Reconhecimento precoce e manejo inicial do delirium hospitalar: estratégias práticas para diagnóstico rápido e conduta efetiva pela equipe médica
DOI:
https://doi.org/10.34119/bjhrv8n6-179Keywords:
delirium, diagnóstico precoce, unidade de terapia intensivaAbstract
Considerando que o delirium hospitalar é uma perturbação neuropsiquiátrica aguda, reversível e geralmente subdiagnosticada, especialmente em pacientes idosos e críticos, torna-se imprescindível entender as estratégias que favorecem seu reconhecimento e manejo precoce. Objetiva-se analisar e discutir as condutas mais resolutivas para o diagnóstico rápido e tratamento inicial do delirium, destacando o papel da equipe multiprofissional e a aplicação de protocolos baseados em evidências. Dessa forma, realizou-se uma revisão integrativa da literatura nas bases PubMed, Scopus, Embase, Web of Science e SciELO, abrangendo estudos publicados entre 2020 e 2025 sobre diagnóstico, prevenção e manejo clínico do delirium hospitalar. Desse modo, notou-se que o uso de instrumentos validados como o Confusion Assessment Method (CAM), o CAM-ICU e o 4AT, junto à implementação do protocolo ABCDEF e às medidas não farmacológicas, constitui a abordagem mais efetiva para reduzir complicações, tempo de internação e mortalidade. Conclui-se que o enfrentamento eficaz do delirium hospitalar requer educação contínua das equipes, padronização de protocolos e integração multiprofissional, promovendo maior segurança e qualidade assistencial.
References
ALATERRE, Camille et al. Monitoring delirium in the intensive care unit: Diagnostic accuracy of the CAM-ICU tool when performed by certified nursing assistants – A prospective multicenter study. Intensive & Critical Care Nursing, v. 79, p. 103487, 2023. DOI: https://doi.org/10.1016/j.iccn.2023.103487.
ALDWIKAT, Rami K. et al. Validation of two screening tools for detecting delirium in older patients in the post-anaesthetic care unit: A diagnostic test accuracy study. International Journal of Environmental Research and Public Health, v. 19, n. 23, p. 16020, 2022. DOI: https://doi.org/10.3390/ijerph192316020.
AMERICAN PSYCHIATRIC ASSOCIATION (APA). Diagnostic and Statistical Manual of Mental Disorders – DSM-5-TR. 5. ed. rev. Washington, DC: American Psychiatric Association, 2022.
BRIGANTI, Giovanni. Delirium in the elderly. Psychiatria Danubina, v. 37, supl. 1, p. 104–111, 2025.
CHANG, Yue et al. Diagnostic accuracy of the "4 A's Test" delirium screening tool for the postoperative cardiac surgery ward. The Journal of Thoracic and Cardiovascular Surgery, v. 165, n. 3, p. 1151–1160.e8, 2023. DOI: https://doi.org/10.1016/j.jtcvs.2021.05.031.
EGBERTS, Angelique et al. Anticholinergic drug burden and delirium: A systematic review. Journal of the American Medical Directors Association, v. 22, n. 1, p. 65–73.e4, 2021. DOI: https://doi.org/10.1016/j.jamda.2020.04.019.
GARNIER-CRUSSARD, Antoine et al. Diagnostic et prise en soins du syndrome confusionnel aigu chez la personne âgée [Diagnosis and management of delirium in older adults]. La Revue de Médecine Interne, v. 46, n. 5, p. 265–275, 2025. DOI: https://doi.org/10.1016/j.revmed.2024.11.005.
GOLDBERG, Terry E. et al. Association of delirium with long-term cognitive decline: A meta-analysis. JAMA Neurology, v. 77, n. 11, p. 1373–1381, 2020. DOI: https://doi.org/10.1001/jamaneurol.2020.2273.
HELFAND, Benjamin K. I. et al. Detecting delirium: A systematic review of identification instruments for non-ICU settings. Journal of the American Geriatrics Society, v. 69, n. 2, p. 547–555, 2021. DOI: https://doi.org/10.1111/jgs.16879.
HSHIEH, Tamara T.; INOUYE, Sharon K.; OH, E. S. Delirium in the elderly. Clinics in Geriatric Medicine, v. 36, n. 2, p. 183–199, 2020. DOI: https://doi.org/10.1016/j.cger.2019.11.001.
IGLSEDER, Bernhard; FRÜHWALD, Thomas; JAGSCH, Christoph. Delirium in geriatric patients. Wiener Medizinische Wochenschrift, v. 172, n. 5–6, p. 114–121, 2022. DOI: https://doi.org/10.1007/s10354-021-00904-z.
ISHII, Kenzo et al. Current status of delirium assessment tools in the intensive care unit: A prospective multicenter observational survey. Scientific Reports, v. 12, n. 1, p. 2185, 2022. DOI: https://doi.org/10.1038/s41598-022-06106-w.
JAQUA, Emily E.; NGUYEN, Van T. N.; CHIN, Eric. Delirium in older persons: Prevention, evaluation, and management. American Family Physician, v. 108, n. 3, p. 278–287, 2023. PMID: 37725462.
LINDROTH, Heidi et al. World delirium awareness and quality survey in 2023 – a worldwide point prevalence study. Age and Ageing, v. 53, n. 11, afae248, 2024. DOI: https://doi.org/10.1093/ageing/afae248.
LIU, Si Bo et al. Delirium in the ICU: How much do we know? A narrative review. Annals of Medicine, v. 56, n. 1, p. 2405072, 2024. DOI: https://doi.org/10.1080/07853890.2024.2405072.
MART, Matthew F. et al. Prevention and management of delirium in the intensive care unit. Seminars in Respiratory and Critical Care Medicine, v. 42, n. 1, p. 112–126, 2021. DOI: https://doi.org/10.1055/s-0040-1710572.
MIRANDA, Fabián et al. Confusion assessment method for the intensive care unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings. The Cochrane Database of Systematic Reviews, v. 11, CD013126, 2023. DOI: https://doi.org/10.1002/14651858.CD013126.pub2.
MORAES, Fábio da Silva et al. ABCDE and ABCDEF care bundles: A systematic review of the implementation process in intensive care units. Medicine, v. 101, n. 25, e29499, 2022. DOI: https://doi.org/10.1097/MD.0000000000029499.
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE. Delirium: prevention, diagnosis and management in hospital and long-term care. Clinical guideline CG103. London: NICE, jan. 2023. ISBN 978-1-4731-4953-3
OLDHAM, Matthew A.; WEBER, Margaret T. The phenotype of delirium based on a close reading of diagnostic criteria. International Journal of Geriatric Psychiatry, v. 38, n. 12, e6046, 2023. DOI: https://doi.org/10.1002/gps.6046.
ORMSETH, Cora H. et al. Predisposing and precipitating factors associated with delirium: A systematic review. JAMA Network Open, v. 6, n. 1, e2249950, 2023. DOI: https://doi.org/10.1001/jamanetworkopen.2022.49950.
PALAKSHAPPA, Jayasree A.; HOUGH, Catherine L. How we prevent and treat delirium in the ICU. Chest, v. 160, n. 4, p. 1326–1334, 2021. DOI: https://doi.org/10.1016/j.chest.2021.06.002.
PINHEIRO, Fernanda Gomes de Magalhães Soares et al. Prevalência e fatores de risco associados ao delirium em uma unidade de terapia intensiva. Acta Paulista de Enfermagem, v. 35, eAPE00646, ago. 2022.
POUW, Maaike A. et al. Diagnostic accuracy of the Dutch version of the 4AT for delirium detection in a mixed patient population and setting. Aging Clinical and Experimental Research, v. 35, n. 8, p. 1705–1710, 2023. DOI: https://doi.org/10.1007/s40520-023-02447-2.
PRENDERGAST, Nathan T.; TIBERIO, Peter J.; GIRARD, Timothy D. Treatment of delirium during critical illness. Annual Review of Medicine, v. 73, p. 407–421, 2022. DOI: https://doi.org/10.1146/annurev-med-042220-013015.
RANGAPPA, Rajavardhan. Delirium in ventilated patients: Is ABCDEF bundle the solution? Indian Journal of Critical Care Medicine, v. 25, n. 7, p. 743–744, 2021. DOI: https://doi.org/10.5005/jp-journals-10071-23903.
SADLONOVA, Monika et al. Pharmacologic treatment of delirium symptoms: A systematic review. General Hospital Psychiatry, v. 79, p. 60–75, 2022. DOI: https://doi.org/10.1016/j.genhosppsych.2022.10.010.
SMITH, Camryn J. et al. The pathophysiology and biomarkers of delirium. Seminars in Neurology, v. 44, n. 6, p. 720–731, 2024. DOI: https://doi.org/10.1055/s-0044-1791666.
SOSNOWSKI, Kellie et al. The effect of the ABCDE/ABCDEF bundle on delirium, functional outcomes, and quality of life in critically ill patients: A systematic review and meta-analysis. International Journal of Nursing Studies, v. 138, p. 104410, 2023. DOI: https://doi.org/10.1016/j.ijnurstu.2022.104410.
SOSNOWSKI, Kellie et al. Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: A study protocol for a randomised controlled trial with embedded process evaluation. BMJ Open, v. 11, n. 7, e044814, 2021. DOI: https://doi.org/10.1136/bmjopen-2020-044814.
STOLLINGS, Joanna L. et al. Delirium in critical illness: Clinical manifestations, outcomes, and management. Intensive Care Medicine, v. 47, n. 10, p. 1089–1103, 2021. DOI: https://doi.org/10.1007/s00134-021-06503-1.
STOLLINGS, Joanna L. et al. Antipsychotics and the QTc interval during delirium in the intensive care unit: A secondary analysis of a randomized clinical trial. JAMA Network Open, v. 7, n. 1, e2352034, 2024. DOI: https://doi.org/10.1001/jamanetworkopen.2023.52034.
SVENNINGSEN, Helle et al. Delirium screening instruments. Ugeskrift for Læger, v. 186, n. 8, V04230263, 2024. DOI: https://doi.org/10.61409/V04230263.
TIEGES, Zoë et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: Systematic review and meta-analysis. Age and Ageing, v. 50, n. 3, p. 733–743, 2021. DOI: https://doi.org/10.1093/ageing/afaa224.
WILSON, Jo Ellen et al. Delirium. Nature Reviews Disease Primers, v. 6, n. 1, p. 90, 2020. DOI: https://doi.org/10.1038/s41572-020-00223-4.


