Atualização em criopreservação de tecido ovariano / Update on ovarian tissue criopreservation
Keywords:Criopreservação. Tecido ovariano. Transplante. Preservação da fertilidade. Oncofertilidade.
A taxa de mulheres que estão recorrendo às técnicas de reprodução assistida para a concepção cresce a cada ano. Um dos fatores que ratifica esse aumento é o fato de as mulheres estarem postergando a primeira gestação para depois dos 30 anos, logo quando inicia um acentuado declínio na fertilidade, outro fator que causa infertilidade são as neoplasias. Uma das soluções para preservação da fertilidade em pacientes com neoplasias e para preservação social é a criopreservação tecido ovariano (CTO). O objetivo deste artigo é identificar, por meio da revisão da literatura, a utilização do método de CTO como uma alternativa terapêutica para a preservação da fertilidade feminina. Foram selecionados artigos experimentais em inglês, português e espanhol nos bancos de dados PubMed, Cochrane Library e ScienceDirect, que realizaram a criopreservação de tecido ovariano entre 2014 e 2019. De 38 artigos selecionados, 18 com 1.332 pacientes relataram 199 gestações e 164 nascidos vivos. Dos 18 artigos, 88,8% foi reimplantado de maneira ortotópica e 11,1% heterotópica. Assim, CTO pode ser utilizada em pacientes pré e pós-púberes, não necessita de parceiros nem de estimulação ovariana, existindo grandes possibilidades de restauração endócrina e gravidez natural.
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