Case report: IgG4-related disease with isolated testicular involvement
DOI:
https://doi.org/10.34119/bjhrv8n6-324Keywords:
IgG4, testicle, organomegalyAbstract
IgG4 immunoglobulin-related disease is a recently described clinical entity, recognized as a systemic disease in 2003 in the work of Kamisawa et al, describing an autoimmune pancreatitis with extrapancreatic manifestations. It is prevalent in men over 50 years of age, with a male to female ratio of 2.8:1. This case report presents a 32-year-old man with a tumor mass in his testicle, with no other systemic manifestations of the disease.
References
Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, Okamoto A, Egawa N, Nakajima H. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38(10):982-4. doi: 10.1007/s00535-003-1175-y. PMID: 14614606.
Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Kubota K, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, Stone JR, Takahashi N, Umehara H, Webster G, Zen Y, Stone JH; American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis Rheumatol. 2020 Jan;72(1):7-19. doi: 10.1002/art.41120. Epub 2019 Dec 2. PMID: 31793250.
Maritati F, Peyronel F, Vaglio A. IgG4-related disease: a clinical perspective. Rheumatology (Oxford). 2020 May 1;59(Suppl 3):iii123-iii131. doi: 10.1093/rheumatology/kez667. PMID: 32348524.
Katz G, Stone JH. Clinical Perspectives on IgG4-Related Disease and Its Classification. Annu Rev Med. 2022 Jan 27;73:545-562. doi: 10.1146/annurev-med-050219-034449. Epub 2021 Oct 20. PMID: 34669430.
Lanzillotta M, Mancuso G, Della-Torre E. Advances in the diagnosis and management of IgG4 related disease. BMJ. 2020 Jun 16;369:m1067. doi: 10.1136/bmj.m1067. PMID: 32546500.
Shams A, DAS A, Sinha M, Gulati N, Mehndiratta MM, Kaushik M, Gupta P. IgG4-Related Disease with Selective Testicular Involvement- A Rare Entity: Case Report with Review of Literature. Turk Patoloji Derg. 2021;37(1):78-83. doi: 10.5146/tjpath.2020.01493. PMID: 32525212; PMCID: PMC10508931.
Soputro NA, Kapoor J, Popa I, Katz D. Testicular-sparing excision for benign paratesticular IgG4-related disease. BMJ Case Rep. 2021 Sep 7;14(9):e243450. doi: 10.1136/bcr-2021-243450. PMID: 34493553; PMCID: PMC8424693.
Carrillo-Córdova LD, Carrillo-Córdova CA, Vitar-Sandoval J, Jaspersen-Álvarez J, Villena-López EL, Carrillo-Esper R. Manifestaciones urológicas de la enfermedad relacionada con la inmunoglobulina G4 [Urological manifestations of the disease related to immunoglobulin G4]. Cir Cir. 2018;86(1):63-70. Spanish. doi: 10.24875/CIRU.M18000004. PMID: 29681634.
Gonzalez CA, Carrillo Linares JL, García Muñoz I, Escalona García A, Valdivielso P. IgG4-Related Disease Affecting Testicle and Myelodysplastic Syndrome: Just a Coincidence? Eur J Case Rep Intern Med. 2021 Dec 28;8(12):002981. doi: 10.12890/2021_002981. PMID: 35059333; PMCID: PMC8765686.
Wang G, Zhuo N, Luo X, Tian F, Wen Z, Li J. IgG4-Related Disease With Testicular Involvement: A Case Report and Review of Literature. Front Immunol. 2021 Aug 10;12:717902. doi: 10.3389/fimmu.2021.717902. PMID: 34447384; PMCID: PMC8383176.
Wang G, Zhuo N, Luo X, Tian F, Wen Z, Li J. IgG4-Related Disease With Testicular Involvement: A Case Report and Review of Literature. Front Immunol. 2021 Aug 10;12:717902. doi: 10.3389/fimmu.2021.717902. PMID: 34447384; PMCID: PMC8383176.
Kim KH, Sung DJ, Han NY, Park BJ, Kim MJ, Cho SB, Kim JJ. Immunoglobulin G4-related paratesticular fibrous pseudotumor and retroperitoneal fibrosis: a case report. Urol Int. 2015;94(3):369-72. doi: 10.1159/000362215. Epub 2014 Aug 16. PMID: 25138678.
Crestani A, Vassallo L, Amodeo A, Diminutto A, Miglioranza E, Di Gianfrancesco L, Corsi P, Porreca A, Scapinello A. Paratesticular fibrous pseudotumor with histological features of IgG4-related disease: two case reports and review of the literature. Gland Surg. 2023 Mar 31;12(3):426-431. doi: 10.21037/gs-22-290. Epub 2023 Mar 3. PMID: 37057041; PMCID: PMC10086777.
Karram S, Kao CS, Osunkoya AO, Ulbright TM, Epstein JI. Idiopathic granulomatous orchitis: morphology and evaluation of its relationship to IgG4 related disease. Hum Pathol. 2014 Apr;45(4):844-50. doi: 10.1016/j.humpath.2013.12.003. Epub 2013 Dec 21. PMID: 24656095.
de Buy Wenniger LM, Scheltema JM, Verheij J, Beuers U. Testicular inflammation as a new manifestation of IgG4-associated disease. Urology. 2013 Aug;82(2):e15-6. doi: 10.1016/j.urology.2013.04.046. PMID: 23896119.
Migita K, Miyashita T, Mizuno A, Jiuchi Y, Ito M, Matsuo M, Izumi Y, Takeoka A, Nishino A, Hayashi M. IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease. Mod Rheumatol. 2014 Jan;24(1):188-94. doi: 10.3109/14397595.2013.852841. PMID: 24261777.
Isobe T, Naiki T, Naiki-Ito A, Kawai T, Etani T, Nagai T, Nozaki S, Kobayakawa Y, Iwatsuki S, Matsuyama N, Kato H, Kawai N, Yasui T. Rare case of immunoglobulin G4-related disease arising in gonadal glands with long-term remission without steroid treatment: Discussion and literature review. IJU Case Rep. 2021 Mar 15;4(3):188-191. doi: 10.1002/iju5.12279. PMID: 33977256; PMCID: PMC8088880.
Lal J, Bhat S, Doddamani S, Devi L. Isolated testicular immunoglobulin G4-related disease: A mimicker of malignancy. Indian J Urol. 2016 Oct-Dec;32(4):326-328. doi: 10.4103/0970-1591.191273. PMID: 27843221; PMCID: PMC5054669.
