Prevalência de substâncias psicoativas em pacientes vítimas de trauma atendidas em um hospital geral

Prevalence of psychoactive substances in trauma victims assisted in a general hospital

Authors

  • Fernando Engel Gerbase
  • Maria Eduarda Krützmann
  • Vanessa Becher da Silva
  • Cristiane Pires da Silva
  • Octaviano Pereira Zago Sagrilo
  • Rafael Linden
  • Marina Venzon Antunes

DOI:

https://doi.org/10.34117/bjdv8n9-013

Keywords:

ferimentos e lesões, Etanol, drogas ilícitas, prevenção secundária, transtornos relacionados ao uso de substâncias psicoativas

Abstract

Objetivos: O trauma é a primeira causa de morte na população jovem e estudar seus fatores de risco é importante para o planejamento de medidas de prevenção. Neste sentido, o objetivo do estudo foi estimar a prevalência de substâncias psicoativas em pacientes atendidos no departamento de emergência de um Hospital Geral por qualquer tipo de trauma no período de 6 meses. Métodos: foi realizado um estudo prospectivo de corte transversal no departamento de emergência de um hospital geral. Foi determinada a alcoolemia e realizada análise toxicológica de substâncias psicoativas por cromatografia liquida de alta eficiência associada a espectrometria de massas (LC-MS/MS) em amostras de sangue colhidas até 6 horas após o trauma. Dados sociodemográficos, tipo e severidade do trauma foram registrados.  Resultados: Foram incluídos 238 pacientes, com idade média de 42 anos, majoritariamente do sexo masculino (68%), solteiros (46%) e economicamente ativos (66%). Cerca de 20% dos traumas foi severo, com maior prevalência de colisão de trânsito (64%). Pelo menos uma substância psicoativa foi detectada em 33 % dos pacientes, Álcool em 11,8%, cocaína em 9,2%, cannabis em 7,9%, cetamina em 0,8%, benzodiazepínicos em 4,6%, antidepressivos em 8,2% e múltiplas substâncias em 7,9%. Alcoolemia positiva foi associada significativamente ao sexo masculino e a traumas mais severos. Conclusão: a prevalência de pacientes traumatizados sob efeito de alguma substância psicoativa foi alta em nossa amostra. A identificação desses pacientes no departamento de emergência e intervenções de prevenção secundária são essenciais para diminuir a recorrência do trauma, a morbimortalidade e os custos desta doença.

References

Sakran, J. V., Greer, S. E., Werlin, E., & McCunn, M. (2012). Care of the injured worldwide: trauma still the neglected disease of modern society. Scandinavian journal of trauma, resuscitation and emergency medicine, 20(1), 64.

World Health Organization. (2014). Injuries and violence: the facts.

World Health Organization. (2003). The World health report: 2003: shaping the future.

Reichenheim, M. E., De Souza, E. R., Moraes, C. L., de Mello Jorge, M. H. P., Da Silva, C. M. F. P., & de Souza Minayo, M. C. (2011). Violence and injuries in Brazil: the effect, progress made, and challenges ahead. The Lancet, 377(9781), 1962-1975.

DATASUS. Informações de Saúde: Mortalidade – Rio Grande do Sul. Disponível em <http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sim/cnv/obt10rs.def>. Acesso em: 12 abril 2018

Florence, C., Simon, T., Haegerich, T., Luo, F., & Zhou, C. (2015). Estimated lifetime medical and work-loss costs of fatal injuries—United States, 2013. Morbidity and Mortality Weekly Report, 64(38), 1074-1077.

Florence, C., Haegerich, T., Simon, T., Zhou, C., & Luo, F. (2015). Estimated lifetime medical and work-loss costs of emergency department–treated nonfatal injuries—United States, 2013. Morbidity and Mortality Weekly Report, 64(38), 1078-1082.

Moore, E. E. (2005). Alcohol and trauma: the perfect storm.Journal of Trauma and Acute Care Surgery, 59(3), S53-S56.

Behnood, A., & Mannering, F. L. (2017). The effects of drug and alcohol consumption on driver injury severities in single-vehicle crashes. Traffic injury prevention, 18(5), 456-462.

Cannon, R., Bozeman, M., Miller, K. R., Smith, J. W., Harbrecht, B., Franklin, G., & Benns, M. (2014). The prevalence and impact of prescription controlled substance use among injured patients at a Level I trauma center. Journal of trauma and acute care surgery, 76(1), 172-175.

Braillon, A., & Dubois, G. (2005). Alcohol and public health.The Lancet, 365(9468), 1387.

Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., ... & Burstein, R. (2013). Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. The Lancet, 382(9904), 1575-1586.

Rivara, F. P., Koepsell, T. D., Jurkovich, G. J., Gurney, J. G., & Soderberg, R. (1993). The effects of alcohol abuse on readmission for trauma. Jama, 270(16), 1962-1964.

Mancino, M., Cunningham, M. R., Davidson, P., & Fulton, R. L. (1996). Identification of the motor vehicle accident victim who abuses alcohol: an opportunity to reduce trauma. Journal of studies on alcohol, 57(6), 652-658.

Dischinger, P. C., Mitchell, K. A., Kufera, J. A., Soderstrom, C. A., & Lowenfels, A. B. (2001). A longitudinal study of former trauma center patients: the association between toxicology status and subsequent injury mortality. Journal of Trauma and Acute Care Surgery, 51(5), 877-886.

Caufeild, J., Singhal, A., Moulton, R., Brenneman, F., Redelmeier, D., & Baker, A. J. (2004). Trauma recidivism in a large urban Canadian population. Journal of Trauma and Acute Care Surgery, 57(4), 872-876.

Fabbri, A., Marchesini, G., Dente, M., Iervese, T., Spada, M., & Vandelli, A. (2005). A positive blood alcohol concentration is the main predictor of recurrent motor vehicle crash. Annals of emergency medicine, 46(2), 161-167.

McCoy, A. M., Como, J. J., Greene, G., Laskey, S. L., & Claridge, J. A. (2013). A novel prospective approach to evaluate trauma recidivism: the concept of the past trauma history. Journal of Trauma and Acute Care Surgery, 75(1), 116-121.

Cordovilla-Guardia, S., Fernandez-Mondejar, E., Vilar-Lopez, R., Navas, J. F., Portillo-Santamaria, M., Rico-Martín, S., & Lardelli-Claret, P. (2017). Effect of a brief intervention for alcohol and illicit drug use on trauma recidivism in a cohort of trauma patients. PloS one, 12(8), e0182441.

Gentilello, L. M., Rivara, F. P., Donovan, D. M., Jurkovich, G. J., Daranciang, E., Dunn, C. W., ... & Ries, R. R. (1999). Alcohol interventions in a trauma center as a means of reducing the risk of injury recurrence. Annals of surgery,230(4), 473.

Nunn, J., Erdogan, M., & Green, R. S. (2016). The prevalence of alcohol-related trauma recidivism: a systematic review.Injury, 47(3), 551-558.

Smith, G. S., Branas, C. C., & Miller, T. R. (1999). Fatal nontraffic injuries involving alcohol: a metaanalysis. Annals of emergency medicine, 33(6), 659-668.

MacLeod, J. B., & Hungerford, D. W. (2011). Alcohol-related injury visits: do we know the true prevalence in US trauma centres?. Injury, 42(9), 922-926.

Afshar, M., Netzer, G., Salisbury-Afshar, E., Murthi, S., & Smith, G. S. (2016). Injured patients with very high blood alcohol concentrations. Injury, 47(1), 83-88.

Damsere-Derry, J., Palk, G., & King, M. (2018). Prevalence of alcohol among nonfatally injured road accident casualties in two level III trauma centers in northern Ghana. Traffic injury prevention, 19(2), 118-124.

Egerton‐Warburton, D., Gosbell, A., Moore, K., Wadsworth, A., Richardson, D., & Fatovich, D. M. (2018). Alcohol‐related harm in emergency departments: a prospective, multi‐centre study.Addiction, 113(4), 623-632.

Guardia, S. C., Rodríguez-Bolaños, S., López, F. G., Lara-Rosales, R., Sánchez, F. P., Rayo, A., & Fernández-Mondéjar, E. (2013). Alcohol and/or drug abuse favors trauma recurrence and reduces the trauma-free period. Medicina Intensiva (English Edition), 37(1), 6-11.

Cordovilla-Guardia, S., Guerrero-López, F., Maldonado, A., Vilar-López, R., Salmerón, J. M., Romero, I., ... & Fernández-Modéjar, E. (2014). Trauma risk perception related to alcohol, cannabis, and cocaine intake. European journal of trauma and emergency surgery, 40(6), 693-699.

Relja, B., Menke, J., Wagner, N., Auner, B., Voth, M., Nau, C., & Marzi, I. (2016). Effects of positive blood alcohol concentration on outcome and systemic interleukin-6 in major trauma patients. Injury, 47(3), 640-645.

Rood, P. P., Haagsma, J. A., M Boersma, S., Tancica, A., Van Lieshout, E. M., Mulligan, T., ... & Patka, P. (2016). Psychoactive substance (drugs and alcohol) use by Emergency Department patients before injury. European Journal of Emergency Medicine, 23(2), 147-154.

Legrand, S. A., Isalberti, C., der Linden, T. V., Bernhoft, I. M., Hels, T., Simonsen, K. W., ... & Pauliukevicius, A. (2013). Alcohol and drugs in seriously injured drivers in six European countries. Drug testing and analysis, 5(3), 156-165.

Freitas, E. A. M. D., Mendes, I. D., & Oliveira, L. C. M. D. (2008). Ingestão alcoólica em vítimas de causas externas atendidas em um hospital geral universitário. Revista de Saúde Pública, 42, 813-821.

Cornwell III, E. E., Belzberg, H., Velmahos, G., & Chan, L. S. (1998). The prevalence and effect of alcohol and drug abuse on cohort-matched critically injured patients. The American Surgeon, 64(5), 461.

Carrigan, T. D., Field, H., Illingworth, R. N., Gaffney, P., & Hamer, D. W. (2000). Toxicological screening in trauma.Emergency Medicine Journal, 17(1), 33-37.

Cordovilla-Guardia, S., Lardelli-Claret, P., Vilar-López, R., López-Espuela, F., Guerrero-López, F., & Fernández-Mondéjar, E. (2019). The effect of central nervous system depressant, stimulant and hallucinogenic drugs on injury severity in patients admitted for trauma. Gaceta sanitaria, 33, 4-9.

Gazal-Carvalho, C., Carlini-Cotrim, B., Silva, O. A., & Sauaia, N. (2002). Blood alcohol content prevalence among trauma patients seen at a level 1 trauma center. Revista de saude publica, 36(1), 47-54.

Baker, S. P., o'Neill, B., Haddon Jr, W., & Long, W. B. (1974). The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. Journal of Trauma and Acute Care Surgery, 14(3), 187-196.

Beverland, D. E., & Rutherford, W. H. (1983). An assessment of the validity of the injury severity score when applied to gunshot wounds. Injury, 15(1), 19-22.

Reis, A. D., Figlie, N. B., & Laranjeira, R. (2006). Prevalence of substance use among trauma patients treated in a Brazilian emergency room. Brazilian Journal of Psychiatry, 28(3), 191-195.

Pandit, V., Patel, N., Rhee, P., Kulvatunyou, N., Aziz, H., Green, D. J., ... & Friese, R. S. (2014). Effect of alcohol in traumatic brain injury: is it really protective?. journal of surgical research, 190(2), 634-639.

Lin, H. L., Lin, T. Y., Soo, K. M., Chen, C. W., Kuo, L. C., Lin, Y. K., ... & Lin, C. L. (2014). The effect of alcohol intoxication on mortality of blunt head injury. BioMed research international,2014.

de Carvalho, H. B., Andreuccetti, G., Rezende, M. R., Bernini, C., Silva, J. S., Leyton, V., & Greve, J. M. D. A. (2016). Alcohol and drug involvement in motorcycle driver injuries in the city of Sao Paulo, Brazil: Analysis of crash culpability and other associated factors. Drug and alcohol dependence, 162, 199-205.

Quessada, A. M., da Silva, A. M. M., Drumond, K. O., de Sousa, J. M., Rodrigues, M. C., & de Souza Almendra, S. R. (2015). Comercialização de Cetamina em Estabelecimentos Veterinários em Teresina-PI. Journal of Health Sciences, 11(1).

Morgan, C. J., Curran, H. V., & Independent Scientific Committee on Drugs (ISCD). (2012). Ketamine use: a review.Addiction, 107(1), 27-38.

Longo, M. C., Hunter, C. E., Lokan, R. J., White, J. M., & White, M. A. (2000). The prevalence of alcohol, cannabinoids, benzodiazepines and stimulants amongst injured drivers and their role in driver culpability: part ii: the relationship between drug prevalence and drug concentration, and driver culpability.Accident Analysis & Prevention, 32(5), 623-632.

Longo, M. C., Hunter, C. E., Lokan, R. J., White, J. M., & White, M. A. (2000). The prevalence of alcohol, cannabinoids, benzodiazepines and stimulants amongst injured drivers and their role in driver culpability: part ii: the relationship between drug prevalence and drug concentration, and driver culpability.Accident Analysis & Prevention, 32(5), 623-632.

Hetland, A., & Carr, D. B. (2014). Medications and impaired driving. Annals of pharmacotherapy, 48(4), 494-506.

Smink, B. E., Egberts, A. C., Lusthof, K. J., Uges, D. R., & De Gier, J. J. (2010). The relationship between benzodiazepine use and traffic accidents. CNS drugs, 24(8), 639-653.

Kelly, E., Darke, S., & Ross, J. (2004). A review of drug use and driving: epidemiology, impairment, risk factors and risk perceptions. Drug and alcohol review, 23(3), 319-344.

Cherpitel, C. J., Ye, Y., Andreuccetti, G., Stockwell, T., Vallance, K., Chow, C., & Brubacher, J. R. (2017). Risk of injury from alcohol, marijuana and other drug use among emergency department patients. Drug and alcohol dependence, 174, 121-127.

Vitale, S. G., Van de Mheen, H., Van de Wiel, A., & Garretsen, H. F. L. (2006). Substance use among emergency room patients: Is self-report preferable to biochemical markers?.Addictive Behaviors, 31(9), 1661-1669.

Kip, M. J., Spies, C. D., Neumann, T., Nachbar, Y., Alling, C., Aradottir, S., ... & Wurst, F. M. (2008). The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting.Alcoholism: Clinical and Experimental Research, 32(7), 1284-1291.

Ramchand, R., Marshall, G. N., Schell, T. L., Jaycox, L. H., Hambarsoomians, K., Shetty, V., ... & Belzberg, H. (2009). Alcohol abuse and illegal drug use among Los Angeles County trauma patients: prevalence and evaluation of single item screener. The Journal of trauma, 66(5), 1461.

Bordin, D., Monedeiro, F. F. S. S., Campos, E., Alves, M., Bueno, L., & Martinis, B. (2015). Técnicas de preparo de amostras biológicas com interesse forense. Sci Chromatogr,7(2), 125-43.

Cordovilla-Guardia, S., Vilar-Lopez, R., Lardelli-Claret, P., Navas, J. F., Guerrero-López, F., & Fernández-Mondéjar, E. (2017). Admission to Intensive Care for a trauma related to alcohol or drugs, a ‘teachable moment’for the beginning of a change. Enfermería Intensiva (English ed.), 28(1), 4-12.

Stewart, R. M., Myers, J. G., Dent, D. L., Ermis, P., Gray, G. A., Villarreal, R., ... & Root, H. D. (2003). Seven hundred fifty-three consecutive deaths in a level I trauma center: the argument for injury prevention. Journal of Trauma and Acute Care Surgery, 54(1), 66-71.

Fleming, M. F., Mundt, M. P., French, M. T., Manwell, L. B., Stauffacher, E. A., & Barry, K. L. (2002). Brief physician advice for problem drinkers: long‐term efficacy and benefit‐cost analysis. Alcoholism: Clinical and experimental research,26(1), 36-43.

Zarkin, G. A., Bray, J. W., Davis, K. L., Babor, T. F., & Higgins-Biddle, J. C. (2003). The costs of screening and brief intervention for risky alcohol use. Journal of Studies on Alcohol, 64(6), 849-857.

Published

2022-09-01

How to Cite

Gerbase, F. E., Krützmann, M. E., Silva, V. B. da, Silva, C. P. da, Sagrilo, O. P. Z., Linden, R., & Antunes, M. V. (2022). Prevalência de substâncias psicoativas em pacientes vítimas de trauma atendidas em um hospital geral: Prevalence of psychoactive substances in trauma victims assisted in a general hospital. Brazilian Journal of Development, 8(9), 60534–60553. https://doi.org/10.34117/bjdv8n9-013

Issue

Section

Original Papers