Avanços recentes na Doença de Alzheimer: revisão sistemática sobre métodos diagnósticos e abordagens terapêuticas
DOI:
https://doi.org/10.34119/bjhrv8n2-198Keywords:
Doença de Alzheimer, Alzheimer’s Disease, dementiaAbstract
A Doença de Alzheimer é a causa mais comum de demência e vem sendo cada vez mais reconhecida como um dos desafios médicos e socioeconômicos mais urgentes deste século. Nos últimos anos, houve avanços significativos na compreensão de sua patogênese, na identificação de fatores genéticos de risco e proteção, no desenvolvimento de novos biomarcadores sanguíneos e de imagem, além das primeiras evidências dos possíveis benefícios de terapias modificadoras da doença e intervenções no estilo de vida. Além disso, o surgimento de abordagens imunobiológicas abriu novas perspectivas terapêuticas, com ensaios clínicos explorando estratégias imunológicas direcionadas que demonstram um potencial promissor para modificar a progressão da doença.
References
Balkhi, Sahar et. al. Immune Modulation in Alzheimer’s Disease: From Pathogenesis to Immunotherapy. Cells, 2025. Feb, 12. v. 14, n. 4, p. 264.
Breijyeh, Zeinab et. al. Comprehensive Review on Alzheimer’s Disease: Causes and Treatment. Molecules. Basel, Switzerland, 2020. Dec. 9. v. 25, n. 24, p. 5789.
By, Samantha et. al. Alzheimer’s Disease Clinical Trials: What Have We Learned From Magnetic Resonance Imaging. Journal of Magnetic Resonance Imaging, 2024. Jun, 20. v. 61, n. 2, p. 579-594
Cao, Weili et al. Comparison of the efficacy of updated drugs for the treatment on the improvement of cognitive function in patients with Alzheimer 's disease: A systematic review and network meta-analysis. Amsterdam, Neuroscience, 2025. Jan 26. v. 565, p. 29-39.
Goetzl, Edward J. Current Developments in Alzheimer’s Disease. Am J Med, 2025. Jan. 1. v. 138, n. 1, p. 15-20.
Jia, Jianping. et. al. Biomarker Changes during 20 years preceding Alzheimer’s Disease. The New England Journal of Medicine, 2024. Feb, 21. v. 390, n. 8, p. 712-722.
Juengling, Freimut. et. al. PET Imaging in Dementia: Mini-Review and Canadian Perspective for Clinical Use. Canadian Journal of Neurological Sciences, 2025. Mar, 4. v. 52, p. 26-38.
Kciuk, Mateusz et. al. Alzheimer’s Disease as Type 3 Diabetes: Understanding the Link and Implications. International Journal of Molecular Sciences, 2024. Nov, 7. v. 25, n. 22, p. 119.
Liu, Enjie et. al. Updates in Alzheimer’s disease: from basic research to diagnosis and therapies. Transl Neurodegener, 2024. Sep. 4. v. 13, n. 45.
Mandal, Pravat et. al. The Missing Link in Antiamyloid Therapy. ACS Chemical Neuroscience, 2025. Jan, 14. v. 16, n. 3, p. 276-280.
Mertas, Beyza; Bosgelmez, Ipek. The role of Genetic, environmental, and dietary factors in Alzheimer’s Disease: A Narrative Review. International Journal of Molecular Sciences, 2025. Jan, 30. v. 26, n. 3, p. 1222.
Ren, Zijun et. al. Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis. BMC Neurosciences, 2025. Jan, 24. v. 26, n. 5.
Scheltens, Philip et. al. Alzheimer’s disease. London, Lancet, 2021. Apr. 24. v. 397, n. 10284, p. 1577-1590.
Self, Wade. et. al. Emerging diagnostics and therapeutics for Alzheimer's disease. Nature Medicine, 2023. Sep. 29. v. 9, p. 2187-2199.
Shahidehpour, Ryan et al. Exploring the link between dystrophic microglia and the spread of Alzheimer’s neuropathology. Brain, 2025. Jan, 1. v. 148, n. 1, p. 89-101.
Tenchov, Rumiana et. al. Alzheimer’s disease: Exploring the Landscape of Cognitive Decline. ACS Chem Neuroscience, 2024. Nov. 6. v. 15, n. 21, p. 3800-3827.
Twarowski, Bartosz et. al. Inflammatory Processes in Alzheimer’s Disease - Pathomechanism, Diagnosis and Treatment: A Review. Int J Mol Sci, 2023. Mar. 30. v. 30, n. 24, p. 6518.
Villain, Nicolas; Michalon, Robin. What is Alzheimer’s Disease? An analysis of nosological perspectives from the 20th and 21st centuries. European Journal of Neurology, 2024. Apr, 15. v. 31, n. 11.
Wang, Shuguang et. al. Mitochondrial dysfunction in Alzheimer’s disease: a key frontier for future targeted therapies. Frontiers in immunology, 2025. Jan, 14. v. 15.
Zheng, Qiuyang; Wang, Xin. Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy. Protein Cell, 2024. May, 11. v. 16, n. 2, p. 83-120.
