Brucelose humana, riscos associados e métodos de controle: Revisão sistemática rápida

Authors

  • Lindsy Caroline dos Santos Lima
  • Valentina Marques Bezerra
  • Bianca Gianola Belline Silva

DOI:

https://doi.org/10.34119/bjhrv8n3-238

Keywords:

epidemiologia, EPI’s (Equipamento de Proteção Individual), saúde pública, zoonose

Abstract

A brucelose humana é uma doença zoonótica endêmica em diversos países, amplamente negligenciada apesar de estar relacionada com grandes prejuízos econômicos e de saúde pública. É uma doença de difícil diagnóstico e reconhecimento em humanos, que tende a se estabelecer principalmente em grupos que têm contato frequente com animais não vacinados. Além do contato com os animais, a brucelose também pode infectar humanos através do consumo ou manuseio de produtos como o leite e carne crus. Este estudo objetivou, através de uma revisão sistemática rápida, reunir informações sobre os principais fatores de risco para brucelose em humanos, diagnóstico e prevenção.

 

References

ACHARYA, D.; HWANG, S., D.; PARK, J., H. Seroreactivity and Risk Factors Associated with Human Brucellosis among Cattle Slaughterhouse Workers in South Korea. International Journal of Environmental Research and Public Health. Vol. 15, p. 2396, 2018.

AKHVLEDIANI, T.; CLARK, D., V.; CHUBABRIA, G.; ZENAISHVILI, O.; HEPBUM, M., J. The changing pattern of human brucellosis: clinical manifestations, epidemiology, and treatment outcomes over three decades in Georgia. Bio Med Central Infectious Diseases. Vol. 10, n. 346, 2010.

AL-TAWFIQ, J., A.; ABUKHAMSIN, A. A 24-year study of the epidemiology of human brucellosis in a health-care systemin Eastern Saudi Arabia. Journal of Infection and Public Health.Vol. 2, p. 81-85, 2009.

AMEGASHIE, E., A. Comparison of three diagnostic methods in detecting brucella infection among slaughterhouse workers at the Kumasi abattoir, Ghana. 2015. Thesis (Master of Philosophy in Clinical Microbiology) - Kwane Nkrumah University of Science and Technoly, Gana, 2015. Disponivel em: https://ir.knust.edu.gh/handle/123456789/8007. Acesso em: 24 abr 2025.

AMRO, A.; MANSOOR, B.; HAMARSHEH, O.; BANK, W. Recent trends in human brucellosis in the West Bank, Palestine. International Journal of Infectious Diseases. Vol. 106, p. 308 – 313, 2021.

ANGEL, M., O.; RISTOW, P.; KO, A., I.; DI–LORENZO, C. Serological trail of Brucella infection in an urban slum population in Brazil. The Journal of Infection in Developing Countries. Vol. 6, n. 09, p. 675–679, 2012.

AWORH, M., K.; OKOLOCHA, E.; KWAGA, J.; FASINA, F.; LAZARUS, D.; SULEMAN, I.; POGGENSEE, G.; NGUKU, P.; NSUBUGA, P. Human brucellosis: seroprevalence and associated exposure factors among abattoir workers in Abuja, Nigeria - 2011. Pan African Medical Journal.Vol.16, p. 103, 2013.

BARDENSTEIN, S.; GIBBS, R., E.; YAGEL, Y.; MOTRO, Y.; MORAN-GILAD, J. Brucellosis Outbreak Traced to Commercially Sold Camel Milk through Whole-Genome Sequencing, Israel. Emerging Infection Diseases. Vol. 27(6): p. 1728-1731, 2021.

BARDENSTEIN, S.; GRUPEL, D.; BLUM, S., E.; MOTRO, Y.; GILAD, J., M. Public and animal health risks associated with spillover of Brucella melitensis into dairy farms. Research Aaticle - Microbial Genomics. Vol. 06, Issue 04, p. 9, 2023.

BOSCHIROLI, M., L.; FOULONGNE, V.; O’CALLAGHAN, D. Brucellosis: a worldwide zoonosis. Current opinion in microbiology, v. 4, n. 1, p. 58-64, 2001.

BUGEZA, J., K.; ROESEL, K.; MUGIZI, D., R.; ALINAITWE, L.; KIVALI, V.; KANKYA, C.; MORIYON, I.; COOK, E., A., J. Sero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Uganda. Plos Neglected Tropical Diseases. Vol, 18(3): e0012046, 2024.

CARUGATI, M.; BIGGS, H., M.; MAZE, M., J., M.; STODDARD, R., A.; GOLDWASSER, S., C.; HERTZ, J., T.; HALLIDAY, J., E., B.; SAGANDA, W.; LWEZAULA, B., F.; KAZWALA, R., R.; CLEAVELAND, S.; MARO, V., P.; RUBACH, M., P.; CRUMP, J., A. Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007–2008 and 2012–2014. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol. 112, p.136-143, 2018.

CARVALHO, R., F., B.; SANTOS, H., P.; MATHIAS, L., A. Frequência de brucelose bovina em rebanhos leiteiros e em seres humanos na região central do estado do Maranhão, Brasil. Arquivos do Instituto Biológico. Vol. 83, e1042014, 2016.

CAVALCANTE, R., S., B. Ocorrência de Brucella abortus em trabalhadores de frigoríficos no município de São Luís. 2016. Monografia (Bacharelado em Medicina Veterinária) - Graduação em Medicina Veterinária - Universidade Estadual do Maranhão - UEMA, Maranhão, 2016. Disponivel em: https://repositorio.uema.br/handle/123456789/862. Acesso em: 24 abr. 2025.

CLOETE, A.; GERSTENBERG, C.; MAYET, N.; TEMPIA, S. Brucellosis knowledge, attitudes and practices of a South African communal cattle keeper group. Onderstepoort Journal of Veterinary Research. Vol. 86, n. 1, 2019.

DÍEZ, J., G.; COELHO, A., C. An evaluation of cattle farmers’ knowledge of bovine brucellosis in northeast Portugal. Journal of Infection and Public Health. Vol. 6, p. 363-369, 2013.

FERNANDES, J., S.; SOARES, L., G.; MORAES, D., N.; AMORIM, C., G.; FERREIRA, C., L., E.; KIEL, F., P., H., M.; VICTÓRIA, C.; LANGONI, H. Zoonoses em animais de produção: aspectos gerais. Veterinária e Zootecnia, Botucatu, v. 23, n. 1, p. 49–71, 2016.

FERNANDES, A., E. Ocorrência de Brucella abortus em trabalhadores de frigoríficos no Estado do Maranhão. 2018. Dissertação (Mestrado em Defesa Sanidade Animal) - Universidade Estadual do Maranhão – UEMA, Maranhão, 2018. Disponivel em: https://repositorio.uema.br/handle/123456789/556. Acesso em: 24 abr. 2025.

GETAHUN, T., K.; URGE, B.; MAMO, G. Seroprevalence of human brucellosis in selected sites of Central Oromia, Ethiopia. Plos One. Vol. 17(12): e0269929, 2022.

GUAN, P.; WU, W.; HUANG, D. Trends of reported human brucellosis cases in mainland China from 2007 to 2017: an exponential smoothing time series analysis. Environ Health Preventive Medicine. Vol. 23, n. 23, 2018.

HAVAS, K., A.; RAMISHVILI, M.; NAVDARASHVILI, A.; HILL, A., E.; TSANAVA, S.; IMNADZE, P.; SALMAN, M., D. Risk factors associated with human brucellosis in the country of Georgia: a case-control study. Epidemiology and Infection. Vol. 141, p. 45–53, 2012.

HIGGINS, J., P., T.; THOMAS, J.; CHANDLER, J.; CUMPSTON, M.; LI, T.; PAGE, M., J.; WELCH, V., A. (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024), Cochrane, 2024.

HOLT, H., R.; BEDI, J., S.; KAUR, P.; MANGTANI, P.; SHARMA, N., S.; GILL, J., P., S.; SINGH, Y.; KUMAR, R.; KAUR, M.; MCGIVEN, J.; GUITIAN, J. Epidemiology of brucellosis in cattle and dairy farmers of rural Ludhiana, Punjab. Plos Neglected Tropical Diseases. Vol. 15(3): e0009102, 2021.

IARIA, C.; RICCIARDI, F.; MARANO, F.; PUGLISI, G.; PAPPAS, G.; CASCIO, A. Live Nativity and Brucellosis, Sicily. Emerging Infectious Diseases. Vol. 12, n. 12, 2006.

IGAWE, P., B.; OKOLOCHA, E.; KIA, G., S.; IRMIYA, I., B.; BALOGUN, M., S.; NGUKU, P. Seroprevalence of brucellosis and associated risk factors among abattoir workers in Bauchi State, Nigeria. Pan African Medical Journal. Vol, 35, n. 33, 2020.

JOHN, K.; FITZPATRICK, J.; FRENCH, N.; KAZWALA, R.; KAMBARGE, D.; GODFREY, S.; MFINANGA, G., S.; MAMILLAN, S.; CLEAELAND, S. Quantifying Risk Factors for Human Brucellosis in Rural Northern Tanzania. Plos One. Vol. 5(4): e9968, 2010.

KANSIIME, C.; MUGISHA, A.; MAKUMBI, F.; MUGISHA, S.; RWEGO, I., B.; SEMPA, J.; KIWANUKA, S., N.; ASIIMWE, B., B.; RUTEBEMBERWA, E. Knowledge and perceptions of brucellosis in the pastoral communities adjacent to Lake. Mburo National Park, Uganda. Bio Med Central Public Health. Vol. 14, p. 242, 2014.

KIAMBI, S., G.; FÈVRE, E., M.; OMOLO, J.; OUNDO, J., G. Risk factors for acute human brucellosis in Ijara, north-eastern Kenya. Plos Neglected Tropical Diseases. Vol. 14(4): e0008108, 2020.

KUNDA, J.; FITZPATRICK, J.; KAZWALA, R.; FRENCH, N., P.; SHIRIMA, G.; MACMILLAN, A.; KAMBARAGE, D.; BRONAVOORT, M.; CLEAVELAND, S. Health-seeking behaviour of human brucellosis cases in rural Tanzania. Bio Med Central - Public Health. Vol. 7, p. 315, 2007.

LAWINSKY, L., J.; OHARA, M.; ELKHOURY, R.; FARIA, C.; CAVALCANTE, R., L., J. Estado da arte da brucelose em humanos. Revista Pan-Amazônica de Saúde. Vol. 1, n. 4, p. 10, 2010.

LEMOS, T., S.; CEQUINEL, J., C.; COSTA, T., P.; NAVARRO, A., B.; SPRADA, A.; SHIBATA, F., K.; GONDOLFO, R.; TUON, F., F. Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018. Plos One - Neglected Tropical Diseases. Vol. 12(9): e0006770, 2018.

LI, D.; LI, L.; ZHAI, J.; WANG, L.; ZHANG, B. Epidemiological features of human brucellosis in Tongliao City, Inner Mongolia province, China: a cross-sectional study over an 11-year period (2007–2017). BMJ Open. Vol. 10: e031206, 2019.

LI, Y., J.; LI, X., L.; LIANG, S.; FANG, L., Q.; CAO, W., C. Epidemiological features and risk factors associated with the spatial and temporal distribution of human brucellosis in China. Bio Med Central Infection Diseases. Vol. 13, p. 547, 2013.

LINDAHL, E.; SATTROV, N.; BOQVIST, S.; MAGNUSSON, U. A Study of Knowledge, Attitudes and Practices Relating to Brucellosis among Small-Scale Dairy Farmers in an Urban and Peri-Urban Area of Tajikistan. Plos One. Vol. 10(2): e0117318, 2015.

LIU, S.; SOONTORNCHAI, S.; BOVORNKITTI, S.; WANG, X. Epidemiological characteristics and spatio-temporal clusters of human brucellosis in Inner Mongolia, 2010–2021. Bio Med Central Infectious Diseases. Vol. 24, p. 1321, 2024.

MADUT, N., A.; OCAN, M.; MUWONGE, A.; MUMA, J., B.; NASINYAMA, G., W.; GODFROID, J.; JUBARA, A., S.; KANKYA, C. Sero-prevalence of brucellosis among slaughterhouse workers in Bahr el Ghazal region, South Sudan. Bio Med Central Infectious Diseases. Vol. 19, p, 450, 2019.

MADUT, N., A.; NASINYAMA, G., W.; MUMA, J., B.; SUBE, K., L., L.; OCAN, M., MUWONGE, A.; GODFROID, J.; JUBARA, A., S., J.; KANKYA, C. Prevalence of brucellosis among patients attending Wau Hospital, South Sudan. Plos One. Vol. 13(6): e0199315, 2018.

MADZINGIRA, O.; BYARUHANGA, C.; FASINA, F., O.; HEERDEN, H. Assessment of knowledge, attitudes and practices relating to brucellosis among cattle farmers, meat handlers and medical professionals in Namibia. Original Article – Wiley, Veterinary Medicine and Science. Vol. 9, p. 535-547, 2022.

MAKITA, K.; FÈRE, E., M.; WAISWA, C.; EISLER, M., C.; WELBUM, S., C. How Human Brucellosis Incidence in Urban Kampala Can Be Reduced Most Efficiently? A Stochastic Risk Assessment of Informally-Marketed Milk. Plos One. Vol. 5(12): e14188, 2010.

MBURU, C., M.; BUKACHI, S., A., H.; TOKPA, K.; FOKOU, G.; SHILABUKHA, K.; EZAKIEL, M.; BONFOH, B.; KAZWALA, R.; KREPPEL, K. Lay attitudes and misconceptions and their implications for the control of brucellosis in an agro-pastoral community in Kilombero district, Tanzania. Plos Neglected Tropical Diseases. Vol. 15(6): e0009500, 2021.

MEGID, J.; MATHIAS, L., A.; ROBLES, C., A. Clinical manifestations of brucellosis in domestic animals and humans. The Open Veterinary Science Journal, v.4, p. 119-126, 2010.

MIONI, M., S., R.; VICENTE, A, F.; PERES, M., G.; APPOLINÁRIO, C., M.; RIBEIRO, B., L., D.; PANTOJA, J., C., F.; ALMEIDA, J., P.; PINTO, N.; MATHIAS, L., A.; MEGID, J. Brucellosis Prevalence in Brazilian Slaughterhouses with Different Meat Inspection Systems. Journal of Food Protection. Vol 81, Issue 7, p. 1073-1079, 2018.

MONTASERI, Z.; MOHEBI, Z.; MASOUMI, R.; DEHGHAN, A.; BIJANI, M. A study of rural populations’ knowledge, attitude, and practice about brucellosis: a descriptive, cross-sectional, multicenter study. Bio Med Central Resarch Notes. Vol. 17, n. 34, 2024.

MUNYUA, P.; OSORO, E.; HUNSERGER, E.; NGERE, I.; MUTURI, M.; MWATONDO, A.; MARWANGA, D.; NGERE, P.; TILLER, R.; ONYANGO, C., O.; NJENGA, K.; WIDDOWSON, M., A. High incidence of human brucellosis in a rural Pastoralist community in Kenya, 2015. Plos Neglected Tropical Diseases. Vol. 15(2): e0009049, 2021.

MUSALLAM, I., I.; ABO-SHEHADA, M., N.; GUITIAN, J. Knowledge, Attitudes, and Practices Associated with Brucellosis in Livestock Owners in Jordan. The American Society of Tropical Medicine and Hygiene. Vol. 93(6), p. 1148-1155, 2015.

NASINYAMA, G.; SSEKAWOJWA, E.; OPUDA, J.; GRIMAUD, P.; ETTER, E.; BELLINGUEZ, A. Brucella sero-prevalence and modifiable risk factors among predisposed cattle keepers and consumers of un-pasteurized milk in Mbarara and Kampala districts, Uganda. African Health Sciences. Vol. 14, n. 4, 2014.

NING, P.; GUO, M.; GUO, K.; XU, L.; REN, M.; CHENG, Y.; ZHANG, Y. Identification and Effect Decomposition of Risk Factors for Brucella Contamination of Raw Whole Milk in China. Plos One. Vol. 8(7): e68230, 2013.

PAGE, M., J.; MCKENZIE, J., E.; BOSSUYT, P., M.; BOUTRON, I.; HOFFMANN, T., C.; MULROW, C., D.; SHAMSEER, L.; TETZLAFF, J., M.; AKL, E., A.; BRENNAN, S., E.; CHOU, R.; GLANVILLE, J.; GRIMSHAW, J., M.; HRÓBJARTSSON, A.; LALU, M., M.; LI, T.; LODER, E., W.; MAYO-WILSON, E.; MCDONALD, S.; MCGUINNESS, L., A.; MOHER, D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, n. 71, 2021.

RESENDE, I., V.; SILVA, M., F., S.; CARDOZO, S., P. Brucelose como uma doença transmitida por alimentos tendo o leite como principal veiculador/ Brucellosis as a disease transmitted by food with milk as the main carrier. Brazilian Journal of Development. Vol. 6, n. 10, p. 80818–80824, 2020.

RIBEIRO, A., C., A.; ARAÚJO, R., V.; ROSA, A., S., M.; SILVA, P., N.; MORAES, S., C.; KATAGIRI, S. Zoonoses e Educação em Saúde: Conhecer, Compartilhar e Multiplicar / Zoonoses and Health Education: Know, Share and Multiply. Brazilian Journal of Health Review. Vol. 3, n. 5, p. 12785–12801, 2020.

SHANTA, I., S.; HEFFELFINGER, J., D.; HOSSAIN, K.; AHMED, F., KAFI, M., A., H.; SULTANA, S.; TILLER, R.; KENNEDY, E., D.; KADZIK, M.; IVEY, M., I.; ISLAM, A.; AHMED, S., S., U.; RAHMAN, A., K., M., A.; GIASUDDIN, M.; NEGRON, M., E.; SALZER, J., S. Exposure to Brucella spp. in Humans and Cows in a High Milk-Producing Area of Bangladesh. EcoHealth. Vol. 20, p. 416–426, 2023.

SOFIAN, M.; AGHAKHANI, A.; VELAYATI, A., A.; BANIFAZL, M.; ESLAMIFAR, A.; RAMEZANI, A. Risk factors for human brucellosis in Iran: a case-control study. International Journal of Infectious Diseases. Vol. 12, p.157-161, 2008.

SUN, Z., X.; WANG, Y.; LI, Y., J.; YU, S., H.; WU, W.; HUANG, D., S.; GUAN, P. Socioeconomic, meteorological factors and spatiotemporal distribution of human brucellosis in China between 2004 and 2019—A study based on spatial panel model. Plos Neglected Tropical Diseases. Vol. 17(11): e0011765, 2023.

SYLLA, S.; SIDIMÉ, Y.; SUN, Y.; DOUMBOUYA, S.; CONG, Y. Seroprevalence investigation of bovine brucellosis in Macenta and Yomou, Guinea. Tropical Animal Health. Vol. 46, p. 1185–1191, 2014.

TSCHOPP, R.; GEBREGIORGIS, A.; TASSACHEW, Y.; ANDUALEM, H.; OSMAN, M.; WAQJIRA, M., W.; HATTENDORF, J.; MOHAMMED, A.; HAMID, M.; MOLLA, W.; MITIKU, S., A.; WALKE, H.; NEGRON, M.; KADZIK, M.; MAMO, G. Integrated human-animal sero-surveillance of Brucellosis in the pastoral Afar and Somali regions of Ethiopia. Plos Neglected Tropical Diseases. Vol. 15(8): e0009593, 2021.

TSEGAY, A.; TULI, G.; KASSA, T.; KEBEDE, N. Seroprevalence and risk factors of brucellosis in abattoir workers at Debre Zeit and Modjo export abattoir, Central Ethiopia. Bio Med Central Infectious Diseases. Vol. 17, n. 101, 2017.

TUMWINE, G.; MAATOVU, E.; KABASA, J., D.; OWINY, D., O.; MAJALIJA, S. Human brucellosis: sero-prevalence and associated risk factors in agro-pastoral communities of Kiboga District, Central Uganda. Bio Med Central Public Health. Vol. 15, p. 900, 2015.

VASCONCELLOS, S., A.; ITO, F., H. Principais zoonoses transmitidas pelo leite. Atualização. Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, v. 9, n. 1, p. 32-37, 2011.

ZANELLA, J., R., C. Zoonoses emergentes e reemergentes e sua importância para saúde e produção animal. Pesquisa Agropecuária Brasileira, v. 51, n. 5, p. 510–519, 2016.

ZHANG, D.; LV, D.; ZHENG, X.; DUAN, R.; QIN, S.; LU, X.; NIE, L.; ZHANG, P.; HAN, H.; DUAN, Q.; LIANG, J.; XIAO, M.; JING, H.; WANG, X. Case Report: Screening and Analysis for Brucellosis in Akesai Kazak Autonomous County, China. The American Journal of Tropical Medicine and Hygiene. Vol. 108(6), p. 1201-1203, 2023.

ZHANG, M.; CHEN, X.; BU, Q.; TAN, B.; YANG, T.; QING, L.; WANG, Y.; DENG, D. Spatiotemporal dynamics and influencing factors of human brucellosis in Mainland China from 2005–2021. Bio Med Central Infectious Diseases. Vol. 24, n. 76, 2024.

ZHANG, N.; FANG, X., Y.; ZHOU, W., Z.; TAN, Z., M.; LIANG, S., Y.; WANG, X., C.; HU, J., L.; BAO, C., J.; LIU, W., L. Epidemiological characteristics and temporal-spatial clustering analysis on human brucellosis in Jiangsu Province, 2006–2021. Scientific Reports. Vol. 13, n. 20024, 2023.

Published

06/12/2025

How to Cite

LIMA, L. C. dos S.; BEZERRA, V. M.; SILVA, B. G. B. Brucelose humana, riscos associados e métodos de controle: Revisão sistemática rápida. Brazilian Journal of Health Review, [S. l.], v. 8, n. 3, p. e80358, 2025. DOI: 10.34119/bjhrv8n3-238. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/80358. Acesso em: 17 oct. 2026.

Issue

Section

Original Papers