Effects of physical exercise in women undergoing neoadjuvant chemotherapy for breast cancer: a systematic review with GRADE recommendation
DOI:
https://doi.org/10.34119/bjhrv8n4-014Keywords:
exercise, tumour microenvironment, breast neoplasm, neoadjuvant therapyAbstract
Background: physical exercise (PE) during breast cancer (BC) neoadjuvant chemotherapy (NC) has potential benefits on tumour environment, tumour size, quality of life and even survival. Evidence on this topic is required. Purpose: to review the literature on effects of PE on women with BC undergoing NC. Data Sources: MEDLINE, VHL, CINAHL, CENTRAL, EMBASE, Scopus, and Web of Science databases, without restrictions on year of publication. Risk of bias was assessed using the Cochrane Risk of Bias Tool. The GRADE criteria were applied to determine the strength of evidence. Results: Among 240 identified studies, two fulfilled the criteria for quantitative analysis, including 30 women undergoing BC NC. The GRADE analysis showed low evidence for most variables due to small sample size. Participants performed moderate to high-intensity PE, functional training, and resistance exercises for upper and lower limbs under supervision, for 30 to 60 minutes, three times per week, for 12 weeks. PE positively affected the tumour environment associated with angiogenesis and immunity; it also improved cardiorespiratory function, and reduced BMI. The PE parameters did not comply with all FITT components recommended. The rate of adherence to PE was about 80.0%. No adverse effects were reported. Conclusion: The practice of PE by women with BC NC has a large potential of positive effects on the tumour environment and on cardiorespiratory function. The parameters of PE should be described in more detail, according to the FITT recommended by the American College of Sports Medicine (ACSM). Despite that, PE seems feasible and safe. Larger studies are encouraged.
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