Vitamina D e neuropatia periférica diabética - uma revisão integrativa
DOI:
https://doi.org/10.34119/bjhrv6n6-456Keywords:
neuropatia periférica, neuropatia periférica diabética, neuropatia diabética, diabetes tipo 2, vitamina D, deficiência de vitamina DAbstract
Introdução: A Neuropatia Periférica Diabética é a complicação mais comum em pacientes com Diabetes mellitus tipo 2, estando presente em mais de 50% dos diabéticos. Ainda, a deficiência de vitamina D é muito prevalente em pacientes com Diabetes mellitus tipo 2. Em vista disso, o presente estudo tem como objetivo realizar uma revisão integrativa da literatura acerca da relação entre vitamina D e neuropatia periférica diabética. Materiais e Métodos: Foi realizada uma revisão de literatura nas plataformas PUBMED (US National Library of Medicine), EMBASE, SCIELO (Scientific Eletronic Library), SCOPUS e LILACS no período de janeiro/2011 a dezembro/2022. Foram encontrados 623 artigos, dos quais 25 foram incluídos. Resultados: Os níveis séricos de vitamina D foram menores nos pacientes com Neuropatia Periférica Diabética. Ainda, os grupos classificados como deficientes/insuficientes em vitamina D esteve relacionado com maior prevalência de Neuropatia Periférica Diabética em comparação aos indivíduos com níveis suficientes de vitamina D. Conclusão: A maioria dos estudos demonstrou correlação positiva entre deficiência/insuficiência de vitamina D e Neuropatia Periférica Diabética. A vitamina D pode ser considerada um fator de risco para a Neuropatia Periférica Diabética, independente de outros fatores já conhecidos, e deve ter seus níveis rotineiramente mensurados para pacientes diabéticos.
References
Butler AE, Dargham SR, Latif A, Mokhtar HR, Robay A, Chidiac OM, Jayyousi A, Al Suwaidi J, Crystal RG, Abi Khalil C, Atkin SL. Association of vitamin D3 and its metabolites in patients with and without type 2 diabetes and their relationship to diabetes complications. Ther Adv Chronic Dis. 2020 Sep 26;11:2040622320924159. doi: 10.1177/2040622320924159.
Ahmed LHM, Butler AE, Dargham SR, Latif A, Chidiac OM, Atkin SL, Abi Khalil C. Vitamin D3 metabolite ratio as an indicator of vitamin D status and its association with diabetes complications. BMC Endocr Disord. 2020 Oct 27;20(1):161. doi: 10.1186/s12902-020-00641-1.
Esteghamati A, Fotouhi A, Faghihi-Kashani S, Hafezi-Nejad N, Heidari B, Sheikhbahaei S, Zandieh A, Nakhjavani M. Non-linear contribution of serum vitamin D to symptomatic diabetic neuropathy: A case-control study. Diabetes Res Clin Pract. 2016 Jan;111:44-50. doi: 10.1016/j.diabres.2015.10.018.
Soderstrom LH, Johnson SP, Diaz VA, Mainous AG 3rd. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med. 2012 Jan;29(1):50-5. doi: 10.1111/j.1464-5491.2011.03379.x.
Yammine K, Wehbe R, Assi C. A systematic review on the efficacy of vitamin D supplementation on diabetic peripheral neuropathy. Clin Nutr. 2020 Oct;39(10):2970-2974. doi: 10.1016/j.clnu.2020.01.022.
Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. doi: 10.1210/jc.2007-0298.
Bajaj S, Singh RP, Dwivedi NC, Singh K, Gupta A, Mathur M. Vitamin D levels and microvascular complications in type 2 diabetes. Indian J Endocrinol Metab. 2014 Jul;18(4):537-41. doi: 10.4103/2230-8210.137512.
Senyigit A. The association between 25-hydroxy vitamin D deficiency and diabetic complications in patients with type 2 diabetes mellitus. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1381-1386. doi: 10.1016/j.dsx.2019.01.043.
Bilir B, Tulubas F, Bilir BE, Atile NS, Kara SP, Yildirim T, Gumustas SA, Topcu B, Kaymaz O, Aydin M. The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy. J Phys Ther Sci. 2016 Jul;28(7):2159-63. doi: 10.1589/jpts.28.2159.
Alam U, Nelson AJ, Cuthbertson DJ, Malik RA. An update on vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy: a narrative review. Future Neurology. 2018 Aug;13(3):135-142. Epub 2008 Jul 6. doi: 10.2217/fnl-2017-0034.
Abdelsadek SE, El Saghier EO, Abdel Raheem SI. Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus. Egypt J Neurol Psychiatr Neurosurg. 2018;54(1):36. doi: 10.1186/s41983-018-0036-9.
Ahmadieh H, Azar ST, Lakkis N, Arabi A. Hypovitaminosis d in patients with type 2 diabetes mellitus: a relation to disease control and complications. ISRN Endocrinol. 2013 Oct 22;2013:641098. doi: 10.1155/2013/641098.
Alamdari A, Mozafari R, Tafakhori A, Faghihi-Kashani S, Hafezi-Nejad N, Sheikhbahaei S, Naderi N, Ebadi M, Esteghamati A. An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects. Neurol Sci. 2015 Jul;36(7):1121-6. doi: 10.1007/s10072-015-2207-0.
Celikbilek A, Gocmen AY, Tanik N, Borekci E, Adam M, Celikbilek M, Suher M, Delibas N. Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey. Acta Neurol Belg. 2015 Mar;115(1):47-52. doi: 10.1007/s13760-014-0304-0.
Fan L, Zhang Y, Zhu J, Song Y, Lin J. Association of vitamin D deficiency with diabetic peripheral neuropathy and diabetic nephropathy in Tianjin, China. Asia Pac J Clin Nutr. 2018;27(3):599-606. doi: 10.6133/apjcn.062017.11.
He R, Hu Y, Zeng H, Zhao J, Zhao J, Chai Y, Lu F, Liu F, Jia W. Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes. Diabetes Metab Res Rev. 2017 Feb;33(2). doi: 10.1002/dmrr.2820.
Herrmann M, Sullivan DR, Veillard AS, McCorquodale T, Straub IR, Scott R, Laakso M, Topliss D, Jenkins AJ, Blankenberg S, Burton A, Keech AC; FIELD Study Investigators. Serum 25-hydroxyvitamin D: a predictor of macrovascular and microvascular complications in patients with type 2 diabetes. Diabetes Care. 2015 Mar;38(3):521-8. doi: 10.2337/dc14-0180.
Jung CH, Kim KJ, Kim BY, Kim CH, Kang SK, Mok JO. Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus. Nutr Res. 2016 Feb;36(2):117-24. doi: 10.1016/j.nutres.2015.11.008.
Lv WS, Zhao WJ, Gong SL, Fang DD, Wang B, Fu ZJ, Yan SL, Wang YG. Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis. J Endocrinol Invest. 2015 May;38(5):513-8. doi: 10.1007/s40618-014-0210-6.
Oraby, M.I., Srie, M.A., Abdelshafy, S. et al. Diabetic peripheral neuropathy: the potential role of vitamin D deficiency. Egypt J Neurol Psychiatry Neurosurg 55, 10 (2019). https://doi.org/10.1186/s41983-019-0058-y
Pinzon, Rizaldy & Angela, Angela & Pradana, Andryawan Wahyu. (2020). Is there any relationship between vitamin D levels and the severity of Diabetic peripheral neuropathy?. Romanian Journal of Neurology/ Revista Romana de Neurologie. XIX. 89-95. 10.37897/RJN.2020.2.6.
Qu GB, Wang LL, Tang X, Wu W, Sun YH. The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: An update systematic review and meta-analysis. J Clin Transl Endocrinol. 2017 Jun 3;9:25-31. doi: 10.1016/j.jcte.2017.04.001.
Saad, M., Gabr, W., Barakat, E., & Al-Gayyar, M. M. (2014). Effect of Serum Vitamin D Level on Severity of Diabetic Polyneuropathy. Egyptian Journal of Neurology, Psychiatry & Neurosurgery, 51(4).
Shillo P, Selvarajah D, Greig M, Gandhi R, Rao G, Wilkinson ID, Anand P, Tesfaye S. Reduced vitamin D levels in painful diabetic peripheral neuropathy. Diabet Med. 2019 Jan;36(1):44-51. doi: 10.1111/dme.13798.
Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N. Vitamin D deficiency and peripheral diabetic neuropathy. Eur J Intern Med. 2012 Mar;23(2):e67-8. doi: 10.1016/j.ejim.2011.11.008.
Usluogullari CA, Balkan F, Caner S, Ucler R, Kaya C, Ersoy R, Cakir B. The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus. BMC Endocr Disord. 2015 Jun 25;15:33. doi: 10.1186/s12902-015-0029-y.
Yan P, Zhang Z, Miao Y, Xu Y, Zhu J, Wan Q. Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy. Diabetol Metab Syndr. 2020 May 19;12:42. doi: 10.1186/s13098-020-00550-2.
Yang L, Zhang X, Ma X, Dong F, Tian R, Xu M. Correlation between 25-hydroxy-vitamin-d and senile diabetic peripheral neuropathy in type 2 diabetes. Biomed Res. 2017;28(14).
Zhang B, Zhao W, Tu J, Wang X, Hao Y, Wang H, Zhao Y, Mizuno K, Tseng Y, Bu H. The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy: A systematic review and a meta-analysis. Medicine (Baltimore). 2019 Nov;98(48):e18118.doi: 10.1097/MD.0000000018118.
Zhao WJ, Xia XY, Yin J. Relationship of serum vitamin D levels with diabetic microvascular complications in patients with type 2 diabetes mellitus. Chin Med J (Engl). 2021 Feb 3;134(7):814-820. doi: 10.1097/CM9.0000000000001364.
Silva Filho DR, Costa JCRS, Oliveira AM, Sandes Neto J, Sousa LP, Ribeiro BM, Nunes FG, Gomes AJCM. Associação entre a deficiência de vitamina D e a Diabetes Mellitus tipo 2: uma revisão integrativa da literatura. Association between vitamin D deficiency and type 2 Diabetes Mellitus: an integrative literature review. Brazilian Journal of Health Review, 5(6), 24613–24627.doi.org/10.34119/bjhrv5n6-216.
Azevedo MAF, Sousa MO, Barrense CO, Frota KMG, Paiva AA, Martins MCC, Carvalho CMRG. Efeito da suplementação de vitamina D sobre os parâmetros glicêmicos de idosos com diabetes tipo 2: uma revisão sistemática / Effect of vitamin D supplementation on glycemic parameters in the elderly with type 2 diabetes: a systematic review. Brazilian Journal of Health Review, 5(1), 1262–1275. doi.org/10.34119/bjhrv5n1-11
