Diferentes tipos e protocolos de esclerosantes vasculares no tratamento das má formações vasculares orais: revisão literária

Authors

  • Luísa de Lanna Reis Rocha
  • Ana Carolina Candelas Peixoto
  • João César Guimarães Henriques
  • Karla Zancopé

DOI:

https://doi.org/10.34119/bjhrv7n2-424

Keywords:

hemangioma, malformação vascular, escleroterapia

Abstract

Revisar a literatura mundial a fim de avaliar os diferentes protocolos de tipos diversos de esclerosantes vasculares utilizados no tratamento das malformações vasculares presentes na cavidade oral. E por fim apresentar as possibilidades encontradas e ilustrá-las de forma ordenada. Foi realizada uma revisão da literatura através da busca ativa na base de dados Medline, via PubMed. Como critérios de inclusão, foram selecionados artigos que tenham avaliado  o tratamento de malformações vasculares orais, publicados a partir do ano 2000, nas línguas portuguesa, inglesa, espanhola ou francês com pesquisas envolvendo exclusivamente seres humanos. Foram elencados em uma tabela 23 diferentes protocolos de tratamento com agentes esclerosantes para malformações na região de cabeça e pescoço, de modo que todos culminaram com resultados satisfatórios aos pacientes. Esclerosantes vasculares são opções de tratamento seguros e efetivos na regressão e remissão de malformações vasculares orais. O oleato de etanolamina é um fármaco esclerosante muito utilizado no território brasileiro e dispõe de diversos protocolos de uso com respaldo na literatura científica.

References

Fernandes D, Elias R, Santos-Silva A, Vargas P, Lopes M. Benign oral vascular lesions treated by sclerotherapy with ethanolamine oleate: A retrospective study of 43 patients. Medicina Oral Patología Oral y Cirugia Bucal. 2018;

Batista Rodrigues Johann AC, Aguiar MCF, Vieira do Carmo MA, Gomez RS, Castro WH, Mesquita RA. Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: An open clinical trial with 30 lesions. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2005 Nov;100(5):579–84.

John H, Padmashree S, Pandeshwar P, Innus S. Arteriovenous malformation of the parotid gland: Diagnostic perspective- A case report. Indian Journal of Dental Research. 2020;31(1):164.

Sindel A, Sayan A, Özgür Ö, Sindel T, Ilankovan V. Percutaneous treatment of orofacial vascular malformations. British Journal of Oral and Maxillofacial Surgery. 2018 Apr;56(3):206–11.

Wang YA, Zheng JW, Zhu HG, Ye WM, He Y, Zhang ZY. Sclerotherapy of voluminous venous malformation in head and neck with absolute ethanol under digital subtraction angiography guidance. Phlebology: The Journal of Venous Disease. 2010 May 17;25(3):138–44.

Min H-G, Kim S-G, Oh J-S, You J-S. Sclerotherapy using 1% sodium tetradecyl sulfate to treat a vascular malformation: a report of two cases. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2015;41(6):322.

Sousa Costa JR, Torriani MA, Hosni ES, D’Avila OP, de Figueiredo PJ. Sclerotherapy for Vascular Malformations in the Oral and Maxillofacial Region: Treatment and Follow-Up of 66 Lesions. Journal of Oral and Maxillofacial Surgery. 2011 Jun;69(6):e88–92.

Ademi Abdyli R, Abdyli Y, Perjuci F, Gashi A, Agani Z, Ahmedi J. Sclerotherapy of Intraoral Superficial Hemangioma. Case Reports in Dentistry. 2016;2016:1–5.

da Silva WB, Ribeiro ALR, de Menezes SAF, de Jesus Viana Pinheiro J, de Melo Alves-Junior S. Oral capillary hemangioma: A clinical protocol of diagnosis and treatment in adults. Oral and Maxillofacial Surgery. 2013 Nov 22;18(4):431–7.

Meziane M, Boulaadas M, Eabdenbitsen A, Dib N, Essakalli L, Kzadri M. Hémangiome du masséter opéré par voie intra-orale. Revue de Stomatologie et de Chirurgie Maxillo-faciale. 2010 Jun;111(3):168–71.

Nagler RM, Braun J, Daitzchman M, Peled M, Laufer D. Selective embolization for head and neck vasculopathies. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2002 Feb;93(2):127–31.

Hassani A, Khojasteh A, Vahid R. Management of mandibular vascular malformation with sclerotherapy. Report of two cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006 Jul;102(1):99–103.

Kripal K, Rajan S, Ropak B, Jayanti I. Cavernous Hemangioma of the Tongue. Case Reports in Dentistry. 2013;2013:1–3.

Reddy GSivaP. Intralesional Sclerotherapy - A Novel Approach for The Treatment of Intraoral Haemangiomas. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. 2016;

Couto DAF, Ito FA, Lima HG de, Novais JD, Novais JB, Dallazen E, et al. Sclerotherapy for Extensive Vascular Malformation in the Tongue. Journal of Craniofacial Surgery. 2019 Nov;30(8):e796–9.

Manzano BR, Premoli AM, Santaella NG, Ikuta CRS, Rubira CMF, Santos PS da S. Sclerotherapy as an esthetic indication in oral vascular malformations: a case series. Anais Brasileiros de Dermatologia. 2019 Sep;94(5):521–6.

Chen A-W, Liu S-H, Huang Y-Y, Wang T. Preliminary Experience With More Stable Polidocanol Foam in Sclerotherapy of Head and Neck Venous Malformations. Dermatologic Surgery. 2018 Nov;44(11):1421–6.

Garg S, Kumar S, Singh YB. Intralesional radiofrequency in venous malformations. British Journal of Oral and Maxillofacial Surgery. 2015 Mar;53(3):213–6.

Mishra M, Singh G, Gaur A, Tandon S, Singh A. Role of sclerotherapy in management of vascular malformation in the maxillofacial region: Our experience. National Journal of Maxillofacial Surgery. 2017;8(1):64.

Ribeiro MC, de Mattos Camargo Grossmann S, do Amaral MBF, de Castro WH, Navarro TP, Procopio RJ, et al. Effectiveness and safety of foam sclerotherapy with 5% ethanolamine oleate in the treatment of low-flow venous malformations in the head and neck region: a case series. International Journal of Oral and Maxillofacial Surgery. 2018 Jul;47(7):900–7.

Laviv A, Maly A, Abu-Tair J. Large facial lymphatic malformation treatment using sclerosing agent followed by surgical resection: clinical and pathology report. Oral and Maxillofacial Surgery. 2017 Jul 22;21(3):363–9.

Bai Y, Jia J, Huang X-X, Alsharif MJ, Zhao J-H, Zhao Y-F. Sclerotherapy of Microcystic Lymphatic Malformations in Oral and Facial Regions. Journal of Oral and Maxillofacial Surgery. 2009 Feb;67(2):251–6.

Judith N, Ulrike E, Siegmar R, Matthias N, Jürgen H. Current concepts in diagnosis and treatment of venous malformations. Journal of Cranio-Maxillofacial Surgery. 2014 Oct;42(7):1300–4.

Akita S, Akino K, Tanaka K, Anraku K, Yano H, Hirano A. Therapeutic Choice for Craniofacial Venous Malformations. Journal of Craniofacial Surgery. 2006 Jul;17(4):729–35.

Kishi K, Morita N, Terada T, Sato M. Dose-saving isolation procedure in percutaneous ethanol sclerotherapy for venous malformations. Phlebology: The Journal of Venous Disease. 2013 Mar 18;29(5):276–86.

Su L, Fan X, Zheng L, Zheng J. Absolute Ethanol Sclerotherapy for Venous Malformations in the Face and Neck. Journal of Oral and Maxillofacial Surgery. 2010 Jul;68(7):1622–7.

Motamedi MHK, Behnia H, Motamedi MRK. Surgical technique for the treatment of high-flow arteriovenous malformations of the mandible. Journal of Cranio-Maxillofacial Surgery. 2000 Aug;28(4):238–42.

Górriz-Gómez E, Vicente-Barrero M, Loras-Caballero ML, Bocanegra-Pérez S, Castellano-Navarro JM, Pérez-Plasencia D, et al. Sclerotherapy of face and oral cavity low flow vascular malformations: our experience. British Journal of Oral and Maxillofacial Surgery. 2014 Jan;52(1):43–7.

Kato C de NA de O, Ribeiro MC, do Amaral MBF, Grossmann S de MC, de Aguiar MCF, Mesquita RA. Experience with 5% ethanolamine oleate for sclerotherapy of oral vascular anomalies: A cohort of 15 consecutive patients. Journal of Cranio-Maxillofacial Surgery. 2019 Jan;47(1):106–11.

Stimpson P, Hewitt R, Barnacle A, Roebuck DJ, Hartley B. Sodium tetradecyl sulphate sclerotherapy for treating venous malformations of the oral and pharyngeal regions in children. International Journal of Pediatric Otorhinolaryngology. 2012 Apr;76(4):569–73.

Agarwal S. Treatment of Oral Hemangioma with 3% Sodium Tetradecyl Sulfate: Study of 20 Cases. Indian Journal of Otolaryngology and Head & Neck Surgery. 2011 Apr 13;64(3):205–7.

Hontanilla B, Qiu S-S, Marre D. Surgical management of large venous malformations of the lower face. British Journal of Oral and Maxillofacial Surgery. 2013 Dec;51(8):752–6.

Sigaux N, Viremouneix L, Guibaud L, Breton P. Malformations veineuses superficielles cervico-faciales. Mise au point. Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale. 2015 Sep;116(4):201–8.

Valente VB, Kayahara GM, Miyahara GI, Biasoli ÉR, Bernabé DG. Diagnosis and Treatment of Oral Venous Malformation in a Child. Journal of Craniofacial Surgery. 2020 Jun;31(4):e393–4.

Sitra G, Sivasankari T, Vishwanath R, Kayalvizhi E. A new venture with sclerotherapy in an oral vascular lesion. Journal of Basic and Clinical Pharmacy. 2015;6(1):40.

Bhatnagar A, Upadhyaya VD, Kumar B, Neyaz Z, Kushwaha A. Aqueous intralesional bleomycin sclerotherapy in lymphatic malformation: Our experience with children and adult. National Journal of Maxillofacial Surgery [Internet]. 2017 Jul 1 [cited 2021 Nov 2];8(2):130–5.

Li J, Chen J, Zheng G, Liao G, Fu Z, Li J, et al. Digital Subtraction Angiography-Guided Percutaneous Sclerotherapy of Venous Malformations With Pingyangmycin and/or Absolute Ethanol in the Maxillofacial Region. Journal of Oral and Maxillofacial Surgery. 2010 Sep;68(9):2258–66.

Liu Y, Liu D, Wang Y, Zhang W, Zhao F. Clinical Study of Sclerotherapy of Maxillofacial Venous Malformation Using Absolute Ethanol and Pingyangmycin. Journal of Oral and Maxillofacial Surgery. 2009 Jan;67(1):98–104.

Hoque S, Das BK. Treatment of venous malformations with ethanolamine oleate: a descriptive study of 83 cases. Pediatric Surgery International. 2011 Feb 3;27(5):527–31.

Kuo H-W, Yang C-H. Venous Lake of the Lip Treated With a Sclerosing Agent: Report of Two Cases. Dermatologic Surgery. 2003 Apr;29(4):425–8.

Zhang W, Chen G, Ren J-G, Zhao Y-F. Bleomycin induces endothelial mesenchymal transition through activation of mTOR pathway: a possible mechanism contributing to the sclerotherapy of venous malformations. British Journal of Pharmacology. 2013 Oct 28;170(6):1210–20.

Zhao J-H, Zhang W-F, Zhao Y-F. Sclerotherapy of oral and facial venous malformations with use of pingyangmycin and/or sodium morrhuate. International Journal of Oral and Maxillofacial Surgery. 2004 Jul;33(5):463–6.

de Queiroz SBF, de Lima VN, Amorim PHGH, Statkievicz C, Magro-Filho O. Severe Edema After Sclerotherapy of Labial Hemangioma With Ethamolin Oleate in a Young Child. Journal of Craniofacial Surgery. 2016 Sep;27(6):e567–8.

Hoffman K. An Unusual Complication of Facial Sclerotherapy. Dermatologic Surgery. 2003 Apr;29(4):423–4.

Kuhn-Dall’Magro A, Farenzena KP, Blum D, Vicari T, Pauletti R, Maldaner G. O uso do oleoato de etanolamina na escleroterapia de lesões vasculares da região maxilofacial: revisão de literatura e relatos de casos. Revista da Faculdade de Odontologia - UPF [Internet]. 2012 Jul 17 [cited 2022 Jan 25];17(1).

PALMA FR. Escleroterapia de hemangioma oral. Relato de caso. SALUSVITA. 2016 Apr 4;35(1):85.

HONG S-K, LEE H-J, SEO J-K, LEE D, HWANG S-W, SUNG H-S. Reactive Vascular Lesions Treated Using Ethanolamine Oleate Sclerotherapy. Dermatologic Surgery. 2010 Jul;36(7):1148–52.

ROSA, W. A. F. D.; DE OLIVEIRA JUNIOR, C. B.; DE CARVALHO, D. F.; NESPOLO, R. C. E.; GOTTARDO, V. D.; QUEIROZ, P. M. Escleroterapia como conduta conservadora no tratamento de malformação vascular oral: relato de caso clínico. Brazilian Journal of Health Review, [S. l.], v. 6, n. 5, p. 25885–25897, 2023. DOI: 10.34119/bjhrv6n5-573.

Biagiote, J. C. de S., Santo, J. R. S. do E., Rios, R. da S., da Nóbrega, F. S. G., Nunes, B. M. M. B., Nogueira Filho, L. L. T., Nogueira, P. T. B. de C., & Gonçalves, E. de G. (2022). Escleroterapia de hemangioma em lábio inferior: relato de caso: Sclerotherapy of hemangioma in the lower lip: case report. Brazilian Journal of Development, 8(8), 57199–57207. https://doi.org/10.34117/bjdv8n8-156

Published

04/22/2024

How to Cite

ROCHA, L. de L. R.; PEIXOTO, A. C. C.; HENRIQUES, J. C. G.; ZANCOPÉ, K. Diferentes tipos e protocolos de esclerosantes vasculares no tratamento das má formações vasculares orais: revisão literária. Brazilian Journal of Health Review, [S. l.], v. 7, n. 2, p. e69117, 2024. DOI: 10.34119/bjhrv7n2-424. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/69117. Acesso em: 25 oct. 2026.

Issue

Section

Original Papers