Psychiatric disorders in seropositive human for Toxoplasma gondii, with calcification in left temporal lobe - case report
DOI:
https://doi.org/10.34119/bjhrv7n4-099Keywords:
Depression, behavior, neurotoxoplasmosis, neuroinfection, panic syndromeAbstract
The aim of this study was to report the occurrence of chronic psychiatric disorders in an elderly woman, seropositive for Toxoplasma gondii and with calcification formation in the left temporal lobe. The patient aged 65 years old was diagnosed with depressive disorder and panic with no obvious cause, after an episode of infection by dengue hemorrhagic fever. There were no changes in biochemical, hematological and hormonal parameters. By means of magnetic resonance imaging was detected a small calcification in the right temporal lobe. The patient was shown unresponsive to treatment with antidepressants and other therapeutic methods. Was detected in the serological analysis high titer of IgG, low titers for IgA and negative for IgM anti-T. gondii. Thus, neuropsychiatric disorders were described in an elderly woman seropositive for T. gondii, with calcification in the left temporal lobe, manifesting itself primarily in forms of depressive syndrome and panic, with poor response to treatment with antidepressant drugs and neurostimulation.
References
Hutchinson, W.M., Bradley, M., Cheyne, W.M., Wells, B.W., Hay, J., 1980. Behavoural abnormalities in Toxoplasma-infected mice. Ann Trop Med Parasitol. 74, 337-345.
Jones-Brando, L., Torrey, E.F., Yolken, R., 2003. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res. 62, 237-244.
Kar, N., Misra, B., 2004. Toxoplasma seropositivity and depression: a case report. BMC Psychiatry 4, doi: 10.1186/1471-244X-4-1.
Webster, J.P., Lamberton, P.H.L., Donnelly, C.A., Torrey, E.F., 2006. Parasites as causative agents of human affective disorders? The impact on anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii’s ability to alter host behavior. Proceedings. Biol Sci. 273, 1023-1030.
Yolken, R.H., Bechmann, S., Rouslanova, I., Lillehoj, E., Ford, G., Torrey, E.F., Schroeder, J., 2001. Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia. Clin Infect Dis. 32,842-844.
Zhu S., 2009. Psychosis may be associated with toxoplasmosis. Med Hypotheses. 73, 799-801.
