Endocervical adenocarcinoma secondary to HPV in a young woman

Authors

  • Bruna Mariah Martins Batista Lopes
  • Ana Carolina Fernandes Dala Riva
  • Luísa de Oliveira e Silva
  • Gabriel Canhete Machado
  • Glaucia Alves de Carvalho
  • Aline Scherer
  • Bruna Lagemann
  • Isadora Bolfarini Guiotti Mettifogo
  • Gabriela Paladini Cardoso Medina

DOI:

https://doi.org/10.34119/bjhrv7n5-477

Keywords:

endocervical adenocarcinoma, HPV, Cervical Cancer, smoking, vaccination

Abstract

Considering the relationship between persistent HPV infections and the development of endocervical adenocarcinomas in young women, this study aims to report a rare case of invasive endocervical adenocarcinoma in a 28-year-old patient. To this end, clinical follow-up was carried out for the patient, who had risk factors such as smoking, early sexual debut, and lack of HPV vaccination. The diagnosis was made through biopsy and conization, followed by laparoscopic hysterectomy. It is observed that even in young women, persistent high-risk HPV infections can lead to the development of neoplasms, highlighting the importance of vaccination and early screening. It is concluded that individualized management and early diagnosis are essential for successful treatment in rare cases like this.

References

Bruni L, Albero G, Serrano B, et al. Human papillomavirus and related diseases in Brazil. Summary Report 2022. https://www.hpvcentre.net/statistics/reports/BRA.pdf

zur Hausen H. Papillomaviruses in human cancers. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-02-0010.

Stanley M. HPV vaccination and cervical cancer prevention. Nature Reviews Clinical Oncology. https://doi.org/10.1038/nrclinonc.2010.128.

Kjaer SK, Frederiksen K, Lacey CJ, et al. High-risk HPV is related to adenocarcinoma in situ and adenocarcinoma of the cervix. International Journal of Cancer. https://doi.org/10.1002/ijc.24884.

Muñoz N, Castellsagué X, de González AB, et al. HPV in the etiology of squamous cell cervical cancer. Vaccine. https://doi.org/10.1016/j.vaccine.2006.05.001.

Schlecht NF, Kulaga S, Robison K, et al. Early sexual initiation as a risk factor for cervical cancer: a review. Cancer Epidemiology, Biomarkers & Prevention. https://doi.org/10.1158/1055-9965.EPI-01-0225.

Gakidou E, Nordhagen S, Obermeyer Z. Coverage of cervical cancer screening in 57 countries: low average levels and large inequalities. PLoS Medicine. https://doi.org/10.1371/journal.pmed.0050132.

Saslow D, Solomon D, Lawson HW, et al. American Cancer Society guideline for screening and management of cervical cancer precursors. CA: A Cancer Journal for Clinicians. https://doi.org/10.3322/caac.21139.

Garland SM, Hernandez-Avila M, Wheeler CM, et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa0617416.

Pinto LA, Koutsky LA, Castle PE, et al. Human papillomavirus vaccination: its role in preventing cervical cancer and other HPV-related diseases. American Journal of Public Health. https://doi.org/10.2105/AJPH.2015.302989.

Chesson HW, Ekwueme DU, Sabatino SA, et al. The cost-effectiveness of human papillomavirus vaccination and cervical cancer screening. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jis264.

Castellsagué X, Fernández E, de Sanjosé S, et al. The role of HPV in the aetiology of cervical cancer. Vaccine. https://doi.org/10.1016/j.vaccine.2008.06.005.

Garland SM, Liu B, Hogg D, et al. Impact of the human papillomavirus vaccination program on cervical cancer incidence and mortality. Cancer Epidemiology, Biomarkers & Prevention. https://doi.org/10.1158/1055-9965.EPI-20-1125.

Smith JS, Lindsay L, Hoots B, et al. Human papillomavirus testing in cervical cancer screening: a meta-analysis. JAMA. https://doi.org/10.1001/jama.298.7.770.

Wheeler CM, Kjaer SK, Sigurdsson K, et al. Efficacy of a quadrivalent HPV vaccine against HPV infection and disease in females. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa0806077.

Levinson KL, Cohen SA. The impact of HPV vaccination programs on cervical cancer rates: A review. Public Health Reports. https://doi.org/10.1177/003335491412900405.

Holman DM, Benard VB, Roland KB, et al. Cervical cancer screening among U.S. women aged 30-65 years: 2018-2019. Morbidity and Mortality Weekly Report. https://doi.org/10.15585/mmwr.mm6920a1.

Wright TC, Behrens C, Kato I, et al. Evaluation of conization for the treatment of early-stage cervical cancer. Journal of Clinical Oncology. https://doi.org/10.1200/JCO.2010.30.7405.

Schenck U, Hill H, Montoya R, et al. Management strategies for endocervical adenocarcinoma: a review. Gynecologic Oncology. https://doi.org/10.1016/j.ygyno.2020.06.024.

Dinkelspiel HE, DeSimone CP, McGree ME, et al. Screening and treatment options for endocervical adenocarcinoma: A review. Current Opinion in Obstetrics and Gynecology. https://doi.org/10.1097/GCO.0000000000000785.

Downloads

Published

10/15/2024

How to Cite

LOPES, B. M. M. B.; RIVA, A. C. F. D.; SILVA, L. de O. e; MACHADO, G. C.; CARVALHO, G. A. de; SCHERER, A.; LAGEMANN, B.; METTIFOGO, I. B. G.; MEDINA, G. P. C. Endocervical adenocarcinoma secondary to HPV in a young woman. Brazilian Journal of Health Review, [S. l.], v. 7, n. 5, p. e73667, 2024. DOI: 10.34119/bjhrv7n5-477. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/73667. Acesso em: 19 oct. 2026.

Issue

Section

Original Papers