Abordagens terapêuticas para o manejo da disfunção sexual induzida por inibidores seletivos da recaptação de serotonina
DOI:
https://doi.org/10.34119/bjhrv7n4-469Keywords:
inibidores seletivos da recaptação de serotonina, disfunção sexual, homens, ejaculação, soluçõesAbstract
Este estudo investiga a prevalência e o impacto da disfunção sexual induzida por inibidores seletivos da recaptação de serotonina (ISRSs), amplamente usados no tratamento da depressão. Os ISRSs são associados a efeitos colaterais sexuais significativos, incluindo redução do desejo sexual, dificuldades na excitação, e retardo na ejaculação, afetando negativamente a qualidade de vida e a adesão ao tratamento. A revisão destaca a necessidade de abordagens terapêuticas eficazes, como a redução da dose de ISRSs, substituição por medicamentos com menor impacto sexual ou a adição de medicamentos adjuvantes. A metodologia adotada consistiu na realização de buscas em bases de dados reconhecidas, resultando na seleção inicial de 35 artigos. Desses, 21 atenderam aos critérios previamente estabelecidos. A pesquisa enfatiza a importância de uma comunicação clara entre médicos e pacientes para o manejo adequado desses efeitos colaterais.
References
ARIAS, F. et al. Disfunciones sexuales inducidas por los inhibidores de la recaptación de serotonina. Atención Primaria, v. 26, n. 6, p. 389–394, 2000.
ASHTON, A. K.; ROSEN, R. C. Bupropion as an Antidote for Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction. The Journal of Clinical Psychiatry, v. 59, n. 3, p. 112–115, 15 mar. 1998.
BEN-SHEETRIT, J. et al. Post-SSRI Sexual Dysfunction. Journal of Clinical Psychopharmacology, v. 35, n. 3, p. 273–278, jun. 2015.
CORDÁS, T. A.; LARANJEIRAS, M. Efeitos colaterais dos psicofármacos na esfera sexual. Archives of Clinical Psychiatry (São Paulo), v. 33, n. 3, p. 168–173, 2006.
DAS, S. Psychotropic Use and Sexual Dysfunction: Is There a Practical Solution? Journal of Trauma & Treatment, v. 06, n. 04, 2017.
DE JONG, T. R. et al. Oxytocin Involvement in SSRI-Induced Delayed Ejaculation: A Review of Animal Studies. The Journal of Sexual Medicine, v. 4, n. 1, p. 14–28, jan. 2007.
GITLIN, M. J. Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches. The Journal of Clinical Psychiatry, v. 55, n. 9, p. 406–413, 1 set. 1994.
HIRSCHFELD, R. M. A. Long-term side effects of SSRIs: sexual dysfunction and weight gain. The Journal of Clinical Psychiatry, v. 64 Suppl 18, p. 20–24, 2003.
JING, E.; STRAW-WILSON, K. Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: A narrative literature review. Mental Health Clinician, v. 6, n. 4, p. 191–196, jul. 2016.
KRONSTEIN, P. D. et al. Summary of Findings From the FDA Regulatory Science Forum on Measuring Sexual Dysfunction in Depression Trials. The Journal of Clinical Psychiatry, v. 76, n. 08, p. 1050–1059, 26 ago. 2015.
MONTEJO, A. L. et al. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. The Journal of Clinical Psychiatry, v. 62 Suppl 3, p. 10–21, 2001.
MONTEJO-GONZÀLEZ, A. L. et al. Fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. Journal of Sex & Marital Therapy, v. 23, n. 3, p. 176–194, set. 1997.
PELEG, L. C. et al. Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors. Sexual Medicine Reviews, out. 2021.
ROTHMORE, J. Antidepressant‐induced sexual dysfunction. Medical Journal of Australia, v. 212, n. 7, p. 329–334, 15 mar. 2020.
SAFA, M. et al. Study of effects of selective serotonin reuptake inhibitors on stages of sexual function in Iranian patients with major depressive disorder. Therapeutic Advances in Psychopharmacology, v. 3, n. 6, p. 306–313, 23 maio 2013.
SERRETTI, A.; CHIESA, A. Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. Journal of Clinical Psychopharmacology, v. 29, n. 3, p. 259–266, 1 jun. 2009.
STAHL, S. M. Mechanism of action of serotonin selective reuptake inhibitors. Journal of Affective Disorders, v. 51, n. 3, p. 215–235, dez. 1998.
STRYJER, R. et al. Trazodone for the Treatment of Sexual Dysfunction Induced by Serotonin Reuptake Inhibitors. Clinical Neuropharmacology, v. 32, n. 2, p. 82–84, mar. 2009.
STRYJER, R. et al. Trazodone for the Treatment of Sexual Dysfunction Induced by Serotonin Reuptake Inhibitors. Clinical Neuropharmacology, v. 32, n. 2, p. 82–84, mar. 2009.
WALDINGER, M. D. et al. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. International Journal of Impotence Research, v. 16, n. 4, p. 369–381, 1 ago. 2004.
WALDINGER, M. D. et al. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. International Journal of Impotence Research, v. 16, n. 4, p. 369–381, 1 ago. 2004.
WILLIAMS, V. S. L. et al. Estimating the Prevalence and Impact of Antidepressant-Induced Sexual Dysfunction in 2 European Countries. The Journal of Clinical Psychiatry, v. 67, n. 02, p. 204–210, 15 fev. 2006.
ZISOOK, S. et al. Use of Bupropion in Combination with Serotonin Reuptake Inhibitors. Biological Psychiatry, v. 59, n. 3, p. 203–210, fev. 2006.


