Aspectos clínicos e moleculares do Alzheimer – revisão de literatura
DOI:
https://doi.org/10.34119/bjhrv7n2-465Keywords:
Doença de Alzheimer, aspectos moleculares, aspectos clínicos, fisiopatologia, tratamento do AlzheimerAbstract
A doença de Alzheimer (DA) é um distúrbio neurodegenerativo multifatorial progressivo caracterizado pelo acúmulo de agregados anormais de proteínas no cérebro, como placas de amiloide e emaranhados de tau, o que leva ao declínio gradual das habilidades cognitivas e, eventualmente, prejudica o funcionamento diário da função mental. O objetivo desse estudo foi descrever de forma ampla os aspectos clínicos e moleculares da doença de Alzheimer para os profissionais da saúde. As bases de dados que foram utilizadas nessa revisão incluem Scientific Electronic Library Online (SciELO) e National Library of Medicine (MedLine/PubMed). Dentre os artigos científicos que foram consultados, estes compreendem àqueles publicados nos últimos dez anos. Os trabalhos aqui discutidos, de maneira geral, abordam sobre a importância molecular e clínica da DA, tendo em vista que ela é complexa e multifatorial. Em suma, o processo de desenvolvimento científico-teórico sobre a DA não pode estagnar, e é de extrema importância que pesquisas nesse tema sejam publicadas, visando, assim, melhorar o processo de interpretação e compreensão da fisiopatologia da DA.
References
ASHRAF, Ghulam M. et al. The possibility of an infectious etiology of Alzheimer disease. Molecular neurobiology, v. 56, p. 4479-4491, 2019.
BAI, Renren et al. Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease. Ageing research reviews, v. 77, p. 101619, 2022.
BARBOSA, Felipe Oliveira et al. Doença de Alzheimer e o uso de memantina: Uma revisão da literatura. Brazilian Journal of Health Review, v. 3, n. 2, p. 2415-2425, 2020.
BERG-WEGER, Marla; STEWART, Daniel B. Non-pharmacologic interventions for persons with dementia. Missouri medicine, v. 114, n. 2, p. 116, 2017.
BIR, Shyamal C.; CHERNYSHEV, Oleg Y.; MINAGAR, Alireza. Roles of toll-like receptors in pathophysiology of Alzheimer’s Disease and multiple sclerosis. In: Neuroinflammation. Academic Press, 2018. p. 541-562.
BLEIBEL, Malak et al. The effect of music therapy on cognitive functions in patients with Alzheimer’s disease: a systematic review of randomized controlled trials. Alzheimer's Research & Therapy, v. 15, n. 1, p. 65, 2023.
BREIJYEH, Zeinab; KARAMAN, Rafik. Comprehensive review on Alzheimer’s disease: Causes and treatment. Molecules, v. 25, n. 24, p. 5789, 2020.
CHEIGNON, Clémence et al. Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox biology, v. 14, p. 450-464, 2018.
DE JR DE-PAULA, Vanessa; FORLENZA, Andrea S.; FORLENZA, Orestes V. Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease. Pharmacological research, v. 136, p. 29-34, 2018.
GOYAL, Deepti et al. Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: Potential therapeutics of Alzheimer’s disease. ACS combinatorial science, v. 19, n. 2, p. 55-80, 2017.
GUO, Lan; TIAN, Jing; DU, Heng. Mitochondrial dysfunction and synaptic transmission failure in Alzheimer’s disease. Journal of Alzheimer's Disease, v. 57, n. 4, p. 1071-1086, 2017.
HAMPEL, Harald et al. The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain, v. 141, n. 7, p. 1917-1933, 2018.
HENEKA, Michael T.; GOLENBOCK, Douglas T.; LATZ, Eicke. Innate immunity in Alzheimer's disease. Nature immunology, v. 16, n. 3, p. 229-236, 2015.
HUANG, Fang . CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease. Alzheimer's & Dementia, v. 15, n. 2, p. 217-231, 2019.
ITTNER, Arne; ITTNER, Lars M. Dendritic tau in Alzheimer’s disease. Neuron, v. 99, n. 1, p. 13-27, 2018.
KHAN, Sahil; BARVE, Kalyani H.; KUMAR, Maushmi S. Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer’s disease. Current neuropharmacology, v. 18, n. 11, p. 1106-1125, 2020.
KINNEY, Jefferson W. et al. Inflammation as a central mechanism in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, v. 4, p. 575-590, 2018.
LEANZA, Giampiero; GULINO, Rosario; ZOREC, Robert. Noradrenergic hypothesis linking neurodegeneration-based cognitive decline and astroglia. Frontiers in Molecular Neuroscience, v. 11, p. 254, 2018.
LUCA, Maria et al. Gut microbiota in Alzheimer’s disease, depression, and type 2 diabetes mellitus: The role of oxidative stress. Oxidative medicine and cellular longevity, 2019.
MACHADO, Annelisa Pimentel Rezende; CARVALHO, Izabella Oliveira; DA ROCHA SOBRINHO, Hermínio Maurício. Neuroinflamação na doença de Alzheimer. Revista brasileira militar de ciências, v. 6, n. 14, 2020.
MAHMOUDIANDEHKORDI, Siamak et al. Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—an emerging role for gut microbiome. Alzheimer's & Dementia, v. 15, n. 1, p. 76-92, 2019.
RAJASEKHAR, K.; GOVINDARAJU, Thimmaiah. Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease. RSC advances, v. 8, n. 42, p. 23780-23804, 2018.
RAJASEKHAR, K.; MEHTA, Kapilkumar; GOVINDARAJU, Thimmaiah. Hybrid multifunctional modulators inhibit multifaceted Aβ toxicity and prevent mitochondrial damage. ACS Chemical Neuroscience, v. 9, n. 6, p. 1432-1440, 2018.
ROBERT, Anne et al. Regulation of copper and iron homeostasis by metal chelators: A possible chemotherapy for Alzheimer’s disease. Accounts of chemical research, v. 48, n. 5, p. 1332-1339, 2015.
SOLOMON, Alina et al. Effect of the apolipoprotein E genotype on cognitive change during a multidomain lifestyle intervention: a subgroup analysis of a randomized clinical trial. JAMA neurology, v. 75, n. 4, p. 462-470, 2018.
SUMNER, Isabelle L. et al. Antibody engineering for optimized immunotherapy in Alzheimer's disease. Frontiers in Neuroscience, v. 12, p. 254, 2018.
TOBBIN, Isabella Arantes et al. Doença de Alzheimer: uma revisão de literatura Alzheimer's Disease: A Literature Review. Brazilian Journal of Health Review, v. 4, n. 3, p. 14232-14244, 2021.
ULLAH, A. et al. Glicogênio sintase quinase-3 (GSK-3), uma enzima mágica: seu papel no diabetes mellitus e na homeostase da glicose: interações com fluoroquinolonas. Uma mini-revisão. Brazilian Journal of Biology, v. 83, 2021.
VAKALOPOULOS, Costa. Alzheimer’s disease: the alternative serotonergic hypothesis of cognitive decline. Journal of Alzheimer's Disease, v. 60, n. 3, p. 859-866, 2017.
VAN DYCK, Christopher H. Anti-amyloid-β monoclonal antibodies for Alzheimer’s disease: pitfalls and promise. Biological psychiatry, v. 83, n. 4, p. 311-319, 2018.
YUN, Hyung-Mun et al. Serotonin 6 receptor controls Alzheimer’s disease and depression. Oncotarget, v. 6, n. 29, p. 26716, 2015.
ZHANG, Tianlang et al. Comparative epidemiological investigation of Alzheimer’s disease and colorectal cancer: the possible role of gastrointestinal conditions in the pathogenesis of AD. Frontiers in aging neuroscience, v. 10, p. 176, 2018.
