Intoxicação medicamentosa por AINES: uma revisão integrativa
DOI:
https://doi.org/10.34119/bjhrv7n4-037Keywords:
anti-inflamatórios não esteroidais, AINEs, lesão renal, farmacovigilância, segurança do pacienteAbstract
Os anti-inflamatórios não esteroidais (AINEs) são amplamente utilizados devido à sua eficácia no tratamento de condições inflamatórias, osteoartrites e controle da dor. No entanto, seu uso prolongado está associado a complicações renais, gastrointestinais e hepáticas, destacando a importância de uma avaliação cuidadosa dos riscos e benefícios. Este estudo consistiu em uma revisão integrativa da literatura, realizada nas bases de dados BVS/Lilacs, PubMed, Scielo e Science Direct. Foram utilizados termos de pesquisa como "AINE", "Anti-Inflamatório", "Intoxicação" e "Farmacovigilância" para identificar estudos relevantes publicados entre 2015 e 2024. Um total de 18 artigos foram selecionados para análise após exclusão de duplicidades e critérios de inclusão e exclusão. Os resultados destacaram associações entre o uso de AINEs e lesão renal aguda, doença renal crônica, sangramento gastrointestinal e doença hepática aguda, ressaltando a necessidade de uma abordagem individualizada na prescrição desses medicamentos. A seletividade para a COX e os grupos químicos dos AINEs influenciaram no manejo dos efeitos colaterais, enfatizando a importância da vigilância regular dos pacientes. Conclui-se, que uma prescrição cuidadosa e vigilância adequada são essenciais para garantir uma terapia eficaz e segura com AINEs, contribuindo para a segurança dos pacientes e orientação da prática clínica.
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