Tratamento de candidíase oral em pacientes com HIV/AIDS: revisão narrativa
DOI:
https://doi.org/10.34119/bjhrv7n9-033Keywords:
candidíase bucal, Candida albicans, infecções oportunistas relacionadas com a AIDSAbstract
O vírus HIV tem impactado a saúde global desde os anos 80, e a candidíase oral é uma das primeiras manifestações em pacientes imunossuprimidos por essa infecção. O objetivo deste trabalho é revisar as opções terapêuticas para o tratamento da candidíase oral em pacientes com HIV/AIDS, considerando a eficácia, segurança e novas abordagens. A metodologia empregada foi uma revisão narrativa da literatura científica, abrangendo artigos publicados entre 2014 e 2024 nas bases de dados PubMed, Cochrane Library e Science Direct. Foram analisados estudos que compararam tratamentos tradicionais, como fluconazol e nistatina, além de novas terapias, como a fotodinâmica. Os resultados indicam que o fluconazol continua sendo o antifúngico mais eficaz na cura clínica e micológica, no entanto, a resistência ao fluconazol tem sido uma preocupação crescente. Em contraste, a nistatina se mostrou segura, mas com menor eficácia em relação aos antifúngicos sistêmicos. A terapia fotodinâmica, quando combinada a antifúngicos convencionais, apresentou bons resultados, reduzindo a recidiva da infecção e a resistência medicamentosa.
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