Hospitalizations and deaths due to mycoses in the municipality of Recife (PE), Brazil: a ten-year retrospective analysis (2014-2024)
DOI:
https://doi.org/10.34119/bjhrv8n5-039Keywords:
epidemiology, fungal infection, mortality, datasus, underdiagnosisAbstract
Mycoses are highly prevalent in Brazil, and the city of Recife stands out for the growing number of fungal infections, especially among immunocompromised individuals or patients, significantly affecting quality of life. Furthermore, there is underdiagnosis due to a lack of resources and training among healthcare professionals. This study performs a retrospective analysis of the epidemiological profile of hospitalizations and deaths caused by mycoses in the population of Recife, Pernambuco, between 2014 and 2024. Using a descriptive and quantitative approach, data were collected from the Hospital Information System of the Unified Health System (DATASUS) from January 2014 to December 2024. For mycosis cases, the following variables were analyzed: number of hospitalizations, deaths, sex, race/ethnicity, and year. The results showed that during the analyzed period, Recife recorded 1,348 hospitalizations and 88 deaths due to mycoses. Most hospitalizations occurred in 2014 (12.1%). However, 2023 and 2024 had the lowest numbers of cases, 5.6% and 6.1%, respectively. The predominant age group was 40 to 49 years old. Deaths were more frequent in 2014 (21.6%) and concentrated in older age groups (50 to 79 years old). Hospitalizations and deaths occurred mainly in emergencies, and most cases involved individuals of mixed race and males. The data suggest that hospitalizations and deaths due to mycoses require more attention to reporting and indicate the need to develop strategies for more efficient diagnosis and treatment.
References
AGROSOAIE, Radu Andi; AZOICAI, Doina; MATEI, Mioara Calipsoana. Desafios nas infecções fúngicas invasivas possivelmente associadas aos cuidados de saúde. Revista Romena de Medicina Legal, v. 2, pág. 162-167, 2021.
ALMEIDA, Railane Letícia Gomes; MACHADO, Eleuza Rodrigues. Cryptococcus spp. em pacientes com HIV/SIDA: Revisão da Literatura. Ensaios e Ciência: Ciências Biológicas, Agrárias e da Saúde, v. 18, n. 1, p. 55-63, 2014.
BARCHIESI, Francesco et al. Epidemiologia, características clínicas e desfecho da candidemia em um centro de referência terciário na Itália de 2010 a 2014. Infection, v. 44, p. 205-213, 2016.
BOROUJENI, Zeinab Borjian et al. Distribuição de infecções fúngicas invasivas: epidemiologia molecular, etiologia, condições clínicas, diagnóstico e fatores de risco: uma experiência de 3 anos com 490 pacientes em terapia intensiva. Patogênese microbiana, v. 152, p. 104616, 2021.
BRASIL. Ministério da Saúde. Esporotricose humana passa a ser de notificação compulsória. Brasília: Ministério da Saúde, 2025. Disponível em: https://www.gov.br/saude/pt-br/assuntos/noticias/2025/janeiro/esporotricose-humana-passa-a-ser-de-notificacao-compulsoria. Acesso em: 24 abr. 2025.
COUTINHO, Ziadir Francisco et al. Paracoccidioidomycosis mortality in Brazil (1980-1995). Cadernos de Saúde Pública, v. 18, p. 1441-1454, 2002.
DA SILVA, L. B. et al. Cryptococcosis in HIV-AIDS patients from Southern Brazil: Still a major problem. Journal de Mycologie Médicale, v. 30, n. 4, p. 101044, 2020.
DE MATOS, Mariana Prates et al. Análises retrospectivas de mortalidade por micoses: artigo de revisão. Referências em Saúde do Centro Universitário Estácio de Goiás, v. 3, n. 01, p. 100-105, 2020.
DO CARMO, Fabíolla Nacimento et al. Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil. Brazilian Journal of Microbiology, v. 53, n. 3, p. 1321-1337, 2022.
DE GUSMÃO PERAZZONI, Alice Roberto et al. Criptococose como problema de saúde pública no Distrito Federal. Programa de Iniciação Científica-PIC/UniCEUB-Relatórios de Pesquisa, 2022.
DOS SANTOS, Mário Jeová et al. Retrospective analysis of opportunistic mycosis mortality: the epidemiological scenario between 2013 and 2023. Brazilian Journal of Health Review, v. 8, n. 3, p. e79522-e79522, 2025.
FRANÇA, Hélio Emmanuel Pinto et al. Situação epidemiológica da esporotricose humana no nordeste brasileiro. Revista Eletrônica da Estácio Recife, v. 8, n. 1, 2022.
GNAT, Sebastian et al. A global view on fungal infections in humans and animals: opportunistic infections and microsporidioses. Journal of Applied Microbiology, v. 131, n. 5, p. 2095-2113, 2021.
INÁCIO, Moisés Morais et al. Challenges in serologic diagnostics of neglected human systemic mycoses: An overview on characterization of new targets. Pathogens, v. 11, n. 5, p. 569, 2022.
LACAZ, C. da S. et al. Tratado de micologia médica. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 5, p. 297-298, 2002.
LAHIRI, Shayanki et al. Trends of CNS Cryptococcosis during pre-and post-HIV era: a 38 years’ retrospective cohort analysis from South India. Journal of Medical Mycology, v. 33, n. 2, p. 101358, 2023.
DE MACÊDO-SALES, Pãmella Antunes et al. Diagnóstico laboratorial da esporotricose felina em amostras coletadas no estado do Rio de Janeiro, Brasil: limitações da citopatologia por imprint. Revista Pan-Amazônica de Saúde, v. 9, n. 2, p. 7-7, 2018.
MCCARTY, Todd P.; WHITE, Cameron M.; PAPPAS, Peter G. Candidemia and invasive candidiasis. Infectious Disease Clinics, v. 35, n. 2, p. 389-413, 2021.
MIRANDA, Alice Vasconcelos et al. Mortalidade por criptococose no Brasil entre 2020 e 2023. Journal of Health & Biological Sciences, v. 12, n. 1, p. 1-4, 2024.
MOREIRA, Izabela de Mesquita Bárcia et al. Investigação da heterorresistência ao fluconazol em isolados clínicos e ambientais do complexo Cryptococcus neoformans e complexo Cryptococcus gattii no estado do Amazonas, Brasil. Medical Mycology , v. 60, n. 3, 2022.
OLIVEIRA, Ester Maria Sotero de. A atuação do gestor escolar frente à pandemia de COVID-19: uma análise a partir da Rede de Ensino Municipal de Recife. 2024. Dissertação (Mestrado em Educação Básica) – Universidade Federal de Pernambuco, Recife, 2024.
PEÇANHA, Paulo Mendes et al. Paracoccidioidomycosis: what we know and what is new in epidemiology, diagnosis, and treatment. Journal of fungi, v. 8, n. 10, p. 1098, 2022.
PEREIRA, P. A. et al. Superficial and cutaneous mycoses, epidemiology, virulence, susceptibility profile to antifungals and their infections: a literature review of the last twenty years. International Journal of Pharmaceutical and Biological Sciences, v. 11, n. 1, p. 176-187, 2021.
PRADO, Marli et al. Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006. Memórias do Instituto Oswaldo Cruz, v. 104, p. 513-521, 2009.
ROCHA, Ana Paula Santiago et al. Perfil epidemiológico das leveduroses sistêmicas em Unidades de Terapia Intensiva de hospitais públicos da cidade do Recife–PE, Brasil. Brazilian Journal of Health Review, v. 3, n. 6, p. 19098-19111, 2020.
ROY, Madhura et al. Recent drug development and treatments for fungal infections. Brazilian Journal of Microbiology, v. 54, n. 3, p. 1695-1716, 2023.
SANTOS, Lauana Aparecida et al. Virulence factors of Paracoccidioides brasiliensis as therapeutic targets: a review. Antonie Van Leeuwenhoek, v. 113, p. 593-604, 2020.
SILVA, Kassia Gabriela Vieira et al. Morfologia, epidemiologia e virulência de espécies do gênero Candida. Tópicos nas ciências da saúde, v. 7, p. 42, 2021.
SILVA, Marcos Jessé Abrahão et al. Ecoepidemiologia da paracoccidioidomicose: Uma revisão narrativa da literatura. Research, Society and Development, v. 10, n. 9, p. e31810918182-e31810918182, 2021.
SOARES, Emmanuel Alves. Mortalidade por criptococose no Brasil (2000 a 2012). 2015.
TABATABAEI, Fahimeh; MOHARAMZADEH, Keyvan; TAYEBI, Lobat. Three-dimensional in vitro oral mucosa models of fungal and bacterial infections. Tissue Engineering Part B: Reviews, v. 26, n. 5, p. 443-460, 2020.
TAK, Vibhor et al. The epidemiological profile of candidemia at an Indian trauma care center. Journal of laboratory physicians, v. 6, n. 02, p. 096-101, 2014.
TAKAHASHI, Jacqueline Aparecida. Progress in the Development of Fungal Metabolites as New Drugs for Human Mycoses. In: Fungi Bioactive Metabolites: Integration of Pharmaceutical Applications. Singapore: Springer Nature Singapore, 2024. p. 495-513.
VALE, Daniel Santiago et al. Paracoccidioidomicose afetando a mucosa bucal: relato de caso. Rev. cir. traumatol. buco-maxilo-fac, p. 22-25, 2022.
WOODS, Tina R.; WHITE, Jamie; KOUTLAS, Ioannis. Fungal lesions of the oral mucosa diagnosis and management. Oral and Maxillofacial Surgery Clinics, v. 35, n. 2, p. 271-281, 2023.
ZHANG, Yi; LI, Ruoyu; WANG, Xiaowen. Monogenetic causes of fungal disease: recent developments. Current Opinion in Microbiology, v. 58, p. 75-86, 2020.
ZEMINIAN DE OLIVEIRA, Luciana Bonome et al. Paracoccidioimycosis and white individuals: Susceptibility and biogeographic aspects in an important endemic area in Brazil. PLoS Neglected Tropical Diseases, v. 15, n. 2, p. e0009086, 2021.


