Participação de HIF-1? na resistência insulínica induzida por obesidade / Participation of HIF-1? in insulin resistance obesity-induced
DOI:
https://doi.org/10.34117/bjdv7n8-179Keywords:
HIF, Obesidade, Macrófagos, Adipócito.Abstract
O presente trabalho teve por objetivo investigar a relação do HIF-1? em macrófagos e adipócitos com o agravamento do quadro clínico da obesidade e desencadeamento da resistência insulínica., a partir de um estudo de revisão sistemática da literatura. Para seleção dos artigos, foram incluídos trabalhos que investigassem a associação HIF-1? e macrófago, HIF-1? e adipócitos, e excluídos os que investigassem a relação do HIF com outros desfechos. Foram selecionados dez artigos, os quais são apresentados em uma tabela. A obesidade tem como característica fisiológica o aumento desproporcional do tecido adiposo branco, decorrente do saldo positivo de energia, desencadeando hipertrofia e hiperplasia local que dificulta a perfusão sanguínea, podendo levar a um quadro de hipóxia. A deficiência na disponibilidade de oxigênio leva a estabilização do fator induzível por hipóxia (HIF-1?) que é responsável pela ativação de genes pró-inflamatórios. A estabilização de HIF-1? nos macrófagos induz um fenótipo pró-inflamatório, enquanto nos adipócitos, resulta no aumento da produção de espécies reativas de oxigênio e na liberação de quimiocina que recrutam mais macrófagos para o local. Dessa forma ocorre um reforço contínuo da inflamação no tecido adiposo, que impede o funcionamento normal da via metabólica da insulina na célula, induzindo a resistência insulínica. A modulação do HIF-1? pode potencialmente contribuir para redução da inflamação e da resistência insulínica.
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