Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo
DOI:
https://doi.org/10.34117/bjdv7n12-328Keywords:
Eurytrema coelomaticum, E. pancreaticum, Oxidative stress, Lipid, Diabetes MellitusAbstract
Eurytrematosis is a helminthic disease caused by trematodes belonging to the genus Eurytrema spp. that parasitize the pancreas of many animals and humans. This parasitosis causes chronic fibrosing pancreatitis, fat infiltration in the pancreatic parenchyma, besides damaging the exocrine pancreas, which is similar to that found in patients with Diabetes Mellitus type 1 (DM1). The current work aimed to evaluate the use of bovine pancreas infected with E. coelomaticum as a model to study DM1 pathophysiology. It was carried out macroscopic analyses, parasite identification, total pancreatic lipid determination and oxidative damage biomarkers levels of pancreas naturally infected with E. coelomaticum. Macroscopically, we observed that the infected pancreas had duct obstruction, organ stiffness due to the visible presence of fibrosis, increased adipose tissue deposition, increased protein and lipid damage, as well as increased antioxidant biomarkers (GSH, CAT and VIT C). Thus, it is possible to show that DM1 may have pancreatic parasitism as a possible primary origin. However, more studies are needed to better investigate this possible primary origin; the results obtained here suggest that the use of pancreas parasitized by E. coelomaticum could be a model to investigate DM1 pathophysiology.
References
Aebi H. Catalase in vitro. Methods in Enzymology, 1984.v. 105, p. 121-126. doi: 10.1016/s0076-6879(84)05016-3.
Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet. 2001. 358:221-9. doi: 10.1016/S0140-6736(01)05415-0.
Azevedo JR De, Mannigel RC, Agulhon AZ, Thiago R, Barbiéri AW, Oliveira DCL De, Headley SA. Prevalence and geographical distribution of bovine prevalence eurytrematosis in cattle slaughtered in northern Paraná, Brazil. Pesqui. Vet. Bras. 2004.; 24: 23–26. doi.org/10.1590/S0100-736X2004000100006.
Bassani CA, Sangioni LA, Saut JPE, Headley AS, Yamamura MH. Euritrematose bovina/Bovine eurytrematosis. Semina: Ciências Agrárias, Londrina, 2007. v. 28, n.2, p. 299–316.
Bassani CA, Sangioni LA, Saut JPE, Yamamura MH, Headley SA. Epidemiology of eurytrematosis (Eurytrema spp. Trematoda: Dicrocoeliidae) in slaughtered beef cattle from the central-west region of the state of Paraná, Brazil. Vet. Parasitol. 2006. 141: 356–361. DOI: 10.1016/j.vetpar.2006.06.003
Belém PAD, Alves L R V, Santana ML. Associação entre parasitismo por Eurytrema sp. e glicemia, em bovinos. Rev Vet Zoot, 1997. v.9, p.49-54.
Belém PAD, Oliveira MR, Padovani CR. Alterações pancreáticas em bovinos naturalmente infectados por Eurytrema spp. e sua associação com a carga parasitária e o número de ovos por grama de fezes (OPG). Brazilian Journal of Veterinary Research and Animal Science, 1994., v.31, n.3-4, p.273-281. DOI: https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52077
Belém PAD, Silva JCP, Vieira D. Diabete mellitus em bovino. In: ENCONTRO DE PESQUISAS VETERINÁRIAS, 11, 1986, Jaboticabal, SP. Resumos: Faculdade de Ciências Agrárias e Veterinárias, 1986. UNESP, p.62.
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Canadian Journal of Biochemistry a Physiology, 1959., v.37, n.8, p.911-917. doi: 10.1139/o59-099.
Boyne AF, Ellman GL. A methodology for analysis of tissue sulfhydryl components. Anal. Biochem., 1972. v. 46, p. 639. doi: 10.1016/0003-2697(72)90335-1.
Brum GF, Rosa HZ, Rossato DR, Rosa JLO, Metz VG, Milanesi LH, Burger ME. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotox Res. 2020. https://doi.org/10.1007/s12640-020-00215-y
Brussels, Belgium: International Diabetes Federation (IDF). Disponível em: < https://www.diabetesatlas.org/en/sections/demographic-and-geographic-outline.html>. Acesso em: 15 Maio 2021.
Capen CC. Endocrine System. M.D. Mcgavin, W.W. Carlton, Z.F. Zachary (Eds.), Thomson's Special Veterinary Pathology (third ed.), Mosby, St. Louis (2001), pp. 279-323
Chen DL, Yang KY. Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR-106b Expression and Up-Regulating SIRT1. Journal of Cellular Biochemistry. 2017. Kaifeng, p. 1-8. doi: 10.1002/jcb.26089.
Codo V. Teste cutâneo para diagnóstico da Euritrematose em bovinos. Revista Ceres, Viçosa. 1952. v.9, n.50, p.132-138.
Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TWH, Atkinson MA, Roep BO, Herrath MG. Demonstration of islet autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. Journal of Experimental Medicine, New York, 2012., v. 209, n. 1, p. 51-60, jan. https://doi.org/10.1084/jem.20111187.
Correa WM. Eutryema pancreaticum: clínica e diagnóstico em bovinos. Hora Veterinária, 1984..V.4, n. 19, p. 31 – 34.
Dantas JR, Almeida MH, Barone B, Campos F, Kupfer R, Milech A, Zajdenverg L, Rodacki M, Oliveira JEP. Avaliação da função pancreática em pacientes com diabetes melito tipo 1 de acordo com a duração da doença. Arq Bras Endocrinol Metab. 2009., V.53. https://doi.org/10.1590/S0004-27302009000100010
Dordevic M, Mihailović M, Arambašić JJ, Grdović N, Uskoković A, Tolić A, Sinadinović M, Rajić J, Mišić D, Šiler B, Poznanović G, Vidaković M, Dinić S. Centaurium erythraea methanol extract protects red blood cells from oxidative damage in streptozotocin-induced diabetic rats. Journal Of Ethnopharmacology. Belgrado, 2017., p. 1-34. 12. Disponível em: http://scihub.io/http://dx.doi.org/10.1016/j.jep.2017.03.016.
Eleazu C, Ezekwibe I, Egbe M, Saidu S, Eleazu K, Egedigwe C. Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocini induced diabetic rats: effect on the oral glucose tolerance of normoglycemic rats. Acta Sci. Pol. Technol. Aliment. Abakalik, 2017., p. 1-9. 13. DOI: 10.17306/J.AFS.2017.0460.
Elgawish A, Glomb M, Friedlander M, Monnier VM. Involvement of hydrogen peroxide in collagen cross-linking by high glucose in vitro and in vivo. The Journal of Biological Chemistry. 1996. 271 (22): 12964-12971. doi: 10.1074/jbc.271.22.12964.
Feldman EC, Nelson RW. Diabetes Mellitus In: Canine and feline endocrinology and reproduction. Philadelphia: Saunders, 2003. 3 ed., p. 339-391.
Fernandez MA, Thiengo SC, Paraense WL. Primeiro registro de Plesiophysa Plesiophysa guadeloupensis guadeloupensis (“Fischer” ischer” Mazé) no Estado do Rio de Janeiro. Revista Brasileira de Zoologia, 2006. v. 23, n. 3, pg 883–885.
Frey BN, Valvassori SS, Gomes KM, Martins MR, Dal-Pizzol F, Kapczinski F, Quevedo J. Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure. Brain Res., 2006. v.1097, p. 224-229. doi: 10.1016/j.brainres.2006.04.076.
Galley H, Davies MJ, Webster NR. Ascorbil radical formation in patients with sepsis: effects of ascorbate loading. Free Radical Biology & Medicine, 1996. v. 20, p. 139-143. doi: 10.1016/0891-5849(95)02022-5.
Gepts W, Lecompte PM. The pancreatic islet in diabetes. American Journal of Medicine, 1981. v.70, n.1, p.105-113. https://doi.org/10.1016/0002-9343(81)90417-4.
Gite SS, Yadav SA, Nilegaonkar SS, Agte VV. Functional food supplements to ameliorate the secondary complications in high fructose fed diabetic rats. Food and Function. Pune, 2017., p. 1-10. https://doi.org/10.1039/C7FO00283A.
Graydon RJ, Carmichael IH, Sanches MD, Weidosari E, Widjayanti S. Mortalities and wasting in Indonesian sheep associated with the trematoda Eurytrema pancreaticum. Veterinary Record, 1992. London, v.131, n.19, p.443. doi: 10.1136/vr.131.19.443-a.
Grist A. Bovine Meat Inspection. 2nd ed. Nottingham University Press, 2008. Nottingham. 278p.
Grosskopf HM, Schwertz CI, Machado G, Bottari NB, Silva ES Da; Gabriel ME, Lucca NJ, Alves MS, Schetinger MRC, Morsch VM, Mendes RE, Silva AS Da. Cattle naturally infected by Eurytrema coelomaticum: Relation between adenosine deaminase activity and zinc levels. Res. Vet. Sci. 2016. 110: 79-84. doi: 10.1016/j.rvsc.2016.10.016.
Harada H, Wato M, Fujiwara N. Eurytrema infection in dairy cattle. Journal of Veterinary Medicine, 1980. Berlim, v.707, n.707, p.328-331.
Headley SA, Headley SA, Saut JPE, Bassani CA, Sangioni LA, Birgel JEH, Yamamura MH. Histopathologic patterns of pancreatic lesions induced by Eurytrema coelomaticum in cattle from the central-west region of the State of Paraná, Southern Brazil. Brazilian Journal of Veterinary Patholology, 2009. Botucatu, v.2, n.1, p.3-7.
Hiridis S, Konstantinidis K, Menenakos E, Diamantis T, Papalois A, Zografos G. Preliminary Results of the Influence of Duodenojejunal Bypass in a Porcine Model of Streptozotocin-Induced Diabetes Mellitus. The Journal of Metabolic Surgery and Allied Care. 2017. Atenas, p. 1-9. doi: 10.1007/s11695-016-2086-3.
Horta PP. Distomatose pancreática e glicosúria em bovinos. A lavoura, Rio de Janeiro, v.22, n.3-4, p.157-158, 1918.
Hossa MR, Bellé TH, Furlanetto CS, Da Silva JR, Freitas FLC, Elias F. Eurytrematosis in cattle in the southwest and west Paraná. Archives of Veterinary Science, 2013. v. 18, (supl.2).
Hunt JV, Smith CCT, Wolff SP. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes. 1990. (39): 1420-1424. doi: 10.2337/diab.39.11.1420.
Ilha MR, Loretti AP, Reis AC. Wasting and mortality in beef cattle parasitized by Eurytrema coelomaticum in the State of Paraná, southern Brazil Vet. Parasitol., 2005. 133, pp. 49-60. doi: 10.1016/j.vetpar.2005.02.013.
Ishii Y, Koga M, Fujino T, Higo H, Ishibashi J, Oka K, Saito S. Human infection with the pancreas fluke, Eurytrema pancreaticum. American Journal of Tropical Medicine and Hygiene, 1983. Japão, v.32, n.5, p.1019–1022. doi: 10.4269/ajtmh.1983.32.1019.
Jacques-Silva MC, Nogueira CW, Broch LC, Flores EM, Rocha JB. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Toxicol. Appl. Pharmacol., 2001. v. 88, p. 119-25. doi: 10.1034/j.1600-0773.2001.d01-92.x.
Lazarotto AK, Barba YC, Tonel D, Machado C, Barcelos RCS, Rosa HZ, Bürger ME, Benvegnú DM. Vitamin C analysis and nutritional status of children and adolescents exposed to secondhand smoke. Brazilian Journal of Development, 2020. v. 6, p. 53894-53907. doi:10.34117/bjdv6n7-873.
Lehninger TM, Nelson DL, Cox MM. Princípios de Bioquímica. 6ª Edição, 2014. Ed. Artmed.
Leontovich AA, Intine RV, Sarras J, Michael P. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. Rochester, 2016. p. 1- 10. doi: 10.1155/2016/2860780.
Li DL, Lu SS. Prevalence of intestine parasites in children in Henan province. J. Prev. Med., 2011. 22, pp. 431-434. doi: 10.1179/1364859411Y.0000000040.
Liu J, Wang A, Li L, Huang Y, Xue P, Hao A. Oxidative stress mediates hippocampal neuron death in rats after lithium–pilocarpine-induced status epilepticus. Seizure, 2010. v. 19, no. 3, pp. 165–172. doi: 10.1016/j.seizure.2010.01.010.
Lima MFC, Suassuna ACD, Ahid SMM, Filgueira KD. Análise das alterações anatomopatológicas durante a inspeção post mortem em bovinos no abatedouro frigorífico industrial de mossoró, rio grande do norte. Ciência Animal, 2007. 17(2):113-116.
Ma J, He SW, Li H, Guo QC, Pan WW, Wang XJ, Zhang J, Liu LZ, Liu W, Liu Y. First survey of helminths in adult goats in Hunan Province, China. Tropical Biomedicine 2014. 31(2): 261–269.
Martin OC. The incidence of Eurytrema pancreaticum in dairy cattle at the Dtrifarm. Philippine Journal of Science, Manila, 1972. v.56, p.25-34, 1972.
Mattos Júnior DG, Vianna SS. O Eurytrema coelomaticum (Trematoda: Dicrocoeliidae) no Brasil. Arquivos Fluminenses de Medicina Veterinária, Rio de Janeiro, 1987. v.2, n.1, p.3-7.
Mendes RE, Schneider AF, Werlich DE, Lucca NJ, Lorenzett MP, Pilati C. Estudo anatomopatológico em tecidos condenados pelo Serviço de Inspeção Federal (SIF) por suspeita de tuberculose. Ciência Anim Bras. 2013. 14(4):448-53. DOI: 10.5216/cab.v14i4.8581.
Mohanta UK, Ichikawa-Seki M, Hayashi K, Itagaki T. Morphological and molecular characterization of Eurytrema cladorchis parasitizing cattle (Bos indicus) in Bangladesh. Parasitol. Res. 2015. 114: 2099–2105. doi: 10.1007/s00436-015-4398-y.
Nazratun NA, Budin SB, Zaryantey AH, Mariati AR, Santhana RL, Osman M, Muhd Hanis MI, Jamaludin M. Aqueous calyxes extract of Roselle or Hibiscus sabdariffa Linn supplementation improves liver morphology in streptozotocin induced diabetic rats. Arab Journal Of Gastroenterology. Kuala Lumpur, 2017. p. 1-8.
Nousia-Arvanitakis S. Cystic fibrosis and the pancreas: recent scientific advances. Journal of Clinical Gastroenterology, 1999. v. 29, n. 2, pg.138–142. doi: 10.1097/00004836-199909000-00007.
Ogawa HA, Takehara Y, Naganawa S, Yamaguchi J, Nakaguro M. Case of human pancreatic eurytremiasis. Abdominal Radiology, Basel, 2019. v.44, p.1213-1216. doi: 10.1007/s00261-019-01925-4.
Ohkawa H, Ohishi H, Yagi K. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979. 95, 351–358. doi: 10.1016/0003-2697(79)90738-3.
Oliveira OC, Bechara GH. Aspectos microscópicos do pâncreas de bovino parasitado por Eurytrema coelomaticum. Arquivos de Biologia e Tecnologia, Curitiba, 1988. v. 31, n.2, pg. 275-279.
Park H, Park JB, Kim JH, Lee KW, Lee HS, Kim GS, Shin DY, Oh SH, Jin SM, Kim SJ. Simultaneous Subtotal Pancreatectomy and Streptozotocin Injection for Diabetes Modeling in Cynomolgus Monkeys. Transplantation Proceedings. Seoul, 2017. p. 1-8.
Pepper A. Establishment of a stringent large animal model of insulin dependent diabetes for islet autotransplantation: combination of pancreatectomy and streptozotocin. Ovid Technologies. Ontário, 2013. p. 1-10. doi: 10.1097/MPA.0b013e318264bcdd.
Pipkin JA, Cruz B, Flores RJ, Hinojosa CA, Carcoba LM, Ibarra M, Francis W, Nazarian A, O'Dell LE. Both nicotine reward and withdrawal are enhanced in a rodent model of diabetes. Psychopharmacology. 2017. El Paso, p. 1-8. 7. doi: 10.1007/s00213-017-4592-y.
Quevedo P De S, Mendes M, Felipe GP, Soares MP, Muller G, Farias NA, Da RF. Pancreatite intersticial crônica em bovino causada por Eurytrema coelomaticum. Ciência Rural, 2013. 43: 1449–1452.
Rocha FD, Teixeira VL, Pereira RC, Kaplan MAC. Diabetes Mellitus e estresse oxidativo: produtos naturais como alvo de novos modelos terapêuticos. Ver. Bras. Farm. 2006. 87(2): 49-55.
Rojo-Vazquez FA, Meana A, Valcarcel F, Martinez-Valladares M. Update on trematode infections in sheep. Vet Parasitol. 2012. 189: 15-38. doi: 10.1016/j.vetpar.2012.03.029.
Sakamoto H, Tashiro T, Watanabe S, Sakamoto T. Clinicopathological findings of cattle infected with Eurytrema coelomaticum. Bulletin of the Faculty of Agriculture Kagoshima, Kagoshima, 1980. v.30, n.2 p.117-122.
Sousa AA, Albernaz A, Sobrinho HR. Diabetes Melito tipo 1 autoimune: aspectos imunológicos. Universitas: Ciências da Saúde, Brasília, 2016. v. 14, n. 1, p. 53-65. doi: 10.5102/ucs.v14i1.3406
Schimites PI, Segat HJ, Teixeira LG, Martins LR, Mangini LT, Baccine PS, Rosa HZ, Milanesi LH, Burger ME, Soares AV. Gallic acid prevents ketamine-induced oxidative damages in brain regions and liver of rats. Neuroscience Letters. 2020. v. 714, 134560. doi.org/10.1016/j.neulet.2019.134560.
Schwertz CI, Gabriel ME, Henker LC, Bottari NB, do Carmo G, Guarda NS, Moresco RN, Machado G, Morsch VM, Schetinger MRC, Stedille FA, Baska P, Mattei V, da Silva AS, Mendes RE. Oxidative stress associated with pathological changes in the pancreas of cattle naturally infected by Eurytrema coelomaticum. Veterinary Parasitology, 2016. v.223, p.102-110. doi: 10.1016/j.vetpar.2016.04.034.
Surian CRC, Surian SRS, Carneiro C, Perosa FF, Hors VW, Fronza N, Bonassi DE, Peripolli V, Santarosa PB, Gomes TMA, Mendes RE. Eurytrema coelomaticum infection: correlation between parasite burden and impairment of pancreatic exocrine enzyme secretion. Ciência Rural, 2022 - Santa Maria, v.52:2, e20210041. doi.org/10.1590/0103-8478cr20210041.
Takaoka H, Mochizuki Y, Hirao E, Iyota N, Matsunaga K, Fujioka T. A Human case of Eurytremiasis: Demonstration of Adult Pancreatic Fluke, Eurytrema pancreaticum (Jason, 1889) in Resected Pancreas. Japanese Journal of Parasitology, 1983. Japão, v.32, n.6, p.501-508.
Tessele B, Brum JS, Barros CSL. Lesões parasitárias encontradas em bovinos abatidos para consumo humano. Pesqui. Vet. Bras. 2013. 33: 873–889.
Zheng Y, Luo X, Jing Z. Comparison of 18S ribosomal RNA gene sequences of Eurytrema coelmaticum and Eurytrema pancreaticum. Parasitol. Res. 2007. 100: 645–646. doi: 10.1007/s00436-006-0281-1.
Zyzak DB, Richardson JM, Thorpe SR, Baynes JW. Formation of reactive intermediates from Amadori compounds under physiological conditions. Archives of Biochemistry and Biophysics. 1995. 316 (10): 547-554.
Wiroreno W, Carney WP, Ansori M. Description and growth pattern of Eurytrema pancreaticum from Bos indicus from East Java. Proc. Helm. Soc. Wash. 1987. 54: 73–77.
Westermarck E, Wiberg M. Exocrine pancreatic insufficiency in the dog: Historical background, diagnosis and treatment. Topics in Companion Animal Medicine, Finlândia, 2012. v.27, n. 3, p.96-103. doi: 10.1053/j.tcam.2012.05.002.
Yamamura MH. Algumas avaliações sobre a patologia e controle da euritrematose bovina. 1989. Tese (Doutorado em Medicina Veterinária, Parasitologia Veterinária – Concentração Helmintologia Veterinária) – Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro.
Yan LY, Traber MG, Packer L. Spectrophotometric method for determination of carbonyls in oxydatively modified apolipoprotein B of human low-density lipoproteins. Anal. Biochem., 1995. v. 228, p. 349-51. doi: 10.1006/abio.1995.1362.
Yang HY, Lee TH. Antioxidant enzymes as redox-based biomarkers: a brief review. BMB Reports, 2015. v. 48, no. 4, pp. 200–208. doi: 10.5483/BMBRep.2015.48.4.274.
