Evaluation of the hypoglycemic, hypolipidemic and antioxidant activities of Phoenix dactylifera l. Date seeds extract in high fructose diet-induced diabetic rats
DOI:
https://doi.org/10.34188/bjaerv8n1-027Palavras-chave:
diabetes, fructose, Phoenix dactylifera L. seeds extract, metabolism, ratsResumo
Diabetes is a growing global epidemic, necessitating effective management to prevent long-term complications. Natural substances are increasingly explored as alternatives to synthetic drugs due to their affordability and lower risk of side effects. This study investigates the qualitative composition and the hypoglycemic, hypolipidemic, and antioxidant activities of date seed extract (Phoenix dactylifera L.) in diabetic rats fed a high-fructose diet. Male rats were divided into four groups (n=6): Control (C, standard diet), Fructose Diabetic (FD, 60% fructose diet), and Control and Diabetic groups receiving daily 30 mL of aqueous date seed extract (C-aqDS, FD-aqDS). Weight gain, food and energy intake were monitored, while blood samples were analyzed for biochemical and oxidant/antioxidant markers. High-fructose consumption significantly increased body weight, energy intake, and apparent nutritional efficiency, while food intake remained unchanged. Biochemical markers, including glucose, glycated hemoglobin, uric acid, urea, creatinine, lipids, and liver enzymes, were elevated in FD rats compared to controls. Oxidative stress markers (MDA, PC) were increased, and antioxidant markers (catalase, SOD, GSH) decreased. Treatment with date seed extract significantly mitigated these abnormalities, reducing weight, biochemical parameters, and oxidative stress markers while enhancing antioxidant defenses. This study highlights the richness of date seed aqueous extract in bioactive compounds and its ability to alleviate early diabetic complications and oxidative stress in high-fructose-induced diabetic rats. These findings suggest its potential as a functional food for diabetes management.
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