Principais achados macroscópicos na Doença de Whipple: uma revisão sistemática da literatura
DOI:
https://doi.org/10.34119/bjhrv8n2-231Keywords:
doença de Whipple, Tropheryma whipplei, endoscopiaAbstract
Introdução: A doença de Whipple é causada pelo Tropheryma whipplei. Em sua forma clássica, apresenta-se com artralgia, perda de peso, diarreia crônica, dor abdominal e fadiga. Objetivos: Analisar os aspectos macroscópicos da DW na endoscopia digestiva alta e correlacionar dados da biópsia e macroscopia com o tratamento. Métodos: Essa revisão foi realizada nas bases de dados PubMed/MEDLINE, utilizando os descritores: Whipple disease AND Endoscopy. Obteve-se um total de 285 artigos. Após leitura dos títulos e resumos, foram excluídos os que não se adequaram ao tema e aos objetivos desta revisão, restando 59 artigos. Após leitura integral destes, foram selecionados 28 artigos. Resultados/Discussão: Houve predomínio do sexo masculino e o acometimento foi mais prevalente em indivíduos acima dos 40 anos. O achado macroscópico mais descrito foi a mucosa com padrão granular branco-amarelado sugestivo de hiperplasia linfóide. Em relação a biópsia, a descrição predominante foi de macrófagos espumosos, presente na lâmina própria PAS positivos. Os principais sintomas foram a perda de peso e diarreia. Houve grande variedade entre os tratamentos, sendo o mais descrito Ceftriaxona seguido de Sulfametoxazol-Trimetoprima para manutenção. Conclusão: A DW é rara e pouco descrita na literatura. Mais estudos são necessários a fim de elucidar a DW, seu tratamento ideal e remissão endoscópica da doença.
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