Infecção por SARS-CoV-2 e o impacto no sistema nervoso central
DOI:
https://doi.org/10.34119/bjhrv6n4-085Keywords:
COVID-19, SARS-CoV-2, alterações neurológicas, alterações do sistema nervoso centralAbstract
Objetivo: Analisar os efeitos da infecção pelo SARS-CoV-2 sobre o SNC. Métodos: Foi realizado um estudo observacional retrospectivo a partir da base de dados DATASUS. Foi selecionado um total de 18.027 pacientes internados. Os critérios de seleção foram baseados no "dicionário de dados" do Ministério da Saúde, sendo a idade (mais de 18 anos), e a classificação final dos casos " SARS pela COVID-19". O odds ratio foi utilizado para medir a associação entre as manifestações neurológicas e o mau resultado da doença. Resultados: As manifestações neurológicas foram relatadas em 51,9% dos doentes. Fadiga, dor de cabeça e vómitos foram as manifestações mais comuns relacionadas com o SNC, mostrando uma associação negativa significativa com a mortalidade (respectivamente OR: 0.92, 95% CI: 0.86-0.98, p = 0.01861; OR: 0.55, 95% CI: 0.50-0.60, p < 0,0000001; OR: 0.84, 95% CI: 0.75-0.93, p = 0.001670). A alteração no paladar e/ou olfato apresentou associação negativa com necessidade de internação na UTI (OR: 0.77, p < 0.0000001) e mortalidade (OR: 0.67, p < 0.0000001). O AVC foi incomum, mas apresentou taxas elevadas de admissão e mortalidade na UTI (ambos 41,7%). Convulsão apresentou associação a internação na UTI. Conclusão: As manifestações neurológicas são comuns na infecção pela SARS-CoV-2. Sugere-se que perturbações neurológicas mais comuns e inespecíficas estão negativamente associadas a maus resultados da doença assim como as alterações de olfato e/ou paladar.
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