Combination of an analgesic and anti-inflammatory to avoid bleaching-induced tooth sensitivity: a randomized, triple-blind clinical trial / Combinação de um analgésico e antiinflamatório para evitar a sensibilidade dental induzida pelo clareamento: um ensaio clínico randomizado triplo-cego

Authors

  • Camila Basso Alpini Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Fabiana Scarparo Naufel
  • Alessandra Reis
  • Vera Lucia Schmitt
  • Leonardo de Almeida
  • Camillo Anauate-Netto
  • Bianca Medeiros Maran
  • Eloisa Andrade de Paula

DOI:

https://doi.org/10.34117/bjdv6n8-210

Keywords:

Dentin Sensitivity, Hydrogen Peroxide, Tooth Bleaching, Clinical Trial.

Abstract

induced tooth sensitivity (TS). This trial assed if the combination of an analgesic and an anti-inflammatory could reduce bleaching-induced TS. A parallel, placebo-controlled, triple-blind, randomized trial was conducted on 115 healthy adults. The patients received the association of acetaminophen 750 mg/ ketorolac tromethamine 10 mg or placebo, 1 h before the in-office bleaching (35% hydrogen peroxide), and extra doses every 8 h for 48 h. The TS was recorded on VAS 0-10 and NRS 0-4 scales, during bleaching and 1 to 48 h post-bleaching. The color was measured before and one month after dental bleaching using two visual shade guides and spectrophotometer. An intent-to-treat analysis was used to analyze data from all patients who were randomly assigned. No significant difference (p=0.41) in the absolute risk of TS between the acetaminophen/ketorolac group (72%; 95% CI 60 to 82) and placebo (79%; 95% CI 68 to 89) with a relative risk of 0.92; 95% CI 0.7 to 1.1. The mean difference in intensity of TS for VAS was lower in the acetaminophen/ketorolac group in the periods 12 to 24 h (-0.7) and 24 to 48 h (-0.4). A whitening effect was observed in both groups with no statistically significant difference (p>0.05). The administration of the association ketorolac/acetaminophen prior to in-office bleaching did not reduce the risk of TS but reduced the intensity of TS after 12 h in a very small magnitude. 

clinicaltrial.gov NCT03343392.

 

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Published

2020-08-14

How to Cite

Alpini, C. B., Naufel, F. S., Reis, A., Schmitt, V. L., Almeida, L. de, Anauate-Netto, C., Maran, B. M., & Paula, E. A. de. (2020). Combination of an analgesic and anti-inflammatory to avoid bleaching-induced tooth sensitivity: a randomized, triple-blind clinical trial / Combinação de um analgésico e antiinflamatório para evitar a sensibilidade dental induzida pelo clareamento: um ensaio clínico randomizado triplo-cego. Brazilian Journal of Development, 6(8), 57135–57155. https://doi.org/10.34117/bjdv6n8-210

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Section

Original Papers