Sistema linfático do cérebro, nova descoberta? uma revisão bibliográfica / Lymphatic system of the brain, new discovery? a bibliographic review

Authors

  • Iuri Pereira dos Santos
  • José Miguel Aiquel Bellolio
  • José Ignacio Aiquel Bellolio
  • José Luis Aiquel Bellolio
  • José Antonio Aiquel Bellolio
  • Larissa Fernanda de Souza
  • Pablo Clovis Serafim santos Servino
  • Douglas Michael Girardi
  • José Antonio Aiquel Bellolio

DOI:

https://doi.org/10.34117/bjdv8n3-417

Keywords:

sistema linfático, linfonodos, cérebro, drenagem.

Abstract

A revisão bibliográfica do presente estudo tem como objetivo trazer informações atualizadas sobre o sistema linfático cerebral, condensado em um artigo revisional de fácil entendimento para o meio acadêmico e profissional. Através da análise de artigos dos últimos 30 anos, descrevendo de forma abrangente um breve histórico do sistema linfático assim como a anatomia do mesmo, caminhando para uma descrição mais detalhada do sistema linfático cerebral.

References

THOMAS, Jean-Léon; JACOB, Laurent; BOISSERAND, Ligia. Système lymphatique et cerveau. Médecine/Sciences, [S.L.], v. 35, n. 1, p. 55-61, jan. 2019. EDP Sciences. http://dx.doi.org/10.1051/medsci/2018309. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30672459/. Acesso em: 13 set. 2021.

Marconi MA, Lakatos EM. Fundamentos de Metodologia Científica. São Paulo – SP, 8ª ed. Atlas, pg200,2019

BRESLIN, Jerome W.; YANG, Ying; SCALLAN, Joshua P.; SWEAT, Richard S.; ADDERLEY, Shaquria P.; MURFEE, Walter L.. Lymphatic Vessel Network Structure and Physiology. Comprehensive Physiology, [S.L.], p. 207-299, 13 dez. 2018. Wiley. http://dx.doi.org/10.1002/cphy.c180015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30549020/. Acesso em: 30 ago. 2021.

NATALE, Gianfranco; BOCCI, Guido; RIBATTI, Domenico. Scholars and scientists in the history of the lymphatic system. Journal Of Anatomy, [S.L.], v. 231, n. 3, p. 417-429, 14 jun. 2017. Wiley. http://dx.doi.org/10.1111/joa.12644. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28614587/. Acesso em: 21 ago. 2021.

LOUKAS, Marios; BELLARY, Sharath S.; KUKLINSKI, Michael; FERRAUIOLA, Julie; YADAV, Abha; SHOJA, Mohammadali M.; SHAFFER, Kitt; TUBBS, R. Shane. The lymphatic system: a historical perspective. Clinical Anatomy, [S.L.], v. 24, n. 7, p. 807-816, 4 maio 2011. Wiley. http://dx.doi.org/10.1002/ca.21194. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21544873/. Acesso em: 20 ago. 2021.

SUY, Raphael; THOMIS, Sarah; FOURNEAU, Inge. The discovery of lymphatic system in the seventeenth century. Part I: the early history. Acta Chirurgica Belgica, [S.L.], v. 116, n. 4, p. 260-266, 2 jun. 2016. Informa UK Limited. http://dx.doi.org/10.1080/00015458.2016.1176792. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27426661/. Acesso em: 23 ago. 2021.

NETTER, Frank H.. Atlas de anatomia humana. 7ª ed. RIO DE JANEIRO: Elsevier, 2019.

Null M, Agarwal M. Anatomy, Lymphatic System. [Atualizado em 10 de fevereiro de 2021]. In: StatPearls [Internet]. Treasure Island (FL):

StatPearls Publishing; 2021 Jan-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK513247/

OLSZEWSKI, Waldemar L. The Lymphatic System in Body Homeostasis: physiological conditions. Lymphatic Research And Biology, [S.L.], v. 1, n. 1, p. 11-24, jan. 2003. Mary Ann Liebert Inc. http://dx.doi.org/10.1089/15396850360495655. Disponível em: https://pubmed.ncbi.nlm.nih.gov/15624317/. Acesso em: 20 ago. 2021.

Ozdowski L, Gupta V. Fisiologia, Sistema Linfático. [Atualizado em 9 de maio de 2021]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK557833/

SUN, Bao-Liang; WANG, Li-Hua; YANG, Tuo; SUN, Jing-Yi; MAO, Lei-Lei; YANG, Ming-Feng; YUAN, Hui; COLVIN, Robert A.; YANG, Xiao-Yi. Lymphatic drainage system of the brain: a novel target for intervention of neurological diseases. Progress In Neurobiology, [S.L.], v. 163-164, p. 118-143, abr. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.pneurobio.2017.08.007. Disponível em: https://www.sciencedirect.com/science/article/pii/S030100821730062X. Acesso em: 03 set. 2021.

TORIELLO, María; GONZÁLEZ-QUINTANILLA, Vicente; PASCUAL, Julio. El sistema glinfático y su implicación en las enfermedades del sistema nervioso. Medicina Clínica, [S.L.], v. 156, n. 7, p. 339-343, abr. 2021. Elsevier BV. http://dx.doi.org/10.1016/j.medcli.2020.08.020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33423825/. Acesso em: 09 out. 2021.

Mikhael M, Khan YS. Anatomia, Abdômen e Pelve, Drenagem Linfática. [Atualizado em 31 de julho de 2021]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK557720/

MOORE, K. L.; DALEY II, A. F. Anatomia orientada para a clínica. 7ª.edição. Guanabara Koogan. Rio de Janeiro, 2014.

VAZ, Marcelo Alexandre Costa; FERNANDES, Paulo Pêgo. Quilotórax. Jornal Brasileiro de Pneumologia, [S.L.], v. 32, n. 4, p. 197-203, 1 ago. 2006. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/s1806-37132006000900006. Disponível em: https://www.scielo.br/j/jbpneu/a/RvVbTwp6WrKdxpLkXc5JcHf/?lang=pt. Acesso em: 01 set. 2021.

Bujoreanu I, Gupta V. Anatomy, Lymph Nodes. [Atualizado em 31 de julho de 2021]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK557717/

TAMURA, Ryota; YOSHIDA, Kazunari; TODA, Masahiro. Current understanding of lymphatic vessels in the central nervous system. Neurosurgical Review, [S.L.], v. 43, n. 4, p. 1055-1064, 18 jun. 2019. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/s10143-019-01133-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31209659/. Acesso em: 08 out. 2021.

HE, Wenbo; JING, You; WAN, Qianfen; XIAO, Ke; CHEN, Kening; LU, Yuan; LI, Liang; TANG, Yajie; DENG, Yunte; YAO, Zhaohui. The anatomy and metabolome of the lymphatic system in the brain in health and disease. Brain Pathology, [S.L.], v. 30, n. 2, p. 392-404, 5 dez. 2019. Wiley. http://dx.doi.org/10.1111/bpa.12805. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31747475/. Acesso em: 09 out. 2021.

MESQUITA, Sandro da; FU, Zhongxiao; KIPNIS, Jonathan. The Meningeal Lymphatic System: a new player in neurophysiology. Neuron, [S.L.], v. 100, n. 2, p. 375-388, out. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.neuron.2018.09.022. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30359603/. Acesso em: 13 set. 2021.

BUCCHIERI, Fabio; FARINA, Felicia; ZUMMO, Giovanni; CAPPELLO, Francesco. Lymphatic vessels of the dura mater: a new discovery?. Journal Of Anatomy, [S.L.], v. 227, n. 5, p. 702-703, 18 set. 2015. Wiley. http://dx.doi.org/10.1111/joa.12381. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609205/. Acesso em: 13 set. 2021.

RENNELS, Marshall L.; GREGORY, Thomas F.; BLAUMANIS, Otis R.; FUJIMOTO, Katsukuni; GRADY, Patricia A.. Evidence for a ‘Paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Research, [S.L.], v. 326, n. 1, p. 47-63, fev. 1985. Elsevier BV. http://dx.doi.org/10.1016/0006-8993(85)91383-6. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/0006899385913836. Acesso em: 09 set. 2021.

KIDA, S.; WELLER, R. O.; ZHANG, E-T.; PHILLIPS, M. J.; IANNOTTI, F.. Anatomical pathways for lymphatic drainage of the brain and their pathological significance. Neuropathology And Applied Neurobiology, [S.L.], v. 21, n. 3, p. 181-184, jun. 1995. Wiley. http://dx.doi.org/10.1111/j.1365-2990.1995.tb01048.x. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2990.1995.tb01048.x. Acesso em: 10 set. 2021.

LI, Jicheng; ZHOU, Jilin; SHI, Yuanhe. Scanning electron microscopy of human cerebral meningeal stomata. Annals Of Anatomy - Anatomischer Anzeiger, [S.L.], v. 178, n. 3, p. 259-261, jun. 1996. Elsevier BV. http://dx.doi.org/10.1016/s0940-9602(96)80059-8. Disponível em: https://pubmed.ncbi.nlm.nih.gov/8712374/. Acesso em: 13 set. 2021.

ILIFF, J. J.; WANG, M.; LIAO, Y.; PLOGG, B. A.; PENG, W.; GUNDERSEN, G. A.; BENVENISTE, H.; VATES, G. E.; DEANE, R.; GOLDMAN, S. A.. A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid . Science Translational Medicine, [S.L.], v. 4, n. 147, p. 111-147, 15 ago. 2012. American Association for the Advancement of Science (AAAS). http://dx.doi.org/10.1126/scitranslmed.3003748. Disponível em: https://www.science.org/doi/10.1126/scitranslmed.3003748. Acesso em: 03 set. 2021.

LAMAN, Jon D.; WELLER, Roy O.. Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes. Journal Of Neuroimmune Pharmacology, [S.L.], v. 8, n. 4, p. 840-856, 22 maio 2013. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/s11481-013-9470-8. Disponível em: https://link.springer.com/article/10.1007%2Fs11481-013-9470-8#citeas. Acesso em: 09 set. 2021.

LOUVEAU, Antoine; SMIRNOV, Igor; KEYES, Timothy J.; ECCLES, Jacob D.; ROUHANI, Sherin J.; PESKE, J. David; DERECKI, Noel C.; CASTLE, David; MANDELL, James W.; LEE, Kevin S.. Structural and functional features of central nervous system lymphatic vessels. Nature, [S.L.], v. 523, n. 7560, p. 337-341, 1 jun. 2015. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/nature14432. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26030524/. Acesso em: 06 set. 2021.

ANTILA, Salli; KARAMAN, Sinem; NURMI, Harri; AIRAVAARA, Mikko; VOUTILAINEN, Merja H.; MATHIVET, Thomas; CHILOV, Dmitri; LI, Zhilin; KOPPINEN, Tapani; PARK, Jun-Hee. Development and plasticity of meningeal lymphatic vessels. Journal Of Experimental Medicine, [S.L.], v. 214, n. 12, p. 3645-3667, 15 nov. 2017. Rockefeller University Press. http://dx.doi.org/10.1084/jem.20170391. Disponível em: https://rupress.org/jem/article/214/12/3645/42289/Development-and-plasticity-of-meningeal-lymphatic. Acesso em: 15 set. 2021.

YANKOVA, Galina; BOGOMYAKOVA, Olga; TULUPOV, Andrey. The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance. Reviews In The Neurosciences, [S.L.], 22 fev. 2021. Walter de Gruyter GmbH. http://dx.doi.org/10.1515/revneuro-2020-0106. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33618444/. Acesso em: 15 set. 2021.

LOUVEAU, Antoine; PLOG, Benjamin A.; ANTILA, Salli; ALITALO, Kari; NEDERGAARD, Maiken; KIPNIS, Jonathan. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. Journal Of Clinical Investigation, [S.L.], v. 127, n. 9, p. 3210-3219, 1 set. 2017. American Society for Clinical Investigation. http://dx.doi.org/10.1172/jci90603. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28862640/. Acesso em: 08 out. 2021.

BENVENISTE, Helene; LIU, Xiaodan; KOUNDAL, Sunil; SANGGAARD, Simon; LEE, Hedok; WARDLAW, Joanna. The Glymphatic System and Waste Clearance with Brain Aging: a review. Gerontology, [S.L.], v. 65, n. 2, p. 106-119, 11 jul. 2018. S. Karger AG. http://dx.doi.org/10.1159/000490349. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29996134/. Acesso em: 09 out. 2021.

HABLITZ, Lauren M.; PLÁ, Virginia; GIANNETTO, Michael; VINITSKY, Hanna S.; STÆGER, Frederik Filip; METCALFE, Tanner; NGUYEN, Rebecca; BENRAIS, Abdellatif; NEDERGAARD, Maiken. Circadian control of brain glymphatic and lymphatic fluid flow. Nature Communications, [S.L.], v. 11, n. 1, p. 1-10, 2 set. 2020. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/s41467-020-18115-2. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32879313/. Acesso em: 08 out. 2021.

MESTRE, Humberto; MORI, Yuki; NEDERGAARD, Maiken. The Brain’s Glymphatic System: current controversies. Trends In Neurosciences, [S.L.], v. 43, n. 7, p. 458-466, jul. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.tins.2020.04.003. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32423764/. Acesso em: 08 out. 2021.

JIANG, Quan. MRI and glymphatic system. Stroke And Vascular Neurology, [S.L.], v. 4, n. 2, p. 75-77, 5 abr. 2019. BMJ. http://dx.doi.org/10.1136/svn-2018-000197. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31338214/. Acesso em: 09 out. 2021.

RASMUSSEN, Martin Kaag; MESTRE, Humberto; NEDERGAARD, Maiken. The glymphatic pathway in neurological disorders. The Lancet Neurology, [S.L.], v. 17, n. 11, p. 1016-1024, nov. 2018. Elsevier BV. http://dx.doi.org/10.1016/s1474-4422(18)30318-1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30353860/. Acesso em: 08 out. 2021.

LUNDGAARD, Iben; WANG, Wei; EBERHARDT, Allison; VINITSKY, Hanna Sophia; REEVES, Benjamin Cameron; PENG, Sisi; LOU, Nanhong; HUSSAIN, Rashad; NEDERGAARD, Maiken. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Scientific Reports, [S.L.], v. 8, n. 1, p. 1-10, 2 fev. 2018. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/s41598-018-20424-y. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29396480/. Acesso em: 09 out. 2021.

ILIFF, Jeffrey J.; NEDERGAARD, Maiken. Is There a Cerebral Lymphatic System? Stroke, [S.L.], v. 44, n. 61, jun. 2013. Ovid Technologies (Wolters Kluwer Health). http://dx.doi.org/10.1161/strokeaha.112.678698. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23709744/. Acesso em: 03 set. 2021.

ASPELUND, Aleksanteri; ANTILA, Salli; PROULX, Steven T.; KARLSEN, Tine Veronica; KARAMAN, Sinem; DETMAR, Michael; WIIG, Helge; ALITALO, Kari. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. Journal Of Experimental Medicine, [S.L.], v. 212, n. 7, p. 991-999, 15 jun. 2015. Rockefeller University Press. http://dx.doi.org/10.1084/jem.20142290. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26077718/. Acesso em: 13 set. 2021.

Published

2022-03-30

How to Cite

dos Santos, I. P., Bellolio, J. M. A., Bellolio, J. I. A., Bellolio, J. L. A., Bellolio, J. A. A., de Souza, L. F., Servino, P. C. S. santos, Girardi, D. M., & Bellolio, J. A. A. (2022). Sistema linfático do cérebro, nova descoberta? uma revisão bibliográfica / Lymphatic system of the brain, new discovery? a bibliographic review. Brazilian Journal of Development, 8(3), 22077–22093. https://doi.org/10.34117/bjdv8n3-417

Issue

Section

Original Papers