Tratamento profilático de migrânea com Δ -9-tetrahidrocanabinol

Authors

  • Anna Julia Souza Xavier
  • Jéssica Lopes Alves
  • Larissa Jordane Costa Coutinho
  • Pâmela Mylena Sousa Casseano
  • Flávia Gonçalves Vasconcelos

DOI:

https://doi.org/10.34119/bjhrv7n9-433

Keywords:

migrânea, THC, cannabis e canabinóides

Abstract

As terapias canabinóides estão ganhando força para o tratamento de diversas doenças, dentre elas, a migrânea. No entanto, ainda são necessários estudos para elucidar melhor o tratamento profilático e sintomático realizado com ela. Esta revisão de literatura tem o objetivo de analisar e sintetizar as evidências científicas disponíveis sobre a eficácia e segurança do Δ-9-tetraidrocanabinol (THC) como opção de tratamento profilático para a migrânea, visando identificar potenciais benefícios, mecanismos de ação, efeitos adversos e lacunas na literatura.

References

AGUILAR-SHEA, A. L.; DIAZ-DE-TERAN, J. Migraine review for general practice. Atencion primaria, 2022.

AVIRAM, J. et al. Migraine frequency decrease following prolonged medical cannabis treatment: A cross-sectional study. Brain sciences, 2020.

BARON, E. P. Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: What a long, strange trip it’s been ... Headache, 2015.

BARON, E. P. Medicinal properties of cannabinoids, terpenes, and flavonoids in Cannabis, and benefits in migraine, headache, and pain: an update on current evidence and Cannabis science. Headache Blackwell Publishing Inc., 2018.

BARON, E. P. et al. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. Journal of headache and pain, 2018.

BLAU J.N. Migraine: theories of pathogenesis.1992

CHANDWANI, B. et al. The Exploration of Cannabis and cannabinoid therapies for migraine. Springer, 2023.

COHEN, K.; WEIZMAN, A.; WEINSTEIN, A. Positive and negative effects of Cannabis and cannabinoids on health. Clinical Pharmacology and Therapeutics Nature Publishing Group, 2019.

D’ALMEIDA, S. F. F. et al. Perfil epidemiológico do SUS: enxaqueca em caráter de urgência no Brasil, entre 2017 e 2021. Brazilian Journal of Development, 2022.

DELEU, D.; HANSSENS, Y.; WORTHING, E. A. Symptomatic and prophylactic treatment of migraine: a critical reappraisal. 1998.

HA, H.; GONZALEZ, A.; ROSA, S. Migraine headache prophylaxis. Disponível em: https://familydoctor.org/condition/migraines/.>.

GRECO, R., DEMARTINI, C., ZANABONI, A. M., FRANCAVILLA, M., DE ICCO, R., AHMAD, L., & TASSORELLI, C. The endocannabinoid system and related lipids as potential targets for the treatment of migraine-related pain. John Wiley and Sons Inc, 2022.

KAUR, S.; SHARMA, N.; ROY, A. Role of Cannabinoids in Various Diseases: A Review. Current Pharmaceutical Biotechnology, 2021.

KHAN, J. et al. Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine. Biomedicine and Pharmacotherapy. Elsevier Masson, 2021.

KOPRUSZINSKI, C. M. et al. Cannabinoids induce latent sensitization in a preclinical model of medication overuse headache. Cephalalgia, 2020.

LOBO, B. L.; COOKE, S. C.; LANDY, S. H. Symptomatic Pharmacotherapy of Migraine Clinical therapeutics, 1999.

LUCAS, C. J.; GALETTIS, P.; SCHNEIDER, J. The pharmacokinetics and the pharmacodynamics of cannabinoids. British Journal of Clinical Pharmacology. Blackwell Publishing Ltd, 2018.

LÜLLMANN, H.; MOHR, K.; HEIN, L. Farmacologia - 7a Edição. 2020.

MECHTLER, L. L.; GENGO, F. M.; BARGNES, V. H. Cannabis and migraine: it’s complicated. 2021.

MURILLO-RODRIGUEZ, E.; PANDI-PERUMAL, S. R.; MONTII, J. M. Cannabinoids and neuropsychiatric disorders advances in experimental medicine and biology. 2020. Disponível em: <http://www.springer.com/series/5584>.

POUDEL, S. et al. Medical Cannabis, headaches, and migraines: a review of the current literature. Cureus, 2021.

PULEDDA, F. et al. Migraine: from pathophysiology to treatment. Journal of Neurology. Springer Science and Business Media Deutschland GmbH, 2023.

RITTER, J. M. et al. RANG & DALE Farmacologia. 2020.

SCHILLING, S.; MELZER, R.; MCCABE, P. F. Current Biology Cannabis sativa. Current biology, 2019.

VINCENT, M. B. Fisiopatologia da enxaqueca. Arq Neuropsiquiatra, 1998.

MELHADO, E. M. Consenso da Sociedade Brasileira de Cefaleia (SBCe) para o tratamento profilático da migrânea episódica. Academia Brasileira de Neurologia, 2021.

CARNEIRO, C. A. P. Sexo e percepção da dor e analgesia. SciELO Brasil, 2011. Disponível em: < https://www.scielo.br/j/rba/a/kT4RHqWnzSHMtDFTcwcVf3J/#>.

BROOKS-RUSSEL, A. et al. Effects of acute cannabis inhalation on reaction time, decision-making, and memory using a tablet-based application. Journal of Cannabis Research, 2024. Disponível em: < https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-024-00215-1#Sec14>.

SHERPA, M.L.et al. Efficacy and Safety of Medical Marijuana in Migraine Headache: A Systematic Review. Cureos Part of springer nature. Dezembro,2022. Disponível em:< https://www.cureus.com/articles/118190-efficacy-and-safety-of-medical-marijuana-in-migraine-headache-a-systematic-review#!/>.

KHYROUG, L. et al. Emerging Role of (Endo)Cannabinoids in Migraine. Frontiers in Pharmacology. Abril,2018. Disponível em: < https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00420/full>.

Published

12/23/2024

How to Cite

XAVIER, A. J. S.; ALVES, J. L.; COUTINHO, L. J. C.; CASSEANO, P. M. S.; VASCONCELOS, F. G. Tratamento profilático de migrânea com Δ -9-tetrahidrocanabinol. Brazilian Journal of Health Review, [S. l.], v. 7, n. 9, p. e76145, 2024. DOI: 10.34119/bjhrv7n9-433. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/76145. Acesso em: 18 oct. 2026.

Issue

Section

Original Papers