Avanços recentes de metodologias analíticas por cromatografia líquida de alta eficiência para determinação de teor de ácido ascórbico em formulações farmacêuticas
DOI:
https://doi.org/10.34119/bjhrv7n9-212Keywords:
vitamina C, ácido ascórbico, Cromatografia Líquida de Alta Eficiência (HPLC), controle de qualidade, degradação de vitamina CAbstract
A vitamina C (ácido ascórbico) é responsável por um conjunto de funções sintéticas e bioquímicas e imunológicas. Contudo, a sua deficiência no sistema fisiológico produz diversos mecanismos patológicos, sendo assim, amplamente prescrita na prática clínica. Neste sentido, diversas indústrias farmacêuticas possuem no seu portifólio medicamentos contendo a vitamina C como princípio ativo. No âmbito do processo produtivo, controle de qualidade e registro na agência nacional de vigilância sanitária (ANVISA), é necessário desenvolver e validar metodologias analíticas capazes de determinar de maneira eficiente o teor e seus respectivos produtos de degradação. Assim, o presente estudo visa descrever sistematicamente as metodologias analíticas por cromatografia líquida de alta eficiência (HPLC) descritas na literatura (2023-2024) para determinação do teor de vitamina C. Ademais, uma análise crítica das condições cromatográficas, limitações e potenciais aplicações foram descritas e discutidas.
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