Uso de fitoestrogenios no controle reprodutivo da cães não domiciliados
DOI:
https://doi.org/10.34188/bjaerv8n2-049Palavras-chave:
phytoestrogens, coumestrol, reproductive control, bitchesResumo
Stray dogs represent a public health problem in large cities, both due to the zoonotic diseases they transmit and the injuries they cause. The high economic investment in treatment and eradication does not provide stable results, so low-cost auxiliary methods are required to control their reproduction. Our objective was to evaluate the potential use of coumestrol to alter the ovarian and hormonal characteristics of orally treated adult female dogs. Eight adult mixed-breed dogs were used, 3 of which were treated in a single dose with the vehicle (5 μl of DMSO) and the remaining 5 with the phytoestrogen (40 μg in 5 μl of DMSO) in a 2-g kibble of commercial food. The estrous cycle was monitored by cytology of exfoliative vaginal swabs and variations in circulating progesterone for 12 months. At the end of treatment, the ovaries were removed for histopathological evaluation. These data indicate that Coumestrol-treated bitches have altered exfoliative vaginal cytology, reflecting a rupture between follicular and endometrial maturation, as well as differences in Progesterone synthesis regulation.
Referências
BELSARE, ÇA., VANAK, A.T. (202). Modelling the challenges of managing free-ranging dog populations. Sci. Rep. 10:18874. https://doi.org/10.1038/s41598-020-75828-6
BRANDLI, S.P., PALM, J., KOWALESKI, M.P., REICHLER, I.M. (2021). Long-term effect of repeated deslorelin acetate treatment in bitches for reproductive control. Theriogenology 173: 73. https://doi.org/10.1016/j.theriogenology.2021.07.015
DJOKIC, V., FREDDI, L., DE MASSI, F., LAHTI, E., VAN DEN ESKER, M., WHATMORE A., HAUGHEY, A., FERREIRA, A.C., GAROFOLO, G., MELZER, F., SACCHINI, F., KOETS, A., WYLLIE, S., FONTBONNE, A., GIRAULT, G., FERREIRA VICENTE, A., MCGIVEN, J., PONSART, C. (2023). The emergence of Brucella canis as a public health threat in Europe: what we know and what we need to learn. Emerg. Microbes Infect. 12:2249126. https://doi.org/10.1080/22221751.2023.2249126
DUNCAN-SUTHERLAND, N., LISSAMAN, A.C., SHEPHERD, M., KOOL, B. (2022). Systematic review of dog bite prevention strategies. Inj. Prev. 28:288-297. https://doi.org/10.1136/injuryprev-2021-044477
ESCAREÑO-SÁNCHEZ, L.M., RAMIREZ ORTIZ, R.C., ROCHIM BERUMEN, F.L., GUTIERREZ PIÑA, F.J., RINCON DELGADO, R.M. (2023). The importance of the management of the stray canine population in Mexico: perspectives and challenges. Rev. Iberoamer. Ciencias Biol. Agropec. 12: 124. https://doi.org/10.23913/ciba.v12i24.124
FAGERSTONE, K.A., MILLER, L.A., KILLIAN, G., YODER, C.A. (2010). Review of issues concerning the use of reproductive inhibitors, with particular emphasis on resolving huma-wildlife conflicts in North America. Integr. Zool. 5:15. https://doi.org/10.1111/j.1749-4877.2010.00185.x
IMMEGART, H.M., THRELFALL, W.R. (2000). Evaluation of intratesticular injection of glycerol for nonsurgical sterilization of dogs. A. J. Vet. Res. 61: 544. https://doi.org//10.2460/ajvr.2000.61.544
JANA, K., SAMANTA, P.K. (2007). Sterilization of male stray dogs with a single intratesticular injection of calcium chloride: a dose-dependent study. Contraception. 75:390. https://www.doi.org/10.1016/j.contraception.2007.01.022
LINDH, LINDEBERG, H., BANTING, A., BANTING, S., SAINMAA, S., BEASLEY, S., KORHONEN, H.T., PELTONIEMI, O.A.T. (2020). Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs. Theriogenology 152: 53. https://doi.org/10.1016/j.theriogenology.2020.04.009
MOHAMED, A., FATHI, M., EL-SHAHAT, K.H., SHAMAA, A.A., BAHR, M.M., EL-SAIED, M.A. 2024). Chemical castration in dogs using calcium chloride: effects on testicular hemodynamics and semen characteristic and serum levels of testosterone. BMC Veterinary Res. 20:511. https://www.doi.org/10.1186/s12917-024-0435-9
NAZ, R.K., TALWAR, G.P. (1981). Immunological sterilization of male dogs by BCG. Int. J. Androl. 4:111. https://doi.org/10.1111/j.1365-2605.1981.tb00697.x.
PEÑA-CORONA, S.I., LEON-ORTIZ, P., VILLANUEVA-MARTINEZ, M., MENDOZA RODRIGUEZ, C.A., MARTIEZ-MAYA, J.J., SERRANO, H., VARGAS-ESTRADA, D., VILLA-GODOY, A. (2022). Administration of coumestrol and/or Dimethyl Sulfoxide affects vaginal epithelium and sex hormones in female dogs. Indian J. Anim. Res. Doi: https://doi.org/10.18805/IJAR.BF-1506.
PEREZ-RIVERO J.J., MARTINEZ-MAYA, J.J., PEREZ-MARTINEZ, M., AGUILAR-SETIEN, A., GARCIA-SUAREZ, M.D., SERRANO, H. (2009). Phytoestrogen treatment induces testis alterations in dogs: Potential use in population control. Vet. Res. Commun. 33:87. https://www.doi.org/10.1007/s11259-008-9077-3
RAFATMAH, D., MOGHEISEH, A., ESHGHI, D. (2019). Chemical sterilization with intratesticular administration of zinc gluconate in adult dogs: a preliminary report. Basic Clin. Androl. 29:12. https://doi.org/10.1186/s12610-019-0092-8
SERRANO, H., GARCÍA-SUÁREZ, M.D. (2001). Ovarian alterations in bitches induced by active immunization against pig oocyte proteins. Veterinaria Mex. 32: 221. https://www.redalyc.org/articulo.oa?id=42332309
SERRANO, H., MORA-RAMIRO, G., PEÑA-CORONA, S., LEON-ORTIZ, P., SALAME-MENDEZ, A., MENDIETA-MARQUES, E., GOMEZ-OLIVARES, J., GARCIA-SUAREZ, M.D. (2014). Acute oral coumestrol treatment induces sperm and sex steroid alterations in mice. Cell Biol. 2:36. https://www.doi.org/10.1164/j.cb.20140204.12
SERRANO, H., PEREZ-RIVERO, J.J., AGUILAR-SETIEN, A., DE PAZ, O., VILLA-GODOY, A. (2007). Vampire bat reproductive control by a naturally occurring phytooestrogen. Reprod. Fertil. Develop. 19:470.
SERRANO, H., PEREZ-RIVERO, J.J., MARTINEZ-MAYA, J.J., AGUILAR-SETIEN, A., PEREZ-MARTINEZ, M., GARCIA-SUAREZ, M.D. (2008). Fluorescence and immunohistological detection of estrogen receptors in dog testis and epidydimis after oral coumestrol administration. Neuroendocrinol. Lett 29:977.
SOUZA-SILVA, S., OLIVEIRA DE MACEDO, L., CARDOSO PESSOA DE OLIVEIRA, J., CAMARA ALVES, L., APARECIDA DE CARVALHO, G., NASCIMENTO RAMOS, R.A. (2023). Canine visceral leishmaniasis: risk factors and spatial analysis in an endemic area of Northeastern Brazil. Rev. Bras Parasitol Vet. 32:e003223. https://doi.org/10.1590/S1984-29612023029
TANG D, CHEN M, HUANG X, ZHANG G, ZENG L, ZHANG G, WU S, WANG Y (2023). SRplot: A free online platform for data visualization and graphing. PloS One. 18:e0294236. https://www.doi/10.1371/journal.pone.0294236
TIDMAN, R., THUMBI, S.M., WALLACE, R., DE BALOG, K., IWAR, V., DIEUZY-LABAYE, I., SONG, J., SHADOMY, S., QIU, Y., TORRES, G., HUTCHISON, J., ABELA-RIDDER, B., BOTE, K., BEECHING, S., CRONIN, K., TREES, A. (2022). United against rabies Forum: The One Health Concept at work. Front. Public Health 10: 854419. https://doi.org/10.3389/fpubh.2022.854419
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