Mecanismos de neuroinvasão por SARS-CoV-2 e suas manifestações e complicações neurológicas: uma revisão de literatura

Authors

  • Ana Beatriz Maldonado Dantas
  • Gerson Jhoseph Lima dos Santos
  • Gabriel Gomes Ranite
  • William Rodrigues da Silva
  • Sergio Daniel Fanola Justiniano

DOI:

https://doi.org/10.34119/bjhrv6n6-099

Keywords:

manifestações neurológicas, complicações neurológicas, fisiopatologia, infecção COVID-19

Abstract

Desde a pandemia da COVID-19, manifestações e complicações neurológicas foram cada vez mais descritas como importantes impactos da infecção pelo SARS-CoV-2. Decorrente deste fato, diversos estudos foram feitos visando corroborar com a elucidação dos mecanismos fisiopatológicos deste quadro neurológico. Várias manifestações neurológicas foram associadas à COVID-19, desde as mais brandas, como disfunções olfatórias e gustativas, até as mais graves, como o acidente vascular cerebral. Em vista disso, observa-se que essa problemática pode apresentar repercussões a curto, médio e longo prazo, sendo de grande relevância para estudos. Logo, esse estudo teve como objetivo apresentar as repercussões da pandemia da COVID-19 sob a óptica da fisiopatologia e, principalmente, nas manifestações e complicações neurológicas, demonstrando a importância da temática nesse cenário.  O método utilizado foi a revisão literária, através das bases de dados PubMed, buscando compilar e demonstrar as informações mais relevantes até o momento. Espera-se incentivar e subsidiar estudos padronizados posteriores sobre o COVID-19 para melhor abordagem terapêutica por meio da compreensão da sua fisiopatologia.

References

ADORNI, Fulvio et al. Self-Reported Symptoms of SARS-CoV-2 Infection in a Nonhospitalized Population in Italy: Cross-Sectional Study of the EPICOVID19 Web-Based Survey. JMIR public health and surveillance, v. 6, n. 3, p. e21866–e21866, 18 set. 2020. DOI: 10.2196/21866

AGGARWAL, A.; SINGHAL, T.; BHATT, M. Neurology and COVID-19: Acting now. Preparing for future. Annals of Indian Academy of Neurology, v. 23, n. 4, p. 433–433, 1 jan. 2020. DOI: 10.4103/aian.AIAN_513_20

ASHRAFI, F. et al. COVID-19-related strokes in adults below 55 years of age: a case series. Neurological Sciences, v. 41, n. 8, p. 1985–1989, 24 jun. 2020. DOI: 10.1007/s10072-020-04521-3

BARROS, Gustavo et al. Analysis of neurological disorders in people who had COVID-19 in Brazil. Brazilian Journal of Development, v.9, n.5, p.17749-17758, 22 may. 2023. DOI: 10.34117/bjdv9n5-217

BHAVIKA, Kakadia et al. Mild encephalopathy with reversible splenium lesion (MERS) in a patient with COVID-19. Journal of Clinical Neuroscience, v. 79, p. 272–274, 1 set. 2020. DOI: 10.1016/j.jocn.2020.07.009

CABIRAC, G. F. et al. Entry of coronavirus into primate CNS following peripheral infection. Microbial Pathogenesis, v. 16, n. 5, p. 349–357, 1 maio 1994. DOI: 10.1006/mpat.1994.1035

CARIDDI, Lucia P. et al. Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient. Journal of Neurology, v. 267, n. 11, p. 3157–3160, 24 jun. 2020. DOI: 10.1007/s00415-020-10001-7

CAROD-ARTAL, Francisco J. Complicaciones neurológicas por coronavirus y COVID-19. Revista De Neurologia, v. 70, n. 09, p. 311–311, 1 jan. 2020. DOI: 10.33588/rn.7009.2020179

COOMES, E. A.; HOURMAZD HAGHBAYAN. Interleukin‐6 in Covid‐19: A systematic review and meta‐analysis. Reviews in Medical Virology, v. 30, n. 6, p. 1–9, 26 ago. 2020. DOI: 10.1002/rmv.2141

FRANKE, Christiana; BERLIT, Peter; PRÜSS, Harald. Neurological manifestations of post-COVID-19 syndrome S1-guideline of the German society of neurology. Neurological Research And Practice, [S.L.], v. 4, n. 1, 18 jul. 2022. Springer Science and Business Media LLC. http://dx.doi.org/10.1186/s42466-022-00191-y.

HENSLEY, M.; MARKANTONE, D. M.; PRESCOTT, H. C. Neurologic Manifestations and Complications of COVID-19. Annual Review of Medicine, v. 73, n. 1, p. 113–127, 27 jan. 2022. DOI: 10.1146/annurev-med-042320-010427

IZQUIERDO-DOMÍNGUEZ, A. et al. Olfactory Dysfunction in the COVID-19 Outbreak. Journal of Investigational Allergology and Clinical Immunology, v. 30, n. 5, p. 317–326, 2 out. 2020. DOI: 10.18176/jiaci.0567

JASTI, M. et al. A review of pathophysiology and neuropsychiatric manifestations of COVID-19. Journal of Neurology, v. 268, n. 6, p. 2007–2012, 3 jun. 2020. DOI: 10.1007/s00415-020-09950-w

KANWAR, D.; BAIG, Abdul M.; WASAY, M. Neurological manifestations of COVID-19. Journal of Pakistan Medical Association, n. 0, p. 1–1, 1 jan. 2020. DOI: 10.5455/JPMA.20

KARAPANAYIOTIDES, Theodoros et al. Concentric demyelination pattern in COVID-19-associated acute hemorrhagic leukoencephalitis: a lurking catastrophe? Brain, v. 143, n. 12, p. e100–e100, 16 out. 2020. DOI: 10.1093/brain/awaa375

KHATOON, F.; PRASAD, K.; KUMAR, V. COVID-19 associated nervous system manifestations. Sleep Medicine, v. 91, p. 231–236, 1 mar. 2022. DOI: https://doi.org/10.1016/j.sleep.2021.07.005

LEE, Jong M.; LEE, Sang J. Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report. Journal of Korean Medical Science, v. 35, n. 21, 1 jan. 2020. DOI: 10.3346/jkms.2020.35.e201

LUO, W. et al. Ischemic stroke associated with COVID-19: a systematic review and meta-analysis. Journal of Neurology, v. 269, n. 4, p. 1731–1740, 15 out. 2021. DOI: 10.1007/s00415-021-10837-7

MEYER, Philipp T. et al. Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: a systematic review. Journal Of Nuclear Medicine, [S.L.], v. 63, n. 7, p. 971-980, 17 fev. 2022. Society of Nuclear Medicine. http://dx.doi.org/10.2967/jnumed.121.263085.

NIKITINA, A. Yu.; CHIMAGOMEDOVA, A. Sh.; LEVIN, O. S. Neurological Complications of COVID-19 in the Elderly. Neuroscience And Behavioral Physiology, [S.L.], v. 52, n. 5, p. 625-634, jun. 2022. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/s11055-022-01287-3.

ORENDÁČOVÁ, Mária; KVAŠŇÁK, Eugen. Possible Mechanisms Underlying Neurological Post-COVID Symptoms and Neurofeedback as a Potential Therapy. Frontiers in Human Neuroscience, v. 16, 31 mar. 2022. DOI: 10.3389/fnhum.2022.837972

ORRÙ, Graziella et al. Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review. International Journal of Environmental Research and Public Health, v. 17, n. 18, p. 6688–6688, 14 set. 2020. DOI: 10.3390/ijerph17186688

RENSON, T.; HAMIWKA, L.; BENSELER, S. M. Central nervous system manifestations of monogenic autoinflammatory disorders and the neurotropic features of SARS-CoV-2: Drawing the parallels. Frontiers in Pediatrics, v. 10, 10 ago. 2022. DOI: 10.3389/fped.2022.931179

SCOPPETTUOLO, Pasquale; BORRELLI, Serena; NAEIJE, Gilles. Neurological involvement in SARS-CoV-2 infection: a clinical systematic review. Brain, Behavior, & Immunity - Health, [S.L.], v. 5, p. 100094, maio 2020. Elsevier BV. http://dx.doi.org/10.1016/j.bbih.2020.100094.

SHAHID, Mubasshar et al. Unilateral Diaphragmatic Paralysis in a Patient With COVID-19 Pneumonia. Cureus, [S.L.], 6 nov. 2021. Cureus, Inc.. http://dx.doi.org/10.7759/cureus.19322. DOI: 10.1146/annurev-med-042320-010427

SOUZA, Valdir P. J.; SOUZA, Luciana S.; ZANELLA, Juliane C. Síndrome pós COVID: alterações cognitivas em pacientes psiquiátricos, uma série de casos. Brazilian Journal of Development, v.8, n.10, p.68440-68460, 19 oct. 2022. DOI: 10.34117/bjdv8n10-224

SUÁREZ-SÁNCHEZ, Donají et al. Post-Coronavirus Disease 2019 Triggers the Appearance of Mixed Polyneuropathy and Brain Fog: a case report. Clinics And Practice, [S.L.], v. 12, n. 3, p. 261-267, 25 abr. 2022. MDPI AG. http://dx.doi.org/10.3390/clinpract12030031.

TAN, Lynn et al. Neurological implications of COVID-19: a review of the science and clinical guidance. Bmj Neurology Open, [S.L.], v. 2, n. 2, dez. 2020. BMJ. http://dx.doi.org/10.1136/bmjno-2020-000101.

TULIUS, M.; LIMA, Marco A.; ARAUJO, A. SARS-CoV-2: Should We Be Concerned about the Nervous System? American Journal of Tropical Medicine and Hygiene, v. 103, n. 3, p. 993–998, 2 set. 2020. DOI: 10.4269/ajtmh.20-0447

VONCK, Kristl et al. Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2. European Journal of Neurology, v. 27, n. 8, p. 1578–1587, 16 jun. 2020. DOI: 10.1111/ene.14329

WIJERATNE, Tissa; CREWTHER, S. G. Post-COVID 19 Neurological Syndrome (PCNS); a novel syndrome with challenges for the global neurology community. Journal of the Neurological Sciences, v. 419, p. 117179–117179, 1 dez. 2020. DOI: 10.1016/j.jns.2020.117179

YADAV, Ramakant et al. Systemic review of CNS involvement and its manifestations in SARS-CoV2 positive patients. Journal Of Infection And Public Health, [S.L.], v. 14, n. 6, p. 734-739, jun. 2021. Elsevier BV. http://dx.doi.org/10.1016/j.jiph.2021.03.005.

ZHAO, Fangfang et al. Neurological Manifestations of COVID-19: causality or coincidence?. Aging And Disease, [S.L.], v. 12, n. 1, p. 27, 2021. Aging and Disease. http://dx.doi.org/10.14336/ad.2020.0917

Published

2023-11-13

How to Cite

Dantas, A. B. M., dos Santos, G. J. L., Ranite, G. G., da Silva, W. R., & Justiniano, S. D. F. (2023). Mecanismos de neuroinvasão por SARS-CoV-2 e suas manifestações e complicações neurológicas: uma revisão de literatura. Brazilian Journal of Health Review, 6(6), 27790–27810. https://doi.org/10.34119/bjhrv6n6-099

Issue

Section

Original Papers