Regeneração óssea personalizada em defeitos craniomaxilofaciais: integração de células-tronco, biomateriais e bioimpressão 3D
DOI:
https://doi.org/10.34119/bjhrv8n4-377Keywords:
regeneração óssea, células-tronco, biomateriais, bioimpressão 3d, cirurgia craniomaxilofacialAbstract
A regeneração óssea personalizada em defeitos craniomaxilofaciais tem se consolidado como um dos maiores avanços da medicina regenerativa contemporânea. O presente artigo analisa criticamente a integração entre células-tronco, biomateriais e bioimpressão 3D, discutindo seus fundamentos biológicos, desafios translacionais e perspectivas clínicas. Evidencia-se que nenhum recurso isolado é capaz de responder de forma plena às demandas regenerativas. A síntese possível está na articulação interdisciplinar, que une vitalidade celular, suporte estrutural e personalização tecnológica. Embora resultados clínicos iniciais sejam promissores, persistem limitações relacionadas à vascularização, padronização e acessibilidade. Conclui-se que o futuro da reconstrução craniomaxilofacial depende de uma integração responsável, capaz de aliar inovação com segurança e equidade no acesso.
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