Creatinina: revisión de su utilidad y alcances como marcador de lesión renal
Creatinine: review of its usefulness and scope as a marker of kidney injury
DOI:
https://doi.org/10.34188/bjaerv5n3-040Palavras-chave:
caninos, riñones, lesión renal, biomarcador, creatininaResumo
La creatinina es un residuo orgánico generado a partir de la creatina fosfato. Su determinación es útil en medicina humana y veterinaria y ha reemplazado la medición directa de la tasa de filtración glomerular. Esta revisión pretende exponer diferentes postulaciones en relación a la utilidad de creatinina como marcador confiable de lesión renal. Se discutirá sobre aquellas que afirman que los indicadores serológicos, comúnmente utilizados como creatinina sérica, urea sérica y clearence de creatinina, no son lo suficientemente sensibles y específicos para detectar injuria renal y otras que sostienen que la creatinina, medida por tecnología punto de interés, es un buen predictor de injuria renal aguda. Si bien ésta, como único marcador de función y lesión renal, no es sensible ni específica de manera puntual, su uso como herramienta de predicción y diagnóstico de injuria renal, dada su accesibilidad y practicidad, la convierten en un instrumento útil cuando se la combina con otras herramientas diagnósticas en medicina veterinaria.
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