Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder
DOI:
https://doi.org/10.34119/bjhrv6n3-235Keywords:
gestation, HPA axis, fetal programmingAbstract
Pregnancy is a critical development period, in a way that small alterations can be crucial in shaping an individual's health for the rest of his life. Depending on wich adversive conditions the fetus is exposed to, like metabolic, hormonal and nutricional alterations by the mother, there is a higher susceptibility in developing certain diseases, syndromes and disturbs. Among the aforementioned adversities, we can mention the excessive use of synthetic glucocorticoids during pregnancy. It is known that glucocorticoids act at various levels within the fetal brain, physiologically modulating the individual's neurological function, and, by that, exposing him to cognitive decline and behavioral changes. This review aimed to explore some evidence of the impact of excessive glucocorticoid signaling on HPA axis modulation and consequent fetal adaptive changes, related to the vulnerability of the development of Attention Deficit Hyperactivity Disorder (ADHD). In view of the growing number of diagnoses of this disease, it is necessary to review medical recommendations, the use of these drugs by pregnant women and infants, and public health policies.
References
ALTARESCU A, CRAIG MC, GLOVER V. Prenatal stress: Effects on fetal and child brain development. International Review of Neurobiology. 2020 ;150:17-40. DOI: 10.1016/bs.irn.2019.11.002. PMID: 32204831.
BARBOSA, Ariadne. Programação metabólica por exposição materna ao glifosato: avaliação morfológica dos músculos extensor longo dos dedos e sóleo de camundongos C57BL/6. 2020. 95 f. Dissertação (Programa de Pós- Graduação em Biociências e Saúde) - Universidade Estadual do Oeste do Paraná, Cascavel - PR.
BATTARBEE AN, YE Y, SZYCHOWSKI JM, CASEY BM, TITA AT, BOGGESS KA. Euglycemia after antenatal late preterm steroids: a multicenter, randomized controlled trial. Am J Obstet Gynecol MFM. 2022 Jul;4(4):100625. doi: 10.1016/ j.ajogmf.2022.100625. Epub 2022 Mar 26. PMID: 35346889; PMCID: PMC9195161.
BAVARESCO, Luci; BERNARDI, Andressa; BATTASTINI, Ana Maria Oliveira. GLICOCORTICOIDES: USOS CLÁSSICOS E EMPREGO NO TRATAMENTO DO CÂNCER. Infarma - Ciências Farmacêuticas, [S.l.], v. 17, n. 7/9, p. 50-60, jan. 2013. ISSN 2318-9312. Disponível em: <http://www.revistas.cff.org.br/? journal=infarma&page=article&op=view&path%5B%5D=260>. Acesso em: 25 jan. 2022.
BEHURA SK, DHAKAL P, KELLEHER AM, BALBOULA A, PATTERSON A, SPENCER TE. The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy. Pharmacol Res. 2019 Nov;149:104468. doi: 10.1016/ j.phrs.2019.104468. Epub 2019 Oct 7.
BENZING, Valentin; SCHMIDT, Mirko. The effect of exergaming on executive functions in children with ADHD: a randomized clinical trial. Scandinavian Journal Of Medicine & Science In Sports, [S.L.], v. 29, n. 8, p. 1243-1253, 23 maio 2019. Wiley. http://dx.doi.org/10.1111/sms.13446.
BRUNTON, L. L. As bases farmacológicas da terapêutica de Goodman e Gilman. Porto Alegre: AMGH, 2018.
BUSADA, J. T., & CIDLOWSKI, J. A. (2017). Mechanisms of Glucocorticoid Action During Development. Nuclear Receptors in Development and Disease, 147–170. doi:10.1016/bs.ctdb.2016.12.
CAI, Emmy; CZUZOJ-SHULMAN, Nicolas e ABENHAIM, Haim A. Maternal and fetal outcomes in pregnancies with long-term corticosteroid use, The Journal of Maternal-Fetal & Neonatal Medicine, 34:11, 1797-1804; 2021. DOI: 10.1080/14767058.2019.1649392
CASTRO, María J. Programación fetal. Revista Digital de Postgrado, Caracas, v. 9, n. 2, p. 1-14, ago. 2020. Disponível em: https://pesquisa.bvsalud.org/portal/ resource/pt/biblio-1103446. Acesso em: 10 dez. 2021.
CASULARI, Luiz Augusto; MOTTA, Lucilia Casulari da. Antenatal corticosteroids may contribute to illness in children in the future. Arch. Endocrinol. Metab., São Paulo , v. 66, n. 1, p. 129-131, Feb. 2022 . Available from <http://old.scielo.br/ scielo.php?script=sci_arttext&pid=S2359-39972022000100129&lng=en&nrm=iso>. access on 30 Apr. 2022. Epub Mar 16, 2022. https://doi.org/ 10.20945/2359-3997000000434.
CHEN, X., Wang, M., Zhang, Q., Hou, Y., Huang, X., Li, S., & Wu, J. (2019). Stress response genes associated with attention deficit hyperactivity disorder: a case-control study in Chinese children. Behavioural Brain Research. doi:10.1016/ j.bbr.2019.01.
CHEN, Yanhui; ZHENG, Xiaolan; XIE, Linqi; HUANG, Liang; KE, Zhongling; ZHENG, Jie; LU, Hongzhu; HU, Jun. Glucocorticoids/glucocorticoid receptors effect on dopaminergic neurotransmitters in ADHD rats. Brain Research Bulletin, [S.L.], v. 131, p. 214-220, maio 2017. Elsevier BV. http://dx.doi.org/10.1016/j.brainresbull. 2017.04.013.
COSTA, Débora Bomfim; COELHO, Helena Lutescia Luna; SANTOS, Djanilson Barbosa dos. Utilização de medicamentos antes e durante a gestação: prevalência e fatores associados. Cad. Saúde Pública, Rio de Janeiro , v. 33, n. 2, e00126215, 2017 . Disponível em <http://www.scielo.br/scielo.php? script=sci_arttext&pid=S0102-311X2017000205005&lng=pt&nrm=iso>. acessos em 15 mar. 2021. Epub 09-Mar-2017. https://doi.org/10.1590/0102-311x00126215.
CUTOLO M, LACCARINO L, DORIA A, GOVONI M, SULLI A, MARCASSA C. Efficacy of the switch to modified-release prednisone in rheumatoid arthritis patients treated with standard glucocorticoids. Clin Exp Rheumatol. 2013 Jul- Aug;31(4):498-505. Epub 2013 Feb 15. PMID: 23415134.
FALL, Caroline H. D.; KUMARAN, Kalyanaraman. Metabolic programming in early life in humans. Philos Trans R Soc Lond B Biol Sci, London, v. 1, p. 374-383, 15 abr. 2019. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460078/. Acesso em: 15 ago. 2021.
FORTIER, Marie-Ève; SENGUPTA, Sarojini M.; GRIZENKO, Natalie; CHOUDHRY, Zia; THAKUR, Geeta; JOOBER, Ridha. Genetic Evidence for the Association of the Hypothalamic–Pituitary–Adrenal (HPA) Axis with ADHD and Methylphenidate Treatment Response. Neuromolecular Medicine, [S.L.], v. 15, n. 1, p. 122-132, 10 out. 2012. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/ s12017-012-8202-1.
FOWDEN, A.L.; VALENZUELA, O.A.; VAUGHAN, O.R.; JELLYMAN, J.K.; FORHEAD, A.J.. Glucocorticoid programming of intrauterine development. Domestic Animal Endocrinology, [S.L.], v. 56, n. 8, p. 121-132, jul. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.domaniend.2016.02.014.
GJERSTAD, Julia K; LIGHTMAN, Stafford L; SPIGA, Francesca. Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility. Taylor and Francis, Bristol, v. 5, n. 1, p. 403-416, 15 maio 2018. Disponível em: https:// www.tandfonline.com/doi/full/10.1080/10253890.2018.1470238. Acesso em: 11 mar. 2022.
GLOVER, V., O'DONNELL, K., O'CONNOR, T., & FISHER, J. (2018). Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective. Development and Psychopathology, 30(3), 843-854. doi:10.1017/S095457941800038X
GRAY, J., KOGAN, J., MARROCCO, J. et ai. Mecanismos genômicos e epigenômicos dos glicocorticoides no cérebro. Nat Rev Endocrinol 13, 661-673 (2017). https://doi.org/10.1038/nrendo.2017.97
HANC Tomasz, CORTESE Samuele, Attention deficit/hyperactivity-disorder and obesity: A review and model of current hypotheses explaining their comorbidity, Neuroscience & Biobehavioral Reviews, Volume 92, 2018, Pages 16-28, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2018.05.017.
HERMAN, James P.; MCKLVEEN, Jessica M.; GHOSAL, Sriparna; KOPP, Brittany; WULSIN, Aynara; MAKINSON, Ryan; SCHEIMANN, Jessie; MYERS, Brent. Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. Comprehensive Physiology, [S.L.], p. 603-621, 15 mar. 2016. Wiley. http:// dx.doi.org/10.1002/cphy.c150015.
KATZUNG, B. Farmacologia básica e clínica. Porto Alegre: AMGH, 2017. ISBN 9788580555967. Disponível em: https://search.ebscohost.com/login.aspx? direct=true&db=edsmib&AN=edsmib.000011541&lang=pt-br&site=eds-live. Acesso em: 10 jan. 2021.
LAUGESEN, Kristina; BYRJALSEN, Anna; FRØSLEV, Trine; OLSEN, Morten s; SØRENSEN, Henrik Toft. Use of glucocorticoids during pregnancy and risk of attention-deficit/hyperactivity disorder in offspring: a nationwide danish cohort study. Bmj Open, [S.L.], v. 7, n. 9, p. 016825, set. 2017. BMJ. http://dx.doi.org/ 10.1136/bmjopen-2017-016825.
LESTER, BARRY M and CARMEN, J Marsit. “Epigenetic mechanisms in the placenta related to infant neurodevelopment.” Epigenomics vol. 10,3 (2018): 321-333. doi:10.2217/epi-2016-0171
LIMA TELES DA HORA, A.; SILVA, S.; RAMOS, M.; PONTES, F.; NOBRE, J. A prevalência do transtorno do déficit de atenção e hiperatividade (tdah): Uma revisão de literatura. PSICOLOGIA, v. 29, n. 2, p. 47-62, 1 dez. 2015.
LONGUI, Carlos Alberto. Corticoterapia: minimizando efeitos colaterais. Sociedade Brasileira de Pediatria: Jornal de Pediatria. Rio de Janeiro, p. 163-171. nov. 2007. Disponível em: https://www.scielo.br/j/jped/a/fjqmm8pXQSkrqPGRnk6TTgD/? lang=pt#. Acesso em: 18 jan. 2022.
M.D. Lockshin; L.R. Sammaritano. Corticosteroids during pregnancy, Scandinavian Journal of Rheumatology, 27:sup107, 136-138; 2016. DOI: 10.1080/03009742.1998.11720789
MARCINIAK, Aleksandra; PATRO-MAłYSZA, Jolanta; KIMBER-TROJNAR, Żaneta; MARCINIAK, Beata; OLESZCZUK, Jan; LESZCZYńSKA-GORZELAK, Bożena. Programação fetal da síndrome metabólica. Lublin: Elsevier, 2017. 133-138 p. Disponível em: https://www.sciencedirect.com/science/article/pii/ S1028455917300025?via%3Dihub. Acesso em: 15 dez. 2021.
MCEWEN, Bruce s; NASCA, Carla; GRAY, Jason D. Stress Effects on Neuronal Structure: hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology, [S.L.], v. 41, n. 1, p. 3-23, 16 jun. 2015. Springer Science and Business Media LLC. http://dx.doi.org/10.1038/npp.2015.171.
MEER, D. van Der; HOEKSTRA, P. J.; BRALTEN, J.; VAN DONKELAAR, M.; HESLENFELD, D. J.; OOSTERLAAN, J.; FARAONE, S. V.; FRANKE, B.;
BUITELAAR, J. K.; HARTMAN, C. A.. Interplay between stress response genes associated with attention-deficit hyperactivity disorder and brain volume. Genes, Brain And Behavior, [S.L.], v. 15, n. 7, p. 627-636, 3 ago. 2016. Wiley. http:// dx.doi.org/10.1111/gbb.12307.
MONTENEGRO YHA, de QUEIROGA NASCIMENTO D, de ASSIS TO, Santos- Lopes SSD. The epigenetics of the hypothalamic-pituitary-adrenal axis in fetal development. Ann Hum Genet. 2019 Jul;83(4):195-213. doi: 10.1111/ahg.12306. Epub 2019 Mar 7. PMID: 30843189.
MORGADO, Pedro et al. Resposta Neuronal ao Stress. In: MINHO, Universidade do. Instituto de Investigação em Ciências da Vida e Saúde (ICVS). Braga: Lidel - Edições Técnicas, 2017. p. 1-18. Disponível em: http://repositorium.sdum.uminho.pt/ handle/1822/50828. Acesso em: 17 abr. 2022.
NAKAI T, KITADA A, FUKUI S, OKADA M. Risk of adverse pregnancy outcomes in Japanese systemic lupus erythematosus patients with prior severe organ manifestations: A single-center retrospective analysis. Lupus. 2021 Aug;30(9): 1415-1426. doi: 10.1177/09612033211016074. Epub 2021 May 20. PMID: 34013819.
NOORDERMEER, Siri D. S.; LUMAN, Marjolein; OOSTERLAAN, Jaap. A Systematic Review and Meta-analysis of Neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) Taking Attention-Deficit Hyperactivity Disorder (ADHD) Into Account. Neuropsychology Review, [S.L.], v. 26, n. 1, p. 44-72, 5 fev. 2016. Springer Science and Business Media LLC. http:// dx.doi.org/10.1007/s11065-015-9315-8.
NORONHA, Gisele Almeida de; KALE, Pauline Lorena; TORRES, Tania Zdenka Guillén de; COSTA, Antonio Jose Leal; CAVALCANTI, Maria de Lourdes Tavares; SZKLO, Moyses. Validade da informação sobre o peso ao nascer para estudos fundamentados na programação fetal. Caderno de Saúde Pública, Rio de Janeiro, v. 1, n. 7, p. 1-12, 10 jul. 2017. Disponível em: https://www.scielo.br/j/csp/a/ hvWrXHm3by7YZyx3mdT4XYB/?lang=pt. Acesso em: 17 ago. 2021.
O’DONNELL, Kieran J.; MEANEY, Michael J.. Fetal Origins of Mental Health: the developmental origins of health and disease hypothesis. American Journal Of Psychiatry, [S.L.], v. 174, n. 4, p. 319-328, abr. 2017. American Psychiatric Association Publishing. http://dx.doi.org/10.1176/appi.ajp.2016.16020138.
OWEN, D., Andrews, M. H., & Matthews, S. G. (2005). RETRATADO: Adversidade materna, glicocorticoides e programação da função e comportamento neuroendócrino. Neuroscience & Biobehavioral Reviews, 29 (2), 209–226. doi: 10.1016 / j.neubiorev.2004.10.
OYOLA MG, Handa RJ. Hypothalamic-pituitary-adrenal and hypothalamic- pituitary-gonadal axes: sex differences in regulation of stress responsivity. Stress. 2017 Sep;20(5):476-494. doi: 10.1080/10253890.2017.1369523. Epub 2017 Aug 31. PMID: 28859530; PMCID: PMC5815295.
PATRICK O McGowan, STEPHEN G Matthews, Prenatal Stress, Glucocorticoids, and Developmental Programming of the Stress Response, Endocrinology, Volume 159, Issue 1, January 2018, Pages 69–82, https://doi.org/10.1210/en. 2017-00896
PAULINO, Jéssica et al. Uso indiscriminado de glicocorticoides e sua consequencia fetal durante a gestação. 2021. 8 f. TCC (Graduação) - Curso de Farmácia, Univag, Várzea Grande, 2021. Disponível em: https:// www.repositoriodigital.univag.com.br/index.php/far/article/view/663. Acesso em: 17 jan. 2022.
PEARSON, Jessica; TARABULSY, George M.; BUSSIÈRES, Eve-Line. Foetal programming and cortisol secretion in early childhood: a meta-analysis of different programming variables. Infant Behavior And Development, [S.L.], v. 40, p. 204-215, ago. 2015. Elsevier BV. http://dx.doi.org/10.1016/j.infbeh.2015.04.004.
PERRONE S, SANTACROCE A, PICARDI A, BUONOCORE G. Fetal programming and early identification of newborns at high risk of free radical-mediated diseases. World J Clin Pediatr 2016; 5(2): 172-181 [PMID: 27170927 DOI: 10.5409/ wjcp.v5.i2.172]
REYNOLDS, Rebecca M.. Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis ⠳ 2012 curt richter award winner. Psychoneuroendocrinology, [S.L.], v. 38, n. 1, p. 1-11, jan. 2013. Elsevier BV. http://dx.doi.org/10.1016/j.psyneuen.2012.08.012.
RIBEIRO, Alinne Souza et al. RISCO POTENCIAL DO USO DE MEDICAMENTOS DURANTE A GRAVIDEZ E A LACTAÇÃO.Infarma - Ciências Farmacêuticas, [S.l.], v. 25, n. 1, p. 62-67, apr. 2013. ISSN 2318-9312. Disponível em: . Acesso em: 25 jan. 2022. doi:http://dx.doi.org/ 10.14450/2318-9312.v25.e1.a2013.pp62-67.
POLDERMAN JA, FARHANG-RAZI V, VAN DIEREN S, KRANKE P, DEVRIES JH, HOLLMANN MW, PRECKEL B, HERMANIDES J. Adverse side effects of dexamethasone in surgical patients. Cochrane Database Syst Rev. 2018 Nov 23;11(11):CD011940. doi: 10.1002/14651858.CD011940.pub3. PMID: 30480776; PMCID: PMC6426282.
ROLDÃO, Carolina Fidalgo da Cruz. Leite materno e programação metabólica: benefícios para a saúde a curto e a longo prazo. 2019. 35 f. Dissertação (Mestrado) - Curso de Medicina, Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, 2019. Disponível em: https://repositorio-aberto.up.pt/bitstream/ 10216/121296/2/343878.pdf. Acesso em: 22 dez. 2021.
SACCONE, Gabriele; BERGHELLA, Vincenzo. Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials. Bmj, [S.L.], p. 5044, 12 out. 2016. BMJ. http:// dx.doi.org/10.1136/bmj.i5044.
SADLER, T. W. Langman Embriologia médica. Rio de Janeiro: Guanabara Koogan, 2021. ISBN 9788527736022. Disponível em: https://search.ebscohost.com/ login.aspx?direct=true&db=edsmib&AN=edsmib.000020926&lang=pt-br&site=eds- live. Acesso em: 9 mar. 2022.
SAÚDE, Ministério da. Gestação de Alto Risco. 5. ed. Brasília: Editora Ms, 2012. 302 p. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/ manual_tecnico_gestacao_alto_risco.pdf. Acesso em: 20 jan. 2022.
SCHOTE, Andrea B.; BONENBERGER, Martina; PÁLMASON, Haukur; SEITZ, Christiane; MEYER, Jobst; FREITAG, Christine M.. Glucocorticoid receptor variants in childhood attention-deficit/hyperactivity disorder and comorbid psychiatric disorders. Psychiatry Research, [S.L.], v. 246, p. 275-283, dez. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.psychres.2016.10.001.
SIQUEIRA, Marcelo Martins; FARIA, Talitha Araújo. Efeitos Colaterais no Organismo Humano no uso de Glicocorticoides. Sete Lagoas: Uniatenas, 2017. Disponível em: http://www.atenas.edu.br/uniatenas/assets/files/magazines/ EFEITOS_COLATERAIS_NO_ORGANISMO_HUMANO_NO_USO_DE_GLICOCOR TICOIDES.pdf. Acesso em: 20 jan. 2022
TAVARES, F. R. S. .; LUZ , E. R. da .; SILVA, C. E. G. da .; CARVALHO , J. M. . L. de B. .; SOUSA, A. P. de .; FERREIRA, M. D. L. . Deleterious effects of chronic use of corticosteroids: an approach to the development of Cushing’s Syndrome. Research, Society and Development, [S. l.], v. 10, n. 4, p. e12310413487, 2021. DOI: 10.33448/rsd-v10i4.13487. Disponível em: https://rsdjournal.org/index.php/rsd/ article/view/13487. Acesso em: 10 fev. 2022.
WU, L.H., CHENG, W., YU, M. et al. Nr3C1-Bhlhb2 Axis Dysregulation Is Involved in the Development of Attention Deficit Hyperactivity. Mol Neurobiol 54, 1196–1212 (2017). https://doi.org/10.1007/s12035-015-9679-z
XIONG, Fuxia; ZHANG, Lubo. Role of the hypothalamic–pituitary–adrenal axis in developmental programming of health and disease. Frontiers In
Neuroendocrinology, [S.L.], v. 34, n. 1, p. 27-46, jan. 2013. Elsevier BV. http:// dx.doi.org/10.1016/j.yfrne.2012.11.002.
ZHU Y, WANG Y, YANG Z, WANG L, HU X. Endogenous cortisol-related alterations of right anterior insula functional connectivity under acute stress. J Affect Disord. 2020 Sep 1;274:231-238. doi: 10.1016/j.jad.2020.05.123. Epub 2020 May 23. PMID: 32469811.
