Relação entre resistência à insulina e declínio cognitivo em adultos com síndrome metabólica: uma revisão narrativa
DOI:
https://doi.org/10.34119/bjhrv9n1-109Keywords:
síndrome metabólica, cognição, comprometimento cognitivo, demência, fatores de risco, envelhecimentoAbstract
A síndrome metabólica (SM) tem sido associada ao comprometimento cognitivo em diferentes populações e fases do ciclo de vida. Esta revisão narrativa teve como objetivo analisar a literatura recente sobre a relação entre SM e desempenho cognitivo, considerando estudos publicados entre 2017 e 2025. Foi realizada uma busca na base de dados PubMed, sem restrição quanto ao tipo de estudo, utilizando descritores específicos e aplicando critérios de inclusão e exclusão definidos previamente. Dezessete estudos foram selecionados e analisados quanto aos seus métodos, populações, domínios cognitivos avaliados e principais achados. Os resultados indicaram associação consistente entre SM e déficits em funções executivas, memória e velocidade de processamento. Componentes isolados da SM, como hiperglicemia e obesidade central, também apresentaram correlação negativa com o desempenho cognitivo. As evidências sugerem que a SM é um fator de risco modificável para o declínio cognitivo, com implicações clínicas relevantes para a prevenção de demência e comprometimento neurocognitivo. São necessárias pesquisas futuras que explorem mecanismos causais e intervenções terapêuticas.
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