Síndrome de DRESS: estudo de caso
DOI:
https://doi.org/10.34119/bjhrv9n1-138Keywords:
síndrome de DRESS, lamotrigina, hepatite medicamentosa, eosinofilia, reação adversa a medicamentosAbstract
A síndrome de DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) é uma reação adversa medicamentosa rara e potencialmente fatal, caracterizada por exantema cutâneo, eosinofilia e envolvimento sistê/mico. Relata-se o caso de uma paciente do sexo feminino, previamente hígida, em uso de lamotrigina para tratamento de transtorno afetivo bipolar, que apresentou icterícia, prurido, febre e rash cutâneo duas semanas após aumento da dose do fármaco. Os exames laboratoriais mostraram elevação acentuada de transaminases e eosinofilia periférica, com sorologias virais negativas. Diante do quadro clínico e da cronologia dos sintomas, foi estabelecido o diagnóstico de síndrome de DRESS induzida por lamotrigina, confirmado pelo escore RegiSCAR. A paciente foi transferida para hospital de referência devido ao risco de insuficiência hepática aguda, onde recebeu corticoterapia sistêmica, evoluindo com melhora progressiva sem necessidade de transplante hepático. Esse caso ilustra a importância do reconhecimento precoce e da suspensão imediata da droga suspeita, medidas fundamentais para o desfecho favorável. O reconhecimento e manejo precoce da Síndrome de DRESS são fundamentais para reduzir a morbimortalidade associada e otimizar o uso racional de medicamentos na rede pública de saúde, reforçando a importância da vigilância farmacológica e da capacitação das equipes no âmbito do Sistema Único de Saúde.
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