Chronic Lymphoid Leukemia: a systematic review of its epidemiological, etiological and genetic aspects

Authors

  • Bruno Issao Kobayashi
  • Luiza Bortoloti Dias
  • Vinicius Camargo Achermann

DOI:

https://doi.org/10.34119/bjhrv6n5-325

Keywords:

chronic lymphoid leukemia, epidemiology, etiology

Abstract

Chronic lymphocytic leukemia (CLL) is a lymphoproliferative neoplasm that mainly affects the elderly, being the most common leukemia in western adults. It is estimated the presence of about 191,000 new cases annually in the world. Despite the advances made in the diagnosis and therapeutic management of CLL, its etiological and genetic aspects are still not completely clear. The objective of the article was to address and bring together the main epidemiological and etiopathogenic aspects of CLL, exploring how a greater biological understanding of the disease can improve and generate new therapeutic strategies.

References

Rossi D, Sozzi E, Puma A, et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol 2009; 146:64.

Shanafelt TD, Kay NE, Rabe KG, et al. Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol 2009; 27:3959.

Damle RN, Ghiotto F, Valetto A, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 2002; 99:4087.

Burger JA, Landau DA, Taylor-Weiner A, Bozic I, Zhang H, Sarosiek K, Wang L, Stewart C, Fan J, Hoellenriegel J, et al. Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Nat Commun. 2016; 7:11589.

Woyach JA, Johnson AJ, Byrd JC. The B cell receptor signaling pathway as a therapeutic target in CLL. Blood.2012;120:1175-84.

INCA. Estimativa 2020/2022 –Estimativa de Leucemia Linfocitica Crônica. Disponível em: < https://www.inca.gov.br/estimativa >.

Stamatopoulos K. Antigens in CLL: themes and variations. Blood 2010; 115:3855-6.

Suping Z, Kipps JT. The Pathogenesis of Chronic Lymphocytic Leukemia. Ann Rev Pathol. 2014;9:103-18. doi:10.1146/annurev-pathol-020712-163955.

Rozovski U, Hazan-Halevy I, Keating MJ, Estrov Z. Personalized medicine in CLL: Current status and futureperspectives. Cancer Lett. 2014;352:4-14.

Mertens D, Stilgenbauer S. Prognostic and predictive factors in patients with chronic lymphocytic leukemia: Relevant in the era of novel treatment approaches? J Clin Oncol 2014;32:869-72.

Seifert M, Sellmann L, Bloehdorn J, Wein F, Stilgenbauer S, Durig J, Kuppers R. Cellular origin and pathophysiology of chronic lymphocytic leukemia. J Exp Med. 2012; 209:2183–2198.

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Published

2023-09-25

How to Cite

KOBAYASHI, B. I.; DIAS, L. B.; ACHERMANN, V. C. Chronic Lymphoid Leukemia: a systematic review of its epidemiological, etiological and genetic aspects. Brazilian Journal of Health Review, [S. l.], v. 6, n. 5, p. 23045–23050, 2023. DOI: 10.34119/bjhrv6n5-325. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/63427. Acesso em: 18 may. 2024.

Issue

Section

Original Papers