Efeitos da administração de opioides do grupo das fenilpiperidinas em equinos: revisão de literatura
DOI:
https://doi.org/10.34119/bjhrv9n1-086Keywords:
analgésico, anestesia equina, controle da dor, fentanil, opioide μ-agonistaAbstract
Opioides são analgésicos potentes, contudo seu uso em equinos é cauteloso devido aos efeitos adversos já relatados na espécie. Dessa forma, objetivou-se realizar uma revisão sistemática acerca do uso de opioides do grupo das fenilpiperidinas em equinos, bem como seus efeitos farmacológicos e adversos, vias de administração e indicações clinicocirúrgicas ou experimentais. O presente estudo foi realizado através da busca por trabalhos científicos, utilizando os indexadores “fentanyl in horses”, “alfentanil in horses“, “remifentanil in horses” e “sufentanil in horses”, combinados ou não. A partir da pesquisa, foram selecionadas 26 publicações a respeito do tema, em que o conteúdo na íntegra se relacionava com o objeto de estudo. Conclui-se que os fármacos estudados produzem analgesia de curta duração, reduzem discretamente o requerimento anestésico, podem ser administrados por diferentes vias parenterais e promovem efeitos adversos mínimos e dose-dependentes em equinos.
References
BENMANSOUR, P. et al. Blood concentrations of remifentanil during and after infusion in horses anesthetized with isoflurane and dexmedetomidine. Research in Veterinary Science, v. 107, p. 202- 206, 2016.
BENMANSOUR, P.; DUKE–NOVAKOVSKI, T. Prolonged anesthesia using sevoflurane, remifentanil and dexmedetomidine in a horse. Veterinary Anaesthesia and Analgesia, v. 40, n. 5, p. 521-526, 2013.
BENMANSOUR, P. et al. Cardiopulmonary effects of an infusion of remifentanil or morphine in horses anesthetized with isoflurane and dexmedetomidine. Veterinary Anaesthesia and Analgesia, v. 41, n. 4, p. 346-356, 2014.
DMITROVIĆ, P. et al. Effect of fentanyl infusion on heart rate variability and anaesthetic requirements in isoflurane-anaesthetized horses. Animals, v. 11, n. 10, p. 1-11, 2021.
DUARTE, D. F. Uma breve história do ópio e dos opióides. Revista Brasileira de Anestesiologia, v. 55, n. 1, p. 135-146, 2005.
EBERSPÄCHER, E. et al. Pharmacokinetics and tolerance of transdermal fentanyl administration in foals. Veterinary Anaesthesia and Analgesia, v. 35, n. 3, p. 249-255, 2008.
ECHELMEYER, J. et al. Effect of fentanyl on thermal and mechanical nociceptive thresholds in horses and estimation of anti-nociceptive plasma concentration. The Veterinary Journal, v. 249, p. 82-88, 2019.
FUJIYAMA, M.; JONES, T.; DUKE-NOVAKOVSKI, T. Evaluation of the perioperative stress response from dexmedetomidine infusion alone, with butorphanol bolus or remifentanil infusion compared with ketamine and morphine infusions in isoflurane-anesthetized horses. Veterinary Anaesthesia and Analgesia, v. 48, n. 3, p. 344-355, 2021.
GANIDAGLI, S. et al. Comparison of ropivacaine with a combination of ropivacaine and fentanyl for the caudal epidural anaesthesia of mares. Veterinary Record, v. 154, n. 11, p. 329-332, 2004.
KNYCH, H. K. et al. Disposition, behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals. Equine Veterinary Journal, v. 47, n. 5, p. 592- 598, 2015a.
KNYCH, H. K. et al. Effects of age on the pharmacokinetics and selected pharmacodynamics of intravenously administered fentanyl in foals. Equine Veterinary Journal, v. 47, n. 1, p. 72-77, 2015b.
KNYCH, H. K. D. et al. Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. American Journal of Veterinary Research, v. 70, n. 10, p. 1193-1200, 2009.
JONES, T. et al. Total intravenous anesthesia with alfaxalone, dexmedetomidine and remifentanil in healthy foals undergoing abdominal surgery. Veterinary Anaesthesia and Analgesia, v. 46, p. 315- 324, 2019.
MIZOBE, F. et al. Clinical usefulness of intravenous constant rate infusion of fentanyl and medetomidine under sevoflurane anesthesia in Thoroughbred racehorses undergoing internal fixation surgery. Journal of Equine Science, v. 28, n. 4, p. 143-147, 2017.
NATALINI, C. C.; ROBINSON, E. P. Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. American Journal of Veterinary Research, v. 61, n. 12, p. 1579-1586, 2000.
OHTA, M. et al. Effects of intravenous fentanyl administration on end-tidal sevoflurane concentrations in Thoroughbred racehorses undergoing orthopedic surgery. Journal of Veterinary Medical Science, v. 72, n. 9, p. 1107-1111, 2010.
PALLAROLS, N. B. et al. Behavioral and cardiopulmonary effects of a constant rate infusion of remifentanil–xylazine for sedation in horses. Journal of Equine Veterinary Science, v. 91, p. 1-6, 2020.
QUEIROZ-NETO, A. et al. Behavioral and antinociceptive effects of alfentanil, butorphanol, and flunixin in horses. Journal of Equine Veterinary Science, v. 33, n. 12, p. 1095-1100, 2013.
REED, R. A. et al. The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses. Frontiers in Pain Research, v. 5, p. 1-9, 2024.
SANCHEZ, L. C. et al. Effect of fentanyl on visceral and somatic nociception in conscious horses. Journal of Veterinary Internal Medicine, v. 21, n. 5, p. 1067-1075, 2007.
SKRZYPCZAK, H. et al. The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses. Equine Veterinary Journal, v. 54, n. 1, p. 1-6, 2021.
SIQUEIRA, V. J. et al. Utilização da mistura sufentanil e cloridrato de xilazina 10% para neuroleptoanalgesia a campo em equinos. Veterinária Notícias, v. 15, n. 1, p. 69-74, 2009.
THOMASY, S. M. et al. The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses. British Journal of Anaesthesia, v. 97, n. 2, p. 232-237, 2006.
THOMASY, S. M. et al. Transdermal fentanyl combined with nonsteroidal anti‐inflammatory drugs for analgesia in horses. Journal of Veterinary Internal Medicine, v. 18, n. 4, p. 550-554, 2004.
VAN DIJK, P.; NYKS, S. K. Changes in heart rate, mean arterial pressure, blood biochemistry, plasma glucose, plasma lactate and some plasma enzymes during sufentanil/halothane anaesthesia in horses. Journal of Veterinary Anaesthesia, v. 25, n. 1, p. 13-18, 1998.
WETMORE, L. A. et al. Effects of fentanyl administration on locomotor response in horses with the G57C µ-opioid receptor polymorphism. American Journal of Veterinary Research, v. 77, n. 8, p. 828-832, 2016.
