Capacidade de sobrevivência em diferentes meios e incidência de infecções hospitalares por Pseudomonas aeruginosa
DOI:
https://doi.org/10.34119/bjhrv7n2-069Keywords:
Pseudomonas aeruginosa, super-resistência, infecção nosocomialAbstract
A bactéria Pseudomonas aeruginosa é responsável por diversas doenças infecto contagiosas que acarretam no óbito de milhões de hospitalizados ao redor do mundo, estes que são facilmente colonizados devido a portabilidade de comorbidades. A P. aeruginosa é uma das principais causas que dificultam o tratamento desses pacientes, visto que, esse microrganismo conta com variados mecanismos e estruturas de virulência e super resistência bacteriana. Tais características permitem a permanência da P. aeruginosa em ambientes desfavoráveis para o seu crescimento. Objetivo: Correlacionar as capacidades de sobrevivência da P. aeruginosa com a incidência de infecções hospitalares. Metodologia: Revisão narrativa incluindo artigos das bases de dados do Pubmed, Scielo, Lancet, Nature, NCBI, Science direct, Taylor e Francis Online e o google acadêmico. Foram escolhidos os trabalhos que abordaram ao menos um dos principais tópicos da revisão, sendo eles, estruturas de super resistência bacteriana, estruturas de virulência, consumo de fontes de carbono, infecções hospitalares e tempo de sobrevivência em diferentes ambientes. Resultados: Com base neste estudo fica evidente que ocorre uma clara correlação entre as capacidades de sobrevivência e virulência da P. aeruginosa com a incidência de infecções hospitalares.
References
VERFAILLIE, Charlotte et al. “Withdrawal of a novel-design duodenoscope ends outbreak of a VIM-2-producing Pseudomonas aeruginosa.” Endoscopy 2015; vol. 47 (6): 493-502.
BUSH, larry. Infecções por Pseudomonas. 2022 Disponível em: <https://www.msdmanuals.com/pt-br/casa/infec%C3%A7%C3%B5es/infec%C3%A7%C3%B5es-bacterianas-bact%C3%A9rias-gram-negativas/infec%C3%A7%C3%B5es-por-pseudomonas>.
BERROUANE, Y F et al. “Outbreak of severe Pseudomonas aeruginosa infections caused by a contaminated drain in a whirlpool bathtub.” Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000; 31(6): 1331-7.
SILVA et al. Características microbiológicas e perfil de resistência de microrganismos causadores de infecções hospitalar em uma UTI para pacientes pediátricos de um hospital referência em infectologia do Amazonas. BJHR. 2020;3(4):8663–78.
YETKIN, Gulay et al. “Clinical, microbiologic, and epidemiologic characteristics of Pseudomonas aeruginosa infections in a University Hospital, Malatya, Turkey.” American journal of infection control 2006; 34(4): 188-92.
SALERIAN, Alen J. “Burn wound infections and Pseudomonas aeruginosa.” Burns : journal of the International Society for Burn Injuries 2020; 46(1): 257-258.
KERR, KG, and Snelling, AM. “Pseudomonas aeruginosa: a formidable and ever-present adversary.” The Journal of hospital infection 2009; 73(4): 338-44.
POLLACK, M. The Virulence of Pseudomonas aeruginosa. Clinical Infectious Diseases 1984; 6(3): 617-26.
LOUREIRO, RJ et al; O uso de antibióticos e as resistências bacterianas: breves notas sobre a sua evolução. Revista portuguesa de saúde pública 2016; 34(1): 77-84.
GUIMARÃES L, SUSANA P; MO, I.; PEREIRA, M. O., The antimicrobial action of Pseudomonas aeruginosa byproducts in the control of single and mixed biofilms. Semana de Engenharia 2010.
BERROUANE, Y F et al. “Outbreak of severe Pseudomonas aeruginosa infections caused by a contaminated drain in a whirlpool bathtub.” Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000; 31(6): 1331-7.
LIVERMORE, david. Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?. Clinical Infectious Diseases 2002; 34(5): 634-40.
MANDELL, G. L.; BENNETT, J. E.; DOLIN, R. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases 7th edition. 2000.
HOFMANN, Lukas et al. “Advances in Understanding of the Copper Homeostasis in Pseudomonas aeruginosa.” International journal of molecular sciences 2021; 22(4): 2050.
BUSH K., JACOBY G.A. Updated functional classification of betalactamases. Antimicrob. Agents Chemother. 2010; 54:969–976.
TROUILLET, J L et al. “Pseudomonas aeruginosa ventilator-associated pneumonia: comparison of episodes due to piperacillin-resistant versus piperacillin-susceptible organisms.” Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002; 34(8): 1047-54.
Aliberti S, Dela Cruz CS, Amati F, Sotgiu G, Restrepo MI. Community-acquired pneumonia. Lancet. 2021 Sep 4;398(10303):906-919. doi: 10.1016/S0140-6736(21)00630-9. PMID: 34481570.
CDC. Antibiotic Resistance Threats in the United States. Atlanta, Department of Health and Human Services. 2019.
TRIBUNAL DE CONTAS EUROPEU. Atuação contra a resistência antimicrobiana: apesar dos progressos no setor animal, esta ameaça para a saúde continua a ser um desafio para a UE. Luxemburgo, 2019.
OMS. Antimicrobial Resistance. 2019. Disponível em: <https://www.who.int>. Acesso em: 19 de set.
LANCET. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. 2022. v. 399, p. 629–655.
TACCONELLI et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018. v. 3, p. 318–27.
PANG et al. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnology Advances. 2019. v. 37, p. 177-192.
BURNS et al. Avaliação longitudinal de Pseudomonas aeruginosa em crianças pequenas com fibrose cística. 2001. v. 183, p. 444-452.
EMERSON et al. Pseudomonas Aeruginosa and Other Predictors of Mortality and Morbidity in Young Children With Cystic Fibrosis. 2002. v. 34. p. 91-100.
HOLZMANN et al. Effects of sinus surgery in patients with cystic fibrosis after lung transplantation: A 10-Year Experience. v. 77. 2004. p. 134-136.
LARI, A. R.; ALAGHEHBANDAN, R. Nosocomial infections in an Iranian burn care center. 2000 v. 26, p. 737-740.
EROL et al. Changes of microbial flora and wound colonization in burned patients. 2004. v. 30, p. 357–361.
SONG et al. Microbiologic aspects of predominant bacteria isolated from the burn patients in Korea. 2001. v. 27, p. 136–139.
TANEJA et al. A prospective study of hospital-acquired infections in burn patients at a tertiary care referral centre in North India. 2004. v. 30, p. 665–669.
AFESSA et al. Bacterial Pneumonia in Hospitalized Patients With HIV Infection: The Pulmonary Complications, ICU Support, and Prognostic Factors of Hospitalized Patients With HIV (PIP) Study. 2000. v. 117, p. 1017-1022.
PAVIANI, E. R.; STADNIK, C. B.; HEINEK, I. Estudo da Epidemiologia e Perfil de Sensibilidade da Pseudomonas aeruginosa. 2004. v. 15, p. 11-12.
TORTORA, G. J.; FUNKE, B.R.; CASE, C. L. MICROBIOLOGIA. 2017. 12°edição. Porto Alegre: Artmed.
RODRIGUES et al. Perfil e sensibilidade antimicrobiana de bactérias em cultura de pacientes com pneumonia associada à ventilação mecânica durante a pandemia COVID-19: uma revisão integrativa. Braz J Hea Rev. 27 de novembro de 2023;6(6):29595–614.
LAU et al. The role of pyocyanin in Pseudomonas aeruginosa infection. 2004. ELSEVIER. v. 10, p. 599-606.
FALK et al.Outbreak of Vancomycin‐Resistant Enterococci in a Burn Unit. 2000. v. 21, p. 575-582.
LEVIN et al. Contamination of Portable Radiograph Equipment With Resistant Bacteria in the ICU. 2009. v. 136, p. 426 –432.
MULLANEY et al. How clean is your probe? Microbiological assessment of ultrasound transducers in routine clinical use, and cost-effective ways to reduce contamination. 2007. v. 62, p. 694-698.
RUSSOTTO et al. Bacterial contamination of inanimate surfaces and equipment in the intensive care unit. 2015 v. 3, p. 46-54.
KRAMER, A.; SCHWEBKE, I.; KAMPF, G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BioMed Central. 2006.
ZAHORNACKÝ et al. Gram-Negative Rods on Inanimate Surfaces of Selected Hospital Facilities and Their Nosocomial Significance. Int J Environ Res Public Health. 2022. v. 10.
KARASH, S.; YAHR, T. L. Genome-Wide Identification of Pseudomonas aeruginosa Genes Important for Desiccation Tolerance on Inanimate Surfaces. mSystems. 2022. v. 2.
WIBMANN et al. Persistence of Pathogens on Inanimate Surfaces: A Narrative Review. Microorganisms. 2021. v. 2.
NEELY, alice. A survey of gram-negative bacteria survival on hospital fabrics and plastics. 2000. v. 21, p. 523-527.
HANCZVIKKEL, A.; TÓTH, Á. Quantitative study about the role of environmental conditions in the survival capability of multidrug-resistant bacteria. J Infect Public Health. 2018. v. 6, p. 801–806.
ZHANG et al. Construction of antibacterial surface via layer-by-layer method. Curr Pharm Des. 2018 v. 8, p. 926–35.
PETERSON et al. Portable UV light as an alternative for decontamination. Am J Infect Control. 2014. v. 12, p. 1334–1336.
NAGATA et al. Effects of storage temperature, storage time, and Cary-Blair transport medium on the stability of the gut microbiota. Drug Discov Ther. 2019. v. 5, p. 256–260.
SHIMODA et al. Effect of thermal control of dry fomites on regulating the survival of human pathogenic bacteria responsible for nosocomial infections. PLoS ONE. 2019. v. 12.
KATZENBERGER, R. H.; RöSEL, A.; VONBERG, R. P. Bacterial survival on inanimate surfaces: a field study. BMC Res Notes. 2021. v. 1.
MATZ et al. Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae. 2008. v. 2, p. 843–852.
TART, A. H.; WOZNIAK, D. J.; Shifting Paradigms in Pseudomonas aeruginosa Biofilm Research. 2008. v. 328, p. 193-206.
ARAI, hiroyuki. Regulation and function of versatile aerobic and anaerobic respiratory metabolism in Pseudomonas aeruginosa. 2011. v. 2.
MCMACKIN et al. Fitting pieces into the puzzle of Pseudomonas aeruginosa Type III secretion system gene expression. J bacteriol. 2019 v. 13.
World Health Organization. Prioritization of Pathogens to Guide Discovery, Research and Development of New Antibiotics for Drug-Resistant Bacterial Infections, Including Tuberculosis. World Health Organization: Geneva, Switzerland, 2017.
SPELLBERG, B.; GUIDOS, R.; GILBERT, D. The epidemic of antibiotic-resistant infections: A call to action for the medical community from the Infectious Diseases Society of America. Clin. Infect. Dis. 2008. v. 46, p. 155–164.
MANOUKIAN et al. Estimating excess length of stay due to healthcare-associated infections: A systematic review and metaanalysis of statistical methodology. J. Hosp.Infect. 2018. v. 100, p. 222–235.
PANASIA et al. Sulfate Ester Detergent Degradation in Pseudomonas aeruginosa Is Subject to both Positive and Negative Regulation.2019. v. 85.
LI, X. Z; ZHANG, L.; POOLE, K. Interplay between the MexA–MexB–OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa. J Antimicrob Chemother. 2000. v. 45, p. 433–436.
FIT. HPAs - Hidrocarbonetos Policíclicos Aromáticos. 2022. Disponível em: <https://cetesb.sp.gov.br/laboratorios/wp-content/uploads/sites/24/2018/07/HPAs-Hidrocarbonetos-Polic%C3%ADclicos-Arom%C3%A1ticos.pdf>. Acesso em: 1 de set.
SUETENS et al. Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: Results from two european point prevalence surveys, 2016 to 2017. Eurosurveillance. 2018. v. 23.
JOSHI et al. Nosocomial infection: Source and prevention. Int. J. Pharm. Sci. Res. 2019. v. 10, p. 1613–1624.
SALMANOV et al. Evaluation Of Bacterial Contamination In The Inanimate Environment Surfaces In Acute Care Hospitals In Kyiv, Ukraine. Wiad Lek. 2022. v. 2, p. 483-489.
SULEYMAN, G.; ALANGADEN, G.; BARDOSSY, A. C. The role of environmental contamination in the transmission of nosocomial pathogens and healthcare associated infections. Curr Infect Dis Rep. 2018. v. 6.
OTTER, J. A.; YEZLI, S.; FRENCH, G. L. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol. 2011. v. 7, p. 687–99.
BURES et al. Computer keyboards and faucet handles as reservoirs of nosocomial pathogens in the intensive care unit. American Journal of Infection Control. 2000. v. 28, p. 465-471.
FERRONI et al. Bacterial contamination in the environment of hospitalised children with cystic fibrosis. J. Cyst. Fibros. 2008. v. 6, p. 477-482.
LEMMEM et al. Distribution of multi-resistant Gram-negative versus Gram-positive bacteria in the hospital inanimate environment. Journal of Hospital Infection. 2004. v. 56, p. 191-197.
LING et al. A nosocomial outbreak of multiresistant Acinetobacter baumannii originating from an intensive care unit. Infection Control and Hospital Epidemiology. 2001. v. 22, p. 48-49.
HANNA et al. Control of nosocomial Clostridium difficile transmission in bone marrow transplant patients. Infection Control and Hospital Epidemiology. 2000. v. 21, p. 226-228.
FITZPATRICK et al. A purpose built MRSA cohort study. Journal of Hospital Infection. 2000. v. 46, p. 271-279.
LALAMI et al. Microbiological monitoring of environment surfaces in a hospital in Fez city, Morocco surveillance microbiologique des surfaces de l’ environnement d’ un hôpital dans la ville de Fès, au Maroc. J. Mater. Environ. Sci. 2016. v. 7, p. 123–130.
TRUONG et al. Synergistic antibacterial activity of silver-loaded graphene oxide towards Staphylococcus Aureus and Escherichia Coli. Nanomaterials. 2020. v. 2.
DAUVERGNE et al. Validation of a worst-case scenario method adapted to the healthcare environment for testing the antibacterial efect of brass surfaces and implementation on hospital antibiotic-resistant strains. Antibiotics (Basel). 2020. v. 5.
PETERSON et al. Portable UV light as an alternative for decontamination. Am J Infect Control. 2014. v. 12, p. 1334–1336.
CASELLI et al. An innovative strategy for the efective reduction of MDR pathogens from the nosocomial environment. Adv Exp Med Biol. 2019. v. 1214, p. 79–91.
DECRAENE et al. An outbreak of multidrug-resistant Pseudomonas aeruginosa in a burns service in the North of England: challenges of infection prevention and control in a complex setting. Journal of Hospital Infection. 2018. v. 4, p. 1-7.
