Aditivos naturais na cunicultura: alternativas sustentáveis aos antibióticos promotores de crescimento

Autores

  • Filipe Antônio Monteiro
  • Gabriela Hernandes Cangianelli
  • Dezirre Raiane Costa
  • Maria Luiza Rodrigues de Souza
  • Mateus Eliel Depieri
  • Gislaine Gonçalves Oliveira
  • Diogo De Oliveira Marques
  • Leandro Dalcin Castilha

DOI:

https://doi.org/10.34188/bjaerv8n2-089

Palavras-chave:

aditivos naturais, microbiota intestinal, nutrição de precisão, produção sustentável, saúde intestinal

Resumo

 

A cunicultura, voltada à criação de coelhos, destaca-se pela alta eficiência produtiva e pela carne magra, rica em proteínas e de baixo teor de gordura, sendo uma opção saudável ao consumidor. Apesar de seu potencial, a atividade enfrenta desafios como doenças infecciosas, estresse térmico e dietas desbalanceadas, agravados pela ausência de rações específicas. Diante da crescente restrição ao uso de antibióticos promotores de crescimento (APCs), alternativas naturais têm ganhado destaque. Aditivos como probióticos, prebióticos, simbióticos, enzimas, fitogênicos, óleos essenciais, ácidos orgânicos e estimulantes imunológicos demonstram efeitos positivos sobre a microbiota intestinal, imunidade, digestibilidade e desempenho zootécnico. Compostos como carvacrol, timol e eugenol apresentam ação antimicrobiana e anti-inflamatória; enzimas favorecem o aproveitamento de ingredientes fibrosos; e o ácido butírico melhora a integridade intestinal. Apesar do custo inicial mais elevado, tais aditivos promovem menor mortalidade, melhor conversão alimentar e valorização comercial, principalmente em produções livres de antibióticos. A sustentabilidade é reforçada pelo uso de compostos biodegradáveis e subprodutos agroindustriais. Entretanto, a escassez de estudos específicos com coelhos e a variação nos resultados exigem mais pesquisa e validação. O futuro da cunicultura sustentável exige integração entre nutrição de precisão, inovação tecnológica e políticas públicas voltadas à segurança alimentar e ao bem-estar animal.

 

Biografia do Autor

Filipe Antônio Monteiro

Gabriela Hernandes Cangianelli

Dezirre Raiane Costa

Maria Luiza Rodrigues de Souza

Mateus Eliel Depieri

Gislaine Gonçalves Oliveira

Diogo De Oliveira Marques

Leandro Dalcin Castilha

Referências

Abdelsalam, M., & Fathi, M. (2023). Improving productivity in rabbits by using some natural feed additives under hot environmental conditions—A review. Animal bioscience, 36(4), 540.

Abdel-Wareth, A. A., & Metwally, A. E. (2020). Productive and physiological response of male rabbits to dietary supplementation with thyme essential oil. Animals, 10(10), 1844.

Ao, T., Cantor, A., Pescatore, A., Ford, M., Pierce, J., & Dawson, K. (2009). Effect of enzyme supplementation and acidification of diets on nutrient digestibility and growth performance of broiler chicks.. Poultry science, 88 1, 111-7. https://doi.org/10.3382/ps.2008-00191.

Ashaolu, T., Ashaolu, J., & Adeyeye, S. (2020). Fermentation of prebiotics by human colonic microbiota in vitro and short‐chain fatty acids production: a critical review. Journal of Applied Microbiology, 130. https://doi.org/10.1111/jam.14843.

Ashour, G., Barakat, S., El-Azeem, N., Mageed, E., Younan, G., El-Sayed, H., Morsy, S., & Abdel-Rahman, S. (2024). Physiological and Productive Responses to Dietary Supplementation of Chlorella vulgaris in Growing Rabbits. World's Veterinary Journal. https://doi.org/10.54203/scil.2024.wvj68.

Ayyat, M., Al‐Sagheer, A., El-Latif, K., & Khalil, B. (2018). Organic Selenium, Probiotics, and Prebiotics Effects on Growth, Blood Biochemistry, and Carcass Traits of Growing Rabbits During Summer and Winter Seasons. Biological Trace Element Research, 186, 162 - 173. https://doi.org/10.1007/s12011-018-1293-2.

Beaumont, M., Mussard, E., Barilly, C., Lencina, C., Gress, L., Painteaux, L., Gabinaud, B., Cauquil, L., Aymard, P., Canlet, C., Paës, C., Knudsen, C., & Combes, S. (2021). Developmental Stage, Solid Food Introduction, and Suckling Cessation Differentially Influence the Comaturation of the Gut Microbiota and Intestinal Epithelium in Rabbits. The Journal of Nutrition, 152, 723 - 736. https://doi.org/10.1093/jn/nxab411.

Behera, D., Chizari, S., Shaw, L., Porter, M., Hensleigh, R., Xu, Z., Zheng, X., Connolly, L., Roy, N., Panas, R., Saha, S., Zheng, X., Hopkins, J., Chen, S., & Cullinan, M. (2020). Current challenges and potential directions towards precision microscale additive manufacturing – Part IV: Future perspectives. Precision Engineering. https://doi.org/10.1016/j.precisioneng.2020.12.014.

Cai, F., Huang, M., Liu, W., Wan, X., Qiu, K., & Xu, X. (2025). Dietary addition of compound organic acids improves the growth performance, carcass trait, and body health of broilers. Frontiers in Nutrition, 12. https://doi.org/10.3389/fnut.2025.1536606.

Cardinali, R., Cullere, M., Bosco, A., Mugnai, C., Ruggeri, S., Mattioli, S., Castellini, C., Marinucci, M., & Zotte, A. (2015). Oregano, rosemary and vitamin E dietary supplementation in growing rabbits: Effect on growth performance, carcass traits, bone development and meat chemical composition. Livestock Science, 175, 83-89. https://doi.org/10.1016/J.LIVSCI.2015.02.010.

Chen, X., Shang, S., Yan, F., Jiang, H., Zhao, G., Tian, S., Chen, R., Chen, D., & Dang, Y. (2023). Antioxidant Activities of Essential Oils and Their Major Components in Scavenging Free Radicals, Inhibiting Lipid Oxidation and Reducing Cellular Oxidative Stress. Molecules, 28. https://doi.org/10.3390/molecules28114559.

Crespo, R., Alfonso, C., Barrio, A., García-Ruiz, A., Marco, M., & Nicodemus, N. (2020). Effect of feed restriction on performance, carcass yield and nitrogen and energy balance in growing rabbits. Livestock Science. https://doi.org/10.1016/J.LIVSCI.2020.104278.

Elazab, M., Khalifah, A., Elokil, A., Elkomy, A., Rabie, M., Mansour, A., & Morshedy, S. (2022). Effect of Dietary Rosemary and Ginger Essential Oils on the Growth Performance, Feed Utilization, Meat Nutritive Value, Blood Biochemicals, and Redox Status of Growing NZW Rabbits. Animals : an Open Access Journal from MDPI, 12. https://doi.org/10.3390/ani12030375.

El-Deep, M., Amber, K., Eid, Y., Aboelenin, S., Soliman, M., Sakr, M., & Dawood, M. (2021). The Influence of Chicken Egg Lysozyme or Zinc-Bacitracin Antibiotic on the Growth Performance, Antibacterial Capacity, Blood Profiles, and Antioxidative Status of Rabbits: A Comparative Study. Animals : an Open Access Journal from MDPI, 11. https://doi.org/10.3390/ani11061731.

El-Nomeary, Y., Abedo, A., Salman, F., Sedera, A., Nasr, S., Nassar, S., & Ibraheim, S. (2020). EFFECT OF ADDING CINNAMON, GARLIC AND JUNIPER ESSENTIAL OILS ON PRODUCTIVE PERFORMANCE OF NEW-ZEALAND WHITE RABBITS. Egyptian Journal of Nutrition and Feeds. https://doi.org/10.21608/EJNF.2020.148125.

Fang, S., Chen, X., Ye, X., Zhou, L., Xue, S., & Gan, Q. (2020). Effects of Gut Microbiome and Short-Chain Fatty Acids (SCFAs) on Finishing Weight of Meat Rabbits. Frontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.01835.

Gidenne, T. (2015). Dietary fibres in the nutrition of the growing rabbit and recommendations to preserve digestive health: a review.. Animal : an international journal of animal bioscience, 9 2, 227-42 . https://doi.org/10.1017/S1751731114002729.

Gidenne, T., Garreau, H., Drouilhet, L., Aubert, C., & Maertens, L. (2017). Melhorando a eficiência alimentar na produção de coelhos: uma revisão sobre aspectos nutricionais, técnico-econômicos, genéticos e ambientais. Ciência e Tecnologia da Alimentação Animal , 225, 109-122. https://doi.org/10.1016/J.ANIFEEDSCI.2017.01.016 .

Gonzalez, F., Jiang, C., & Patterson, A. (2016). An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease.. Gastroenterology, 151 5, 845-859 . https://doi.org/10.1053/j.gastro.2016.08.057.

Guo, M., Wu, F., Hao, G., Qi, Q., Li, R., Li, N., Wei, L., & Chai, T. (2017). Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits. Frontiers in Immunology, 8. https://doi.org/10.3389/fimmu.2017.00354.

Jimoh, O., Temidayo, D., Ololade, O., Abosede, O., & Adekunle, O. (2022). Effect of phytogenic supplements on the reproductive physiology and metabolic hormones of rabbits exposed to heat stress conditions.. Journal of thermal biology, 112, 103438 . https://doi.org/10.1016/j.jtherbio.2022.103438.

Karásková, K., Suchý, P., & Strakova, E. (2016). Current use of phytogenic feed additives in animal nutrition: a review. Czech Journal of Animal Science, 60, 521-530. https://doi.org/10.17221/8594-CJAS.

Li, C., Niu, J., Liu, Y., Li, F., & Liu, L. (2021). The effects of oregano essential oil on production performance and intestinal barrier function in growing Hyla rabbits. Italian Journal of Animal Science, 20(1), 2165-2173.

Liang, Z., Chen, F., Park, S., Balasubramanian, B., & Liu, W. (2022). Impacts of Heat Stress on Rabbit Immune Function, Endocrine, Blood Biochemical Changes, Antioxidant Capacity and Production Performance, and the Potential Mitigation Strategies of Nutritional Intervention. Frontiers in Veterinary Science, 9. https://doi.org/10.3389/fvets.2022.906084.

Mancini, S., & Paci, G. (2021). Probiotics in Rabbit Farming: Growth Performance, Health Status, and Meat Quality. Animals : an Open Access Journal from MDPI, 11. https://doi.org/10.3390/ani11123388.

Mattioli, S., Bosco, A., Maranesi, M., Petrucci, L., Rebollar, P., & Castellini, C. (2019). Dietary fish oil and flaxseed for rabbit does: fatty acids distribution and Δ6-desaturase enzyme expression of different tissues.. Animal : an international journal of animal bioscience, 1-9 . https://doi.org/10.1017/S175173111900020X.

Mohammed, A., Elshaer, A., Sareh, P., Elsayed, M., & Hassanin, H. (2020). Additive Manufacturing Technologies for Drug Delivery Applications.. International journal of pharmaceutics, 119245 . https://doi.org/10.1016/j.ijpharm.2020.119245.

Oso, A., Idowu, O., Haastrup, A., Ajibade, A., Olowonefa, K., Aluko, A., Ogunade, I., Osho, S., & Bamgbose, A. (2013). Growth performance, apparent nutrient digestibility, caecal fermentation, ileal morphology and caecal microflora of growing rabbits fed diets containing probiotics and prebiotics. Livestock Science, 157, 184-190. https://doi.org/10.1016/J.LIVSCI.2013.06.017.

Phuoc, T., & Jamikorn, U. (2016). Effects of probiotic supplement (Bacillus subtilis and Lactobacillus acidophilus) on feed efficiency, growth performance, and microbial population of weaning rabbits. Asian-Australasian Journal of Animal Sciences, 30, 198 - 205. https://doi.org/10.5713/ajas.15.0823.

Prudius, T., Hutsol, A., & Hutsol, N. (2021). SLAUGHTER INDEXES, MORPHOLOGICAL COMPOSITION OF CARCASES AND MUSCLE TISSUE QUALITY OF REARING PIGS UNDER FEED ADDITIVE "ACTIVO" SUPPLEMENTATION. Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology. https://doi.org/10.36359/scivp.2021-22-2.33.

Qi, L. (2013). Effects of Enramycin on Growth Performance and Diarrhea of Rabbits. Chinese Journal of Rabbit Farming.

Ramón-Moragues, A., Vaggi, C., Franch-Dasí, J., Martínez-Paredes, E., Peixoto-Gonçalves, C., Ródenas, L., López-Luján, M., Marín-García, P., Blas, E., Pascual, J., & Cambra-López, M. (2024). Screening of Organic Acid Type and Dosage in Drinking Water for Young Rabbits. Animals : an Open Access Journal from MDPI, 14. https://doi.org/10.3390/ani14152177.

Salim, A., Butler, M., Blaskovich, M., Henderson, I., & Capon, R. (2023). Natural products as anthelmintics: safeguarding animal health.. Natural product reports. https://doi.org/10.1039/d3np00019b.

Savassi, B., Cordeiro, B., Silva, S., Oliveira, E., Belo, G., Figueiroa, A., Queiroz, M., Faria, A., Alves, J., Da Silva, T., Campos, G., Esmerino, E., Rocha, R., Freitas, M., Silva, M., Cruz, A., Vital, K., Fernandes, S., Cardoso, V., Acurcio, L., Jan, G., Loir, L., Gala-García, A., Carmo, F., & Azevedo, V. (2021). Lyophilized Symbiotic Mitigates Mucositis Induced by 5-Fluorouracil. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.755871.

Silveira, R., Roque-Borda, C., & Vicente, E. (2021). Antimicrobial peptides as a feed additive alternative to animal production, food safety and public health implications: An overview. Animal Nutrition, 7, 896 - 904. https://doi.org/10.1016/j.aninu.2021.01.004.

Stoev, S. (2024). Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1335779.

Sun, C., Wang, Z., Li, Y., & Huang, J. (2024). Antibiotic resistance spectrums of Escherichia coli and Enterococcus spp. strains against commonly used antimicrobials from commercial meat-rabbit farms in Chengdu City, Southwest China. Frontiers in Veterinary Science, 11. https://doi.org/10.3389/fvets.2024.1369655.

Vučurović, D., Bajić, B., Trivunović, Z., Dodić, J., Zeljko, M., Jevtić-Mučibabić, R., & Dodić, S. (2024). Biotechnological Utilization of Agro-Industrial Residues and By-Products—Sustainable Production of Biosurfactants. Foods, 13. https://doi.org/10.3390/foods13050711.

Wang, J., Zhao, K., Kang, Z., Wang, M., Chen, Y., Fan, H., Xia, S., & Lai, S. (2022). The Multi-Omics Analysis Revealed a Metabolic Regulatory System of Cecum in Rabbit with Diarrhea. Animals : an Open Access Journal from MDPI, 12. https://doi.org/10.3390/ani12091194.

Wesguerber, T., Pinto, A. C. P., Santos, A. C. M., Pierre, L. dos S. S., Rocha, L. S., Faria, R. D. R. de, & Galeb, L. do A. G. (2024). A influência do uso de antimicrobianos na produção animal e o impacto nos produtos derivados destinados à alimentação humana e animal. Brazilian Journal of Animal and Environmental Research, 7(3), e71369. https://doi.org/10.34188/bjaerv7n3-012

Wongnaa, C., Afful-Kwadam, K., Asempah, M., Hagan, M., & Awunyo-Vitor, D. (2023). Is it profitable and viable to invest in commercialization of rabbit production? Implication on Rural Enterprise Development. Sustainable Technology and Entrepreneurship. https://doi.org/10.1016/j.stae.2023.100048.

Yan, X., Bai, L., Lv, J., Qi, P., Song, X., & Zhang, L. (2024). Effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the Structure and Function of the Intestinal Flora in Rabbits Undergoing Hepatic Artery Infusion Chemotherapy. Biology, 13. https://doi.org/10.3390/biology13050327.

Zhang, Y., Wang, X., Zeng, Q., Deng, Y., Xie, P., Zhang, C., & Huang, L. (2023). A new insight into synergistic effects between endogenous phenolic compounds additive and α-tocopherol for the stability of olive oil.. Food chemistry, 427, 136667 . https://doi.org/10.1016/j.foodchem.2023.136667.

Zhou, L., Miller, J., Vezza, J., Mayster, M., Raffay, M., Justice, Q., Tamimi, Z., Hansotte, G., Sunkara, L., & Bernat, J. (2024). Additive Manufacturing: A Comprehensive Review. Sensors (Basel, Switzerland), 24. https://doi.org/10.3390/s24092668.

Zhou, X., Qiao, K., Wu, H., & Zhang, Y. (2023). The Impact of Food Additives on the Abundance and Composition of Gut Microbiota. Molecules, 28. https://doi.org/10.3390/molecules28020631.

Zotte, D., & Szendrő, Z. (2011). The role of rabbit meat as functional food.. Meat science, 88 3, 319-31 . https://doi.org/10.1016/j.meatsci.2011.02.017.

Downloads

Publicado

2025-07-08

Como Citar

Monteiro, F. A., Cangianelli, G. H., Costa, D. R., Souza, M. L. R. de, Depieri, M. E., Oliveira, G. G., Marques, D. D. O., & Castilha, L. D. (2025). Aditivos naturais na cunicultura: alternativas sustentáveis aos antibióticos promotores de crescimento. Brazilian Journal of Animal and Environmental Research, 8(2), e80822. https://doi.org/10.34188/bjaerv8n2-089

Edição

Seção

Artigos originais