Polimorfismos nos genes CCDC122-LACC1 e IL23R e a hanseníase
DOI:
https://doi.org/10.34119/bjhrv7n1-040Keywords:
polimorfismos, CCDC122-LACC1, IL23R, genética humana e médicaAbstract
A hanseníase é uma doença infecciosa e contagiosa, de origem milenar. Os fatores genéticos podem influenciar no desenvolvimento da doença, como os SNPs em genes envolvidos na resposta imune frente à infecção. Dentre esses genes, têm-se CCDC122-LACC1 e IL23R. O objetivo deste estudo foi realizar uma revisão integrativa abordando os SNPs desses genes e a associação com a hanseníase. Foi realizada uma revisão integrativa incluindo estudos de associação entre polimorfismos dos genes estudados e a hanseníase, entre 2009-2021. As bases de dados utilizadas foram PubMed Central NCBI, Google Scholar e MEDLINE. Os estudos selecionados foram filtrados com critérios de inclusão e exclusão previamente estabelecidos. A pesquisa realizada incluiu quatorze estudos para a revisão integrativa. O gene CCDC122-LACC1, apresentou o rs9533634, que foi associado à proteção nas populações indianas e africanas. Já o gene IL23R, apresentou os SNPs rs3762318 e rs2144658 associados à proteção à hanseníase nos chineses. Este estudo forneceu uma visão geral sobre a associação entre os genes CCDC122-LACC1 e IL23R, e a hanseníase, sugerindo que estes podem desempenhar um papel importante na resposta imune à doença.
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