Aplicação dermatológica de subprodutos de citrus: os achados da literatura
DOI:
https://doi.org/10.34119/bjhrv9n2-009Keywords:
Citrus, cosmética médica, sustentabilidadeAbstract
A indústria dos Citrus representa um importante setor agrícola e econômico, porém gera grandes volumes de resíduos, como cascas, bagaços, sementes e folhas. Esses subprodutos apresentam compostos bioativos de interesse farmacológico e cosmético, incluindo limoneno, flavonoides, limonoides e ácidos fenólicos, com reconhecidas propriedades antioxidantes, anti-inflamatórias, antimicrobianas e fotoprotetoras. Este trabalho teve como objetivo revisar a literatura científica sobre a viabilidade da utilização de derivados de Citrus sp., especialmente do limão, em formulações dermatológicas. Realizou-se uma busca sistemática nas bases Scielo, PubMed, Web of Science e Google Acadêmico, entre 2012 e 2025, utilizando os descritores Citrus, cosméticos, dermatologia e limão. Os estudos analisados demonstraram resultados promissores em diferentes abordagens, como cremes antienvelhecimento, géis fotoprotetores e formulações antiacne, com evidências de eficácia e segurança para uso tópico. Verificou-se, ainda, que os extratos cítricos contribuem para o aumento da hidratação cutânea, clareamento e estímulo à produção de colágeno. Conclui-se que os subprodutos do gênero Citrus constituem fontes sustentáveis e eficientes de princípios ativos para a cosmética médica, embora sejam necessárias pesquisas adicionais sobre a padronização de extratos e a escolha da parte vegetal mais adequada para cada aplicação dermatológica.
References
ALAQEEL, N. K. Antioxidants from different citrus peels provide protection against cancer. Braz J Biol, 84, p. 1-20, 2024. Disponível em: https://www.scielo.br/j/bjb/a/fzckhhLvscjJ4Tf4S3ybxLq/. Acesso em: 24.out.2025.
AMER, R. I. et al. Downregulation of MMP1 expression mediates the anti-aging activity of Citrus sinensis peel extract nanoformulation in UV induced photoaging in mice. Biomed Pharmacother, 138, p. 111537-111552, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S075333222100322X?via%3Dihub. Acesso em: 24.out.2025.
ANINDITA, R.; SULVAYANTI, H. Y.; INGGRAINI, M. Antibacterial Activity Test of Ethanol Extract Citrus Leaf Against Staphylococcus epidermidis. Biol Med & Nat Product Chem, 14, p. 557-565, 2025. Disponível em: https://sciencebiology.org/index.php/BIOMEDICH/article/view/755. Acesso em: 24.out.2025.
ARAÚJO-FILHO, H. G. et al. Anticancer activity of limonene: A systematic review of target signaling pathways. Phytother Res, 35, p. 4957-4970, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33864293/. Acesso em: 24.out.2025.
BARBOSA, P. P. M.; RUVIARO, A. R.; MACEDO, G. A. Comparison of different Brazilian citrus by-products as source of natural antioxidants. Food Sci Biotechnol, 27, p. 1301-1309, 2018. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170279/. Acesso em: 24.out.2025.
BARRAGÁN-OCAÑA, A. et al. Biotechnology and Bioprocesses: Their Contribution to Sustainability. Processes, 8, p. 436-446, 2020. Disponível em: https://www.mdpi.com/2227-9717/8/4/436. Acesso em: 24.out.2025.
BEN HSOUNA, A. et al. The Chemical Variability, Nutraceutical Value, and Food-Industry and Cosmetic Applications of Citrus Plants: A Critical Review. Antioxidants (Basel), 12, n. 2, Feb 14 2023. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/36830039. Acesso em: 24.out.2025.
BURNETT, C. L. et al. Safety Assessment of Citrus Peel-Derived Ingredients as Used in Cosmetics. Int J Toxicol, 40, p. 77-99, 2021. Disponível em: https://journals.sagepub.com/doi/10.1177/10915818211032617?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Acesso em: 24.out.2025.
DE AZEVEDO, A. R. G. et al. Possibilities for the application of agro-industrial wastes in cementitious materials: A brief review of the Brazilian perspective. Clean Mater, 3, p. 100040-100053, 2022. Disponível em: https://www.sciencedirect.com/science/article/pii/S277239762100040X. Acesso em: 24.out.2025.
EDDIN, L. B. et al. Neuroprotective Potential of Limonene and Limonene Containing Natural Products. Molecules, 26, p. 4535, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34361686/. Acesso em: 24.out.2025.
EL HACHLAFI, N. et al. Chemical Composition and Assessment of the Anti-Inflammatory, Antioxidant, Cytotoxic and Skin Enzyme Inhibitory Activities of Citrus sinensis (L.) Osbeck Essential Oil and Its Major Compound Limonene. Pharmaceuticals (Basel), 17, p. 1652, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/39770494/. Acesso em: 24.out.2025.
EL OMARI, N. et al. Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils. Front Biosci (Landmark Ed), 28, p. 229, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/37796709/. Acesso em: 24.out.2025.
ELENA, A. et al. The Suitability of Lipases for the Synthesis of Bioactive Compounds with Cosmeceutical Applications. Mini-Rev in Org Chem, 18, p. 515-528, 2021. Disponível em: http://www.eurekaselect.com/article/108871. Acesso em: 24.out.2025.
ESPINA, L. et al. Inactivation of Escherichia coli O157:H7 in fruit juices by combined treatments of citrus fruit essential oils and heat. Int J Food Microbiol, 159, p. 9-16, 2012. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0168160512004011?via%3Dihub. Acesso em: 24.out.2025.
FAO. FAOSTAT: New Food and Agricultural Commodity Data. 2023. Disponível em: https://www.fao.org/faostat/en/#data. Acesso em: 24.out.2025.
FUNDECITRUS. Safra de laranja 2022/23 é encerrada com produção total de 314,21 milhões de caixas. 2023. Disponível em: https://www.fundecitrus.com.br/comunicacao/noticias/integra/safra-de-laranja-202223-e-encerrada-com-producao-total-de-31421-milhoes-de-caixas/1307. Acesso em: 24.out.2025.
GNANN, G. W. M. et al. Desenvolvimento de Fitocosmético Antioxidante com Extrato de Laranja (Citrus sinensis). Singular | Saúde e Biol, 1, p. 26-32, 2020. Disponível em: http://ulbra-to.br/singular/index.php/SingularSB/article/view/81. Acesso em: 24.out.2025.
GOMES, C. et al. Biotechnology Applied to Cosmetics and Aesthetic Medicines. Cosmetics, 7, p. 33-46, 2020. Disponível em: https://www.mdpi.com/2079-9284/7/2/33. Acesso em: 24.out.2025.
GÓMEZ-MEJÍA, E. et al. A biorefinery approach for the simultaneous obtention of essential oils, organic acids and polyphenols from citrus peels: Phytochemical characterization and bioactive potential. Food Chem, 486, p. 144641, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/40347821/. Acesso em: 24.out.2025.
GUALDANI, R. et al. The Chemistry and Pharmacology of Citrus Limonoids. Molecules, 21, p. 1530, 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27845763/. Acesso em: 24.out.2025.
HAMDAN, D. et al. Chemical composition of the essential oils of variegated pink-fleshed lemon (Citrus x limon L. Burm. f.) and their anti-inflammatory and antimicrobial activities. Z Naturforsch C J Biosci, 6, p. 275-284, 2013. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24066512/. Acesso em: 24.out.2025.
HUANG, W.-Q. et al. Changing the nutrient composition and enhancing the hydrolytic enzyme activity of citrus pulp residue by cofermentation with Candida utilis and Bacillus subtilis. Process Biochem, 107, p. 83-90, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S1359511321001483. Acesso em: 24.out.2025.
ILSA. Produção Brasileira de Citros. 2022. Disponível em: https://ilsabrasil.com.br/producao-brasileira-de-citros/. Acesso em: 24.out.2025.
JORGE, N.; SILVA, A. C.; ARANHA, C. P. M. Antioxidant activity of oils extracted from orange (Citrus sinensis) seeds. An Acad Bras Cienc, 88, p. 951-958, 2016. Disponível em: https://www.scielo.br/j/aabc/a/KrNkKFmndrn5m6vJ8zq97tz/#:~:text=The%20antioxidant%20activity%20ranged%20from,%25%20(Pera%2Drio). Acesso em: 24.out.2025.
KHARTODE, P. et al. Formulation and Evaluation of Face Serum Containing Citrus Limon and Ashwagandha. IJSAT, 16, p. 1-12, 2025. Disponível em: https://www.ijsat.org/research-paper.php?id=2829. Acesso em: 24.out.2025.
KLIMEK-SZCZYKUTOWICZ, M.; SZOPA, A.; EKIERT, H. Citrus limon (Lemon) Phenomenon-A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies. Plants (Basel), 9, p. 119-142, 2020. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020168/. Acesso em: 24.out.2025.
LV, X. et al. Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health. Chem Cent J, 9, p. 68-81, 2015. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690266/. Acesso em: 24.out.2025.
MANCONI, M. et al. Chemical characterization of Citrus limon var. pompia and incorporation in phospholipid vesicles for skin delivery. Int J Pharm, 506, p. 449-457, 2016. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0378517316302976?via%3Dihub. Acesso em: 24.out.2025.
MANSOOR, K. et al. Plants with cosmetic uses. Phytother Res, 37, n. 12, p. 5755-5768, Dec 2023. Disponível em: https://www.ncbi.nlm.nih.gov/pubmed/37770185. Acesso em: 24.out.2025.
MARTINIDOU, E. et al. Comparative Evaluation of Secondary Metabolite Chemodiversity of Citrus Genebank Collection in Greece: Can the Peel be More than Waste? J Agric Food Chem, 72, p. 9019-9032, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38613500/. Acesso em: 24.out.2025.
MUKESH, B.; TILOTMA, S. Formulation and evaluation of sunscreen spray gel with lime peel extract (Citrus aurantifolia). WJBPHS, 1, p. 224-234, 2025. Disponível em: https://zenodo.org/records/17338084. Acesso em: 24.out.2025.
OTANG, W. M.; AFOLAYAN, A. J. Antimicrobial and antioxidant efficacy of Citrus limon L. peel extracts used for skin diseases by Xhosa tribe of Amathole District, Eastern Cape, South Africa. S Afr J Bot, 102, p. 46-49, 2016. Disponível em: https://www.sciencedirect.com/science/article/pii/S0254629915003610. Acesso em: 24.out.2025.
PANCHE, A. N.; DIWAN, A. D.; CHANDRA, S. R. Flavonoids: an overview. J Nutr Sci, 5, p. 47-61, 2016. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465813/. Acesso em: 24.out.2025.
PARHIZ, H. et al. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res, 29, p. 323-331, 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25394264/. Acesso em: 24.out.2025.
PIAO, M. J. et al. Protective effect of Korean Citrus limon pulp ethanol extract on ultraviolet B-induced senescent keratinocytes. Biotechnol Bioprocess Eng, p. 323-331, 2025. Disponível em: https://doi.org/10.1007/s12257-025-00229-3. Acesso em: 24.out.2025.
PIRES, T. C. M.; RIBEIRO, M. G. T. C.; MACHADO, A. A. S. C. EXTRAÇÃO DO R-(+)-LIMONENO A PARTIR DAS CASCAS DE LARANJA: AVALIAÇÃO E OTIMIZAÇÃO DA VERDURA DOS PROCESSOS DE EXTRAÇÃO TRADICIONAIS. Quim Nova, 41, p. 355-365, 2018. Disponível em: https://www.scielo.br/j/qn/a/gcqrQGBcs5JZfQrD4KtKKYM/. Acesso em: 24.out.2025.
PUTRI, N. I. et al. Functionalization of pectin-depleted residue from different citrus by-products by high pressure homogenization. Food Hydrocoll, 129, p. 107638-107647, 2022. Disponível em: https://www.sciencedirect.com/science/article/pii/S0268005X22001588. Acesso em: 24.out.2025.
RAKOCZY, K. et al. Applications of Limonene in Neoplasms and Non-Neoplastic Diseases. Int J Mol Sci, 26, p. 6539, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/40650139/. Acesso em: 24.out.2025.
RUIZ-PÉREZ, N. J. et al. Antimycotic Activity and Genotoxic Evaluation of Citrus sinensis and Citrus latifolia Essential Oils. Sci Rep, 6, p. 25371-25379, 2016. Disponível em: https://doi.org/10.1038/srep25371. Acesso em: 24.out.2025.
RUVIARO, C. F. et al. Food losses and wastes in brazil: a systematic review. RDSD, 6, p. 78-90, 2020. Disponível em: https://periodicos.unesc.net/ojs/index.php/RDSD/article/view/5878. Acesso em: 24.out.2025.
SEBRAE. Cresça com os cosméticos orgânicos. Mercado e vendas | análise de tendência. 2023. Disponível em: https://sebrae.com.br/sites/PortalSebrae/artigos/cresca-com-os-cosmeticos-organicos,48425cc1c52a6810VgnVCM1000001b00320aRCRD. Acesso em: 24.out.2025.
SHARMA, K. et al. Converting citrus wastes into value-added products: Economic and environmently friendly approaches. Nutrition, 34, p. 29-46, 2017. Disponível em: https://www.sciencedirect.com/science/article/pii/S0899900716302131. Acesso em: 24.out.2025.
TISCINI, R.; MARTINIELLO, L.; LOMBARDI, R. Circular economy and environmental disclosure in sustainability reports: Empirical evidence in cosmetic companies. Bus Strateg Environ, 31, p. 892-907, 2022. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/bse.2924. Acesso em: 24.out.2025.
TOSCANO-GARIBAY, J. D. et al. Antimutagenic and antioxidant activity of the essential oils of Citrus sinensis and Citrus latifolia. Sci Rep 7, p. 11479-11487, 2017. Disponível em: https://doi.org/10.1038/s41598-017-11818-5. Acesso em: 24.out.2025.
TUNDIS, R. et al. Health-Promoting Properties and Potential Application in the Food Industry of Citrus medica L. and Citrus × clementina Hort. Ex Tan. Essential Oils and Their Main Constituents. Plants (Basel), 12, p. 991, 2023. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36903853/. Acesso em: 24.out.2025.
VALGIMIGLI, L. et al. Lemon (Citrus limon, Burm.f.) essential oil enhances the trans-epidermal release of lipid-(A, E) and water-(B6, C) soluble vitamins from topical emulsions in reconstructed human epidermis. Int J Cosmet Sci, p. 347-356, 2012. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/j.1468-2494.2012.00725.x. Acesso em: 24.out.2025.
ŻYNDA, W.; RUCZAJ, A.; GALICKA, A. Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action. Antioxidants (Basel), 14, p. 389, 2025. Disponível em: https://pubmed.ncbi.nlm.nih.gov/40298643/. Acesso em: 24.out.2025.
