Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia

Authors

  • Anacleto Braga Barroso Filho
  • Layene Ariely de Oliveira Barros
  • Karla Rivellyne de Castro Ribeiro
  • Cesar Augusto da Silva
  • Bruna Del Vechio Koike

DOI:

https://doi.org/10.34119/bjhrv7n2-323

Keywords:

kombucha, diabetes, cholesterol

Abstract

Diabetes is one of the most common comorbidities in the world. The scientific community is constantly looking for therapeutic alternatives, pharmacological or not, to treat this disease. In this concern, an integrative review of studies published on this topic in the last ten years was carried out. Experimental studies have shown glycemic and lipid rates reduction in diabetic guinea pigs under daily kombucha consumption. Such studies showed blood sugar levels reduction of up to 56% of these specimens, as well as a significant reduction of free radicals, hepatoprotection and reduction of transaminases in these animals.

References

ABACI, N.; SENOL DENIZ, F. S.; ORHAN, I. E. Kombucha – An ancient fermented beverage with desired bioactivities: A narrowed review. Food Chemistry: X, jun. 2022. v. 14, p. 100302. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S2590157522001006>.

ALAEI, Z.; DOUDI, M.; SETORKI, M. The protective role of Kombucha extract on the normal intestinal microflora, high-cholesterol diet caused hypercholesterolemia, and histological structures changes in New Zealand white rabbit. Avicenna J Phytomed, 2020. v. 10, p. 604–614.

ALOULOU, A. et al. Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats. BMC Complementary and Alternative Medicine, 2012.

AMERICAN DIABETES ASSOCIATION - ADA. Standards of Medical Care in Diabetes—2019 Abridged for Primary Care Providers. Clinical Diabetes, 1 jan. 2019. v. 37, n. 1, p. 11–34. Disponível em: <https://diabetesjournals.org/clinical/article/37/1/11/32671/Standards-of-Medical-Care-in-Diabetes-2019>.

ANHÊ, F. F. et al. Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity. Nature Metabolism, 9 mar. 2020. v. 2, n. 3, p. 233–242. Disponível em: <https://www.nature.com/articles/s42255-020-0178-9>.

AOKI, R. et al. A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation. Scientific Reports, 2 mar. 2017. v. 7, n. 1, p. 43522. Disponível em: <https://www.nature.com/articles/srep43522>.

BARBOZA, A. A. A. et al. Consumption of functional foods and their benefits in type II diabetes mellitus: literature review. Research, Society and Development, 2020. Disponível em: <https://rsdjournal.org/index.php/rsd/article/view/7058. Acesso em: 1 jun. 2021.>.

BELLASSOUED, K. et al. Protective effect of kombucha on rats fed a hypercholesterolemic diet is mediated by its antioxidant activity. Pharmaceutical Biology, 2 nov. 2015. v. 53, n. 11, p. 1699–1709. Disponível em: <http://www.tandfonline.com/doi/full/10.3109/13880209.2014.1001408>.

BELLO, A.; FALLER, A. L. K. Nutrição e Destoxificação – Bases Moleculares para a Prática Clínica. 1. ed. ed. Rio de Janeiro: Rubio, 2016.

BHATTACHARYA, S.; GACHHUI, R.; SIL, P. C. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food and Chemical Toxicology, 2013. v. 60, p. 328–340.

BIANCHI, M. De L. P.; ANTUNES, L. M. G. Radicais livres e os principais antioxidantes da dieta. Revista de Nutrição, ago. 1999. v. 12, n. 2, p. 123–130. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52731999000200001&lng=pt&tlng=pt>.

CARDOSO, R. R. et al. Kombuchas from green and black teas reduce oxidative stress, liver steatosis and inflammation, and improve glucose metabolism in Wistar rats fed a high-fat high-fructose diet. Food & Function, 2021. v. 12, n. 21, p. 10813–10827. Disponível em: <http://xlink.rsc.org/?DOI=D1FO02106K>.

COTON, M. et al. Unraveling microbial ecology of industrial-scale Kombucha fermentations by metabarcoding and culture-based methods. 2017. n. April, p. 1–16.

DIMIDI, E. et al. Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease. Nutrients, 5 ago. 2019. v. 11, n. 8, p. 1806. Disponível em: <https://www.mdpi.com/2072-6643/11/8/1806>.

DIPTI, P. et al. Lead induced oxidative stress: beneficial effects of Kombucha tea. Biomed Environ Sci, 2003. v. 16, n. 3, p. 276–282.

FERNANDES, N. P. et al. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complementary and Alternative Medicine, 24 dez. 2007. v. 7, n. 1, p. 29. Disponível em: <https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-7-29>.

FILIPPIS, F. DE et al. Different temperatures select distinctive acetic acid bacteria species and promotes organic acids production during Kombucha tea fermentation. Food Microbiology, ago. 2018. v. 73, p. 11–16. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S0740002017306937>.

FU, C. et al. Antioxidant activities of kombucha prepared from three different substrates and changes in content of probiotics during storage. Food Science and Technology, 25 mar. 2014. v. 34, n. 1, p. 123–126. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612014000100018&lng=en&tlng=en>.

GAGGÌA, F. et al. Kombucha Beverage from Green, Black and Rooibos Teas: A Comparative Study Looking at Microbiology, Chemistry and Antioxidant Activity. Nutrients, 20 dez. 2018. v. 11, n. 1, p. 1. Disponível em: <http://www.mdpi.com/2072-6643/11/1/1>.

GARCIMART, A.; BENED, J. Whole Alga , Algal Extracts , and Compounds as Ingredients of Functional Foods : Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus. 2021.

GONZÁLEZ ARBELÁEZ, L. F. et al. Cardioprotection and natural polyphenols: an update of clinical and experimental studies. Food & Function, 2018. v. 9, n. 12, p. 6129–6145. Disponível em: <http://xlink.rsc.org/?DOI=C8FO01307A>.

GOSZCZ, K. et al. Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response? British Journal of Pharmacology, jun. 2017. v. 174, n. 11, p. 1209–1225. Disponível em: <https://onlinelibrary.wiley.com/doi/10.1111/bph.13708>.

HU, S. et al. Fucoidan from Acaudina molpadioides improves insulin resistance by altering gut microbiota dysfunction. Journal of Functional Foods, jun. 2019. v. 57, p. 59–67. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S1756464619301550>.

IATCU, C. O.; STEEN, A.; COVASA, M. Gut Microbiota and Complications of Type-2 Diabetes. Nutrients, 30 dez. 2021. v. 14, n. 1, p. 166. Disponível em: <https://www.mdpi.com/2072-6643/14/1/166>.

JAYABALAN, Rasu et al. A Review on Kombucha Tea — Microbiology , Composition , Fermentation , Beneficial Effects , Toxicity , and Tea Fungus. 2014. v. 13.

KAPP, J. M.; SUMNER, W. Kombucha : a systematic review of the empirical evidence of human health benefit. Annals of Epidemiology, 2019. v. 30, p. 66–70. Disponível em: <https://doi.org/10.1016/j.annepidem.2018.11.001>.

KLONOFF, D. C. United Kingdom Prospective Diabetes Study Follow-Up Studies Establish a Legacy Effect of Therapy for Hyperglycemia but Not Hypertension. 2008. v. 2, n. 6, p. 922–924.

KOVACEVIC, Z. et al. A Toxic Hepatitis Caused the Kombucha Tea – Case Report. Macedonian Journal of Medical Sciences, 15 mar. 2014. v. 7, n. 1. Disponível em: <http://www.mjms.mk/Online/MJMS_2014_7_1/MJMS.1857-5773.2013-0341.pdf>.

KUMAR, V.; JOSHI, V. K. Kombucha : Technology, Microbiology, Production, Composition and Therapeutic Value. International Journal of Food and Fermentation Technology, 2016. v. 6, n. 1, p. 13. Disponível em: <http://www.indianjournals.com/ijor.aspx?target=ijor:ijfft&volume=6&issue=1&article=002>.

LAUREYS, D.; BRITTON, S. J.; CLIPPELEER, J. De. The Science of Beer Kombucha Tea Fermentation : A Review. Journal of the American Society of Brewing Chemists, 2020. v. 0, n. 0, p. 1–10. Disponível em: <https://doi.org/10.1080/03610470.2020.1734150>.

LI, Y. et al. Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity. The Journal of Nutritional Biochemistry, abr. 2020. v. 78, p. 108324. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S0955286319302748>.

MARTÍNEZ LEAL, J. et al. A review on health benefits of kombucha nutritional compounds and metabolites. CyTA - Journal of Food, 12 jan. 2018. v. 16, n. 1, p. 390–399. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/19476337.2017.1410499>.

MELLO, T.; MATEROZZI, M.; GALLI, A. PPARs and Mitochondrial Metabolism: From NAFLD to HCC. PPAR Research, 2016. v. 2016, p. 1–18. Disponível em: <https://www.hindawi.com/journals/ppar/2016/7403230/>.

MENEZES, C. A. G. P. et al. Microbiota intestinal e a intrínseca relação com a Doença de Parkinson. Brazilian Journal of Health Review, 4 mar. 2024. v. 7, n. 2, p. e67782. Disponível em: <https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/67782>.

MOREIRA, G. V. et al. Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice. Biomedicine & Pharmacotherapy, nov. 2022. v. 155, p. 113660. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S0753332222010496>.

MUKHERJEE, P.; VENKATESH, P.; PONNUSANKAR, S. Ethnopharmacology and integrative medicine - Let the history tell the future. Journal of Ayurveda and Integrative Medicine, 2010. v. 1, n. 2, p. 100. Disponível em: <http://www.jaim.in/text.asp?2010/1/2/100/65077>.

MURUGESAN, G. S. et al. Hepatoprotective and curative properties of Kombucha tea against Carbon tetrachloride-induced toxicity. Journal of Microbiology and Biotechnology, 2009. v. 19, n. 4, p. 397–402.

NAKAI, M. et al. Inhibitory Effects of Oolong Tea Polyphenols on Pancreatic Lipase in Vitro. J Agric Food Chem, 2005. v. 53, n. 11, p. 4593–4598.

PERMATASARI, H. K. et al. Kombucha drink enriched with sea grapes (Caulerpa racemosa) as potential functional beverage to contrast obesity: An in vivo and in vitro approach. Clinical Nutrition ESPEN, jun. 2022. v. 49, p. 232–240. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S2405457722002406>.

RAO, N. K.; NAMMI, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine, 7 dez. 2006. v. 6, n. 1, p. 17. Disponível em: <https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-6-17>.

SAAD, S. M. I. Probióticos e prebióticos: o estado da arte. Revista Brasileira de Ciências Farmacêuticas, mar. 2006. v. 42, n. 1, p. 1–16. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-93322006000100002&lng=pt&nrm=iso&tlng=pt>.

SANNA, S. et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics, 18 abr. 2019. v. 51, n. 4, p. 600–605. Disponível em: <https://www.nature.com/articles/s41588-019-0350-x>.

SHARMA, S.; TRIPATHI, P. Gut microbiome and type 2 diabetes: where we are and where to go? The Journal of Nutritional Biochemistry, jan. 2019. v. 63, p. 101–108. Disponível em: <https://linkinghub.elsevier.com/retrieve/pii/S0955286318303073>.

STASIAK, L.; BŁAEJAK, S. Acetic acid bacteria-perspectives of application in biotechnology-a review. Polish Journal of Food and Nutrition Sciences, 2009. v. 59, n. 1, p. 17–23.

SUFFI, N. et al. Resveratrol acts as an antioxidant in leukocytes of patients with diabetes mellitus 2 through the AMPK signaling pathway. Brazilian Journal of Health Review, 11 mar. 2024. v. 7, n. 2, p. e67982. Disponível em: <https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/67982>.

VENKATAKRISHNAN, K. et al. Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea in a double-blind clinical trial. Food & Function, 2018. v. 9, n. 2, p. 1205–1213. Disponível em: <http://xlink.rsc.org/?DOI=C7FO01449J>.

VINA, I. et al. Current evidence on physiological activity and expected health effects of kombucha fermented beverage. Journal of Medicinal Food, 1 fev. 2014. v. 17, n. 2, p. 179–188.

VĪNA, I. et al. Glucuronic acid from fermented beverages: biochemical functions in humans and its role in health protection. Ijrras, 2013. v. 14, n. 2, p. 217–230. Disponível em: .

WATAWANA, M. I. et al. Health, Wellness, and Safety Aspects of the Consumption of Kombucha. Journal of Chemistry, 2015. v. 2015, p. 1–11. Disponível em: <http://www.hindawi.com/journals/jchem/2015/591869/>.

WU, G. D. et al. Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes. Science, 7 out. 2011. v. 334, n. 6052, p. 105–108. Disponível em: <https://www.science.org/doi/10.1126/science.1208344>.

XU, S. et al. Kombucha Reduces Hyperglycemia in Type 2 Diabetes of Mice by Regulating Gut Microbiota and Its Metabolites. Foods, 5 mar. 2022. v. 11, n. 5, p. 754. Disponível em: <https://www.mdpi.com/2304-8158/11/5/754>.

YANG, Z.-W. et al. Hypocholesterolaemic and antioxidant effects of kombucha tea in high-cholesterol fed mice. Journal of the Science of Food and Agriculture, 15 jan. 2009. v. 89, n. 1, p. 150–156. Disponível em: <https://onlinelibrary.wiley.com/doi/10.1002/jsfa.3422>.

YAVARI, N. et al. Glucuronic Acid Rich Kombucha-fermented Pomegranate Juice. Journal of Food Research, 24 dez. 2017. v. 7, n. 1, p. 61. Disponível em: <http://www.ccsenet.org/journal/index.php/jfr/article/view/64447>.

Published

04/10/2024

How to Cite

BARROSO FILHO, A. B.; BARROS, L. A. de O.; RIBEIRO, K. R. de C.; SILVA, C. A. da; KOIKE, B. D. V. Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia. Brazilian Journal of Health Review, [S. l.], v. 7, n. 2, p. e68785, 2024. DOI: 10.34119/bjhrv7n2-323. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/68785. Acesso em: 18 oct. 2026.

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Section

Original Papers