Imunomodulação com cogumelos: <em>Cordyceps sinensis, Ganoderma lucidum e Grifola frondosa</em>
Immunomodulation with mushrooms: <em>Cordyceps sinensis, Ganoderma lucidum e Grifola frondosa</em>
DOI:
https://doi.org/10.34117/bjdv8n10-086Keywords:
cogumelos medicinais, imunomoduladores, segurançaAbstract
O uso de cogumelos é de grande importância para a economia mundial e muito além da gastronomia, o seu potencial terapêutico é notável. Cordyceps sinensis, Ganoderma lucidum e Grifola frondosa são exemplos de cogumelos que a cada dia estão se tornando mais relevantes para a comunidade científica. Estudos mostram que os cogumelos possuem múltiplas atividades farmacológicas imunomoduladoras, anti-inflamatórias, antioxidantes, antibacterianas, hepatoprotetoras, neuroprotetoras e cardioprotetoras. O trabalho tem por objetivo analisar os possíveis efeitos farmacoterapêuticos antioxidantes, imunomoduladores e toxicológicos dos cogumelos Cordyceps sinensis, Ganoderma lucidum e Grifola frondosa. O presente artigo é constituído de uma pesquisa bibliográfica integrativa, por meio de busca em diferentes bases de dados como PUBMED, Google acadêmico e SciELO. Na pesquisa foram considerados artigos completos, em língua portuguesa, inglesa e espanhola, publicados entre 2010 e 2022, sem considerar o marco temporal de documentos com relevância para o tema. É indispensável a necessidade de verificar os efeitos terapêuticos através de estudos e pesquisas para analisar a efetividade do tratamento, mesmo que as pesquisas atuais tenham se mostrado bastante promissoras e com conhecimentos cada vez mais importantes. Hoje em dia, já existem ensaios para apresentar sua segurança e pesquisas têm se mostrado cada vez mais constantes.
References
ÁLVAREZ, Micaela et al. Development of a Methodology for Estimating the Ergosterol in Meat Product-Borne Toxigenic Moulds to Evaluate Antifungal Agents. Foods, [S.L.], v. 10, n. 2, p. 438-452, 17 fev. 2021. Link
AYEKA, Peter Amwoga. Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: a review. Evidence-Based Complementary and Alternative Medicine, [S.L.], v. 2018, p. 1-9, 2018. Hindawi Limited. Link
BATRA, Priya et al. Probing Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes): a bitter mushroom with amazing health benefits. International Journal of Medicinal Mushrooms, [S.L.], v. 15, n. 2, p. 127-143, fev. 2013. Begell House. Link
BLAGODATSKI, Artem et al. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget, [S.L.], v. 9, n. 49, p. 29259-29274, 26 jun. 2018. Impact Journals, LLC. Link
BLUMBERG, Neil et al. Transfusion medicine: a research agenda for the coming years. Transfusion And Apheresis Science, [S.L.], v. 58, n. 5, p. 698-700, out. 2019. Elsevier BV. Link
BRASIL. Ministério da Saúde. ANVISA – Agência Nacional de Vigilância Sanitária. Resolução - CNNPA nº 12, de 1978. Link
CAMARGO, M. R. et al. Ganoderma lucidum polysaccharides inhibit in vitro tumorigenesis, cancer stem cell properties and epithelial-mesenchymal transition in oral squamous cell carcinoma. Journal of Ethnopharmacology, v. 286, 2022. Link
CHAN, Sze Wa et al. The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharmaceutical Biology, [S.L.], v. 59, n. 1, p. 1159-1169, 1 jan. 2021. Informa UK Limited. Link
CRUVINEL, Wilson de Melo et al. Sistema imunitário: parte I. Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória. Revista Brasileira de Reumatologia, [S.L.], v. 50, n. 4, p. 434-447, ago. 2010. FapUNIFESP (SciELO). Link.
DAI, Rongchen et al. Mycomedicine: a unique class of natural products with potent anti-tumour bioactivities. Molecules, [S.L.], v. 26, n. 4, p. 1113, 19 fev. 2021. MDPI AG. Link
DEEPALAKSHMI, K et al. Therapeutic properties and current medical usage of medicinal mushroom: Ganoderma lucidum. International Journal of Pharmaceutical Sciences and Research, [S.L.], v. 2, n. 8, p. 1922-1929, 1 ago. 2011. Link
DU, Bin et al. Skin Health Promotion Effects of Natural Beta-Glucan Derived from Cereals and Microorganisms: a review. Phytotherapy Research, [S.L.], v. 28, n. 2, p. 159-166, 11 mar. 2013. Wiley. Link
ELDER, Matthew J. et al. β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production. Frontiers In Immunology, [S.L.], v. 8, n. 791, p. 1-9, 7 jul. 2017. Frontiers Media SA. Link
FERREIRA, Isabel C.F.R. et al. Compounds from Wild Mushrooms with Antitumor Potential. Anti-Cancer Agents in Medicinal Chemistry, [S.L.], v. 10, n. 5, p. 424-436, 1 jun. 2010. Bentham Science Publishers Ltd.. Link
FERREIRA, Isabel Cristina Fernandes Rodrigues. Explorando a bioatividade dos cogumelos: propriedades antitumorais, antioxidantes e antimicrobianas. In: VI SIMPÓSIO NACIONAL SOBRE COGUMELOS COMESTÍVEIS., 6., 2013, Manaus. Anais - Proceedings. Manaus, AM: Embrapa, 2013. v. 1, p. 258-261. Link
GHOSH, Rajarshi et al. Panax quinquefolius (North American Ginseng) Polysaccharides as Immunomodulators: current research status and future directions. Molecules, [S.L.], v. 25, n. 24, p. 5854, 11 dez. 2020. MDPI AG. Link
GUGGENHEIM, Alena G. et al. Immune Modulation From Five Major Mushrooms: application to integrative oncology. Integrative Medicine: A Clinician'S Journal, [S.L.], v. 13, n. 1, p. 32-44, fev. 2014. Link
JEITLER, Michael et al. Significance of Medicinal Mushrooms in Integrative Oncology: a narrative review. Frontiers In Pharmacology, [S.L.], v. 11, n. 11, p. 1-15, 11 nov. 2020. Frontiers Media SA. Link
JEONG, Jin-Woo et al. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. International Immunopharmacology, [S.L.], v. 10, n. 12, p. 1580-1586, dez. 2010. Elsevier BV. Link
KATZ, M. J. From Research to Manuscript: A Guide to Scientific Writing. 2ª ed. Berlim: Springer, 2009.
KLAUS, Anita et al. Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa. Food Research International, [S.L.], v. 67, p. 272-283, jan. 2015. Elsevier BV. Link
LABRO, Marie-Thérèse. Immunomodulatory effects of antimicrobial agents. Part I: antibacterial and antiviral agents. Expert Review of Anti-Infective Therapy, [S.L.], v. 10, n. 3, p. 319-340, mar. 2012. Informa UK Limited. Link
LIU, Yi et al. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evidence-Based Complementary and Alternative Medicine, [S.L.], v. 2015, p. 1-12, 2015. Hindawi Limited. Link
MA, Xiao-Lei et al. Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa. Chinese Journal of Natural Medicines, [S.L.], v. 13, n. 12, p. 906-914, dez. 2015. Elsevier BV. Link
MASUDA, Yuki et al. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunology, Immunotherapy, [S.L.], v. 59, n. 10, p. 1531-1541, 20 jun. 2010. Springer Science and Business Media LLC. Link
MASUDA, Yuki et al. Oral administration of soluble β-glucans extracted fromGrifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice. International Journal of Cancer, [S.L.], v. 133, n. 1, p. 108-119, 15 fev. 2013. Wiley. Link
NIE, Shaoping et al. Current development of polysaccharides from Ganoderma: isolation, structure and bioactivities. Bioactive Carbohydrates and Dietary Fibre, [S.L.], v. 1, n. 1, p. 10-20, jan. 2013. Elsevier BV. Link
NIEGO, Allen Grace et al. Macrofungi as a Nutraceutical Source: promising bioactive compounds and market value. Journal Oof Fungi, v. 7, n. 5, p. 397-429, 19 maio de 2021. MDPI AG. Link
OLIVARES, Pedro R. et al. Ganoderma lucidum mejora la condición física en mujeres con fibromialgia. Nutricion Hospitalaria, n. 5, p. 2126-2135, 1 nov. 2015. GRUPO AULA MEDICA. Link
PANDA, Santosh K. et al. Innate Lymphoid Cells in Mucosal Immunity. Frontiers In Immunology, [S.L.], v. 10, n. 861, 7 de Maio de 2019. Frontiers Media SA. Link
PANDYA, Urja et al. Bioactive mushroom polysaccharides as antitumor: an overview. Natural Product Research, [S.L.], v. 33, n. 18, p. 2668-2680, 4 mai. 2018. Informa UK Limited. Link
PAULI, Priscila Abackerli de. AVALIAÇÃO DA COMPOSIÇÃO QUÍMICA, COMPOSTOS BIOATIVOS E ATIVIDADE ANTIOXIDANTE EM COGUMELOS COMESTÍVEIS. 2010. 73 f. Dissertação (Mestrado) - Curso de Biotecnologia, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP, 2010. Disponível em: https://repositorio.unesp.br/bitstream/handle/11449/88636/credendio_pap_me_arafcf.pdf?sequence=1&isAllowed=y. Acesso em: 05 maio 2022 Link
PHILLIPS, Katherine M. et al. Vitamin D and Sterol Composition of 10 Types of Mushrooms from Retail Suppliers in the United States. Journal Of Agricultural and Food Chemistry, [S.L.], v. 59, n. 14, p. 7841-7853, 23 jun. 2011. American Chemical Society (ACS). Link
SEYFRIED, M. et al. Pectinas de plantas medicinais: características estruturais e atividades imunomoduladoras. Revista Brasileira de Plantas Medicinais, [S.L.], v. 18, n. 1, p. 201-214, mar. 2016. FapUNIFESP (SciELO). Link
SHAMSAEI, S. et al. Recent findings on the role of fungal products in the treatment of cancer. Clinical And Translational Oncology, [S.L.], v. 23, n. 2, p. 197-204, 18 jun. 2020. Springer Science and Business Media LLC.
SOHRETOGLU, Didem et al. Ganoderma lucidum Polysaccharides as An Anti-cancer Agent. Anti-Cancer Agents in Medicinal Chemistry, [S.L.], v. 18, n. 5, p. 667-674, 21 ago. 2018. Bentham Science Publishers Ltd.. Link
SUAREZ-ARROYO, Ivette J. et al. Anti-Tumor Effects of Ganoderma lucidum (Reishi) in Inflammatory Breast Cancer in In Vivo and In Vitro Models. Plos One, [S.L.], v. 8, n. 2, p. 57431-57443, 28 fev. 2013. Public Library of Science (PLoS). Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585368/. Acesso em: 05 maio 2022. Link
VENTURELLA, Giuseppe et al. Medicinal Mushrooms: bioactive compounds, use, and clinical trials. International Journal of Molecular Sciences, [S.L.], v. 22, n. 2, p. 634, 10 jan. 2021. MDPI AG. Link
WACHTEL-GALOR, Sissi et al. Ganoderma lucidum (Lingzhi or Reishi): a medicinal mushroom. In: BENZIE, Iris F. F. et al. Herbal Medicine: biomolecular and clinical aspects. 2. ed. Estados Unidos: Taylor and Francis Group, 2011. Cap. 9. p. 113-132. Link
WANG, Li et al. Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review. Rsc Advances, [S.L.], v. 10, n. 69, p. 42084-42097, 2020. Royal Society of Chemistry (RSC). Link
WANG, Mi et al. Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice. Carbohydrate Polymers, [S.L.], v. 89, n. 2, p. 461-466, jun. 2012. Elsevier BV. Link
WASSER, Solomon P.. Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Applied Microbiology and Biotechnology, [S.L.], v. 89, n. 5, p. 1323-1332, 29 dez. 2010. Springer Science and Business Media LLC Link
WEIHERMANN, Viktoria et al. Interferon gama: um gene-chave na defesa contra micobactérias. Genética na Escola., Amazonas, v. 11, n. 2, p. 224-231, dez. 2016. Link
WU, Pengkai et al. Effects of heat on the biological activity of wild Cordyceps sinensis. Journal of Traditional Chinese Medical Sciences, [S.L.], v. 2, n. 1, p. 32-38, jan. 2015. Elsevier BV. Link
WU, Shu-Jing et al. - Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. The American journal of Chinese medicine. 41:1 (2013) (131–44) Link
XIAO, Jian-Hui et al. Nucleosides, a Valuable Chemical Marker for Quality Control in Traditional Chinese Medicine Cordyceps. Recent Patents on Biotechnology, [S.L.], v. 7, n. 2, p. 153-166, 31 jul. 2013. Bentham Science Publishers Ltd.. Link
XU, Jin et al. The Mechanisms of Pharmacological Activities of Ophiocordyceps sinensis Fungi. Phytotherapy Research, [S.L.], v. 30, n. 10, p. 1572-1583, 3 jul. 2016. Wiley. Link
XU, Zengtao et al. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. The American Journal f Chinese Medicine, [S.L.], v. 39, n. 01, p. 15-27, jan. 2011. World Scientific Pub Co Pte L Link
YOUSSEF, Lyla A. et al. Transfusion-related immunomodulation. Current Opinion In Hematology, [S.L.], v. 24, n. 6, p. 551-557, nov. 2017. Ovid Technologies (Wolters Kluwer Health). Link
ZHANG, Jiali et al. Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co. International Immunopharmacology, [S.L.], v. 11, n. 12, p. 2251-2257, dez. 2011. Elsevier BV. Link
ZHAO, Shuang et al. Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products. Journal of Fungi, [S.L.], v. 6, n. 4, p. 269, 8 nov. 2020. MDPI AG. Link
