food dye. Journal of Food Engineering, 285, 110101, 2020b.
Hernández-Nava, R., López-Malo, A., Palou, E., Ramírez-Corona, N., & Jiménez-Munguía, M. T. Encapsulation of oregano essential oil (Origanum vulgare) by complex coacervation between gelatin and chia mucilage and its properties after spray drying. Food Hydrocolloids, 109, 106077, 2020.
Martínez, M. L., Curti, M. I., Roccia, P., Llabot, J. M., Penci, M. C., Bodoira, R. M., & Ribotta, P. D. Oxidative stability of walnut (Juglans regia L.) and chia (Salvia hispanica L.) oils microencapsulated by spray drying. Powder Technology, 270, 271–277, 2015.
da Silva Stefani, F., de Campo, C., Paese, K., Guterres, S. S., Costa, T. M. H., & Flôres, S. H. Nanoencapsulation of linseed oil with chia mucilage as structuring material: Characterization, stability and enrichment of orange juice. Food Research International, 120, 872-879, 2019.
Cai, J., Xu, W., Liu, Y., Zhu, Z., Liu, G., Ding, W., ... & Luo, Y. Robust construction of flexible bacterial cellulose@ Ni (OH) 2 paper: toward high capacitance and sensitive H2O2 detection. Engineered Science, 5(5), 21-29, 2019.
Kashfipour, M. A., Mehra, N., Dent, R. S., & Zhu, J. Regulating intermolecular chain interaction of biopolymer with natural polyol for flexible, optically transparent and thermally conductive hybrids. Engineered Science, 8(3), 11-18, 2019.
Zhao, S., Sun, Q., Gu, Y., Yang, W., Chen, Y., Lin, J., ... & Guo, Z. Enteromorpha prolifera polysaccharide based coagulant aid for humic acids removal and ultrafiltration membrane fouling control. International journal of biological macromolecules, 152, 576-583, 2020.
Ogaji, I. J., Nep, E. I., & Audu-Peter, J. D. Advances in natural polymers as pharmaceutical excipients, 2012.
Bustamante, M., Oomah, B. D., Rubilar, M., & Shene, C. Effective Lactobacillus plantarum and Bifidobacterium infantis encapsulation with chia seed (Salvia hispanica L.) and flaxseed (Linum usitatissimum L.) mucilage and soluble protein by spray drying. Food Chemistry, 216, 97-105, 2017.
Beyza, A. R. D. A., Zengin, S., & Okutucu, B. The synthesizing of defatted chia-chitosan beads for drug delivery. Eurasian Journal of Biological and Chemical Sciences, 3(1), 26-30, 2020.
Dehghani, S., Noshad, M., Rastegarzadeh, S., Hojjati, M., & Fazlara, A. Electrospun chia seed mucilage/PVA encapsulated with green cardamonmum essential oils: Antioxidant and antibacterial property. International Journal of Biological Macromolecules, 161, 1-9, 2020.
Madaan, R., Bala, R., Zandu, S. K., & Singh, I. Formulation and Characterization of Fast Dissolving Tablets Using Salvia Hispanica (Chia Seed) Mucilage as Superdisintegrant. ACTA Pharmaceutica Sciencia, 58(1), 2020.
Cortés-Camargo, S., Acuña-Avila, P. E., Rodríguez-Huezo, M. E., Román-Guerrero, A., Varela-Guerrero, V., & Pérez-Alonso, C. Effect of chia mucilage addition on oxidation and release kinetics of lemon essential oil microencapsulated using mesquite gum–Chia mucilage mixtures. Food Research International, 116, 1010-1019, 2019.
Rosas‐Ramírez, D. G., Fragoso‐Serrano, M., Escandón‐Rivera, S., Vargas‐Ramírez, A. L., Reyes‐Grajeda, J. P., & Soriano‐García, M. Resistance‐modifying activity in vinblastine‐resistant human breast cancer cells by oligosaccharides obtained from mucilage of chia seeds (Salvia hispanica). Phytotherapy Research, 31(6), 906-914, 2017.
Mohamed, D. A., Mohamed, R. S., & Fouda, K. Anti-inflammatory potential of chia seeds oil and mucilage against adjuvant-induced arthritis in obese and non-obese rats. Journal of basic and clinical physiology and pharmacology, 31(1), 2020.
Tamargo, A., Martin, D., Del Hierro, J. N., Moreno-Arribas, M. V., & Muñoz, L. A. Intake of soluble fibre from chia seed reduces bioaccessibility of lipids, cholesterol and glucose in the dynamic gastrointestinal model simgi®. Food Research International, 137, 109364, 2020.
Menga, V., Amato, M., Phillips, T. D., Angelino, D., Morreale, F., & Fares, C. Gluten-free pasta incorporating chia (Salvia hispanica L.) as thickening agent: An approach to naturally improve the nutritional profile and the in vitro carbohydrate digestibility. Food Chemistry, 221, 1954-1961, 2017.
Antigo, J. L. D., Stafussa, A. P., de Cassia Bergamasco, R., & Madrona, G. S. Chia seed mucilage as a potential encapsulating agent of a natural food dye. Journal of Food Engineering, 285, 110101, 2020b.
Brax, M., Buchmann, C., & Schaumann, G. E. Biohydrogel induced soil–water interactions: how to untangle the gel effect? A review. Journal of Plant Nutrition and Soil Science, 180(2), 121-141, 2017.
Czarnes, S., Hallett, P. D., Bengough, G. B., & Young, I. M. Root‐ and microbial‐derived mucilages affect soil structure and water transport. European Journal of Soil Science, 51, 435– 443, 2000.
Wang, Z. H., Fang, H., & Chen, M. Effects of root exudates of woody species on the soil anti-erodibility in the rhizosphere in a karst region, China. PeerJ, 5, e3029, 2017.
Peng, X. H., Hallett, P. D., Zhang, B., & Horn, R. Physical response of rigid and non‐rigid soils to analogues of biological exudates. European Journal of Soil Science, 62, 676– 684, 2011.
Zhang, B., Peng, X. H., Zhao, Q. G., & Hallett, P. D. Eluviation of dissolved organic carbon under wetting and drying and its influence on water infiltration in degraded soils restored with vegetation. European Journal of Soil Science, 55, 725– 737, 2004.
Di Marsico, A., Scrano, L., Amato, M., Gàmiz, B., Real, M., & Cox, L. Mucilage from seeds of chia (Salvia hispanica L.) used as soil conditioner; effects on the sorption-desorption of four herbicides in three different soils. Science of the Total Environment, 625, 531-538, 2018a.
Di Marsico, A., Scrano, L., Labella, R., Lanzotti, V., Rossi, R., Cox, L., ... & Amato, M. Mucilage from fruits/seeds of chia (Salvia hispanica L.) improves soil aggregate stability. Plant and Soil, 425(1), 57-69, 2018b.

