Síntese e caracterização de complexos de Pd(II) e ligantes nitrogenados com potencial atividade biológica / Synthesis and characterization of Pd(II) complexes and nitrogen ligands with potential biological activity
DOI:
https://doi.org/10.34117/bjdv8n3-013Keywords:
Pd(II), 2, 2'-bis(4, 5-dimetilimidazol), ensaios biológicos.Abstract
Os imidazóis representam uma alternativa interessante no design de compostos biologicamente ativos, pois muitos deles ocorrem naturalmente em sistemas biológicos. Há também um número significativo de imidazóis sintéticos que desempenham papéis importantes no combate à agentes patogênicos. Diversos autores têm obtido sucesso na síntese, caracterização e formação de complexos com destacada atividade biológica envolvendo diiminas (phen, bpy) – cujo interesse está na obtenção de espécies químicas planares, aptas a interagirem com o DNA via intercalação, e ligantes biimidazólicos. Descrevemos nesse trabalho a síntese e caracterização dos complexos diimínicos [Pd(bpy)L]Cl2 (1) e Pd(phen)L]Cl2 (2), sendo L = 2,2’-bis(4,5-dimetilimidazol), bpy = 2,2´-bipiridil, phen = 1,10-fenantrolina. Os complexos foram sintetizados a partir de Na2[PdCl4], seguida da adição de quantidades equimolares de L no mínimo de metanol, sob agitação magnética, seguido da adição de bpy/phen em clorofórmio, dando origem a soluções vermelhas, com bons rendimentos. As análises por espectroscopia na região do infravermelho, ressonância magnética nuclear e análise elementar indicam a formação dos complexos Pd(bpy)L]Cl2 (1) e Pd(phen)L]Cl2 (2). Ensaios leishmanicidas iniciais frente à forma promastigota de L. amazonensis indicaram que o complexo 2 possui atividade biológica, ainda que inferior ao fármaco padrão.
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