A busca de melhoria no tratamento da dor crônica: o que se sabe sobre a proloterapia
DOI:
https://doi.org/10.34119/bjhrv6n3-082Keywords:
dor crônica, proloterapia, dextroseAbstract
Dor crônica é definida como uma dor recorrente ou persistente que afeta o indivíduo por mais de três meses e está associada a um significativo sofrimento ou perda da qualidade de vida. O tratamento da dor crônica, normalmente se faz com o uso de medicamentos, como os opióides, os quais apresentam diversos efeitos colaterais e quadros de dependência. Sendo assim, se faz necessário a busca por outras alternativas de tratamento como a proloterapia. A proloterapia é o procedimento em que há injeção de dextrose de concentração variada - de 5 até 25% - guiada ou não por ultrassom para um tecido lesado. Seu mecanismo de ação não é completamente elucidado, no entanto, acredita-se que adição de dextrose realiza uma inflamação inicialmente, com posterior remodelação tecidual e melhora da dor. O trabalho teve por finalidade agrupar o conhecimento que se há sobre o uso de proloterapia como tratamento para dor crônica.: Foi realizada uma busca nas bases de dados: PUBMED; SCIELO; Google Acadêmico e LILACS, com as palavras-chave: “Dor crônica” e “Proloterapia” ou “Dextrose”, sendo filtrados somente artigos publicados nos últimos 10 anos, realizados em humanos e com texto completo. Foram encontrados 83 artigos, e após análise do resumo restaram 24. Foi realizada a leitura na integra destes 24 artigos e agrupadas as principais informações, além de seus respectivos resultados. Em suma, 19 dentre os 24 artigos demonstraram eficácia no tratamento com proloterapia, 3 artigos mostraram resultados favorecendo outras opções de tratamento, porém observou-se uma lacuna de conhecimento sobre o mecanismo de ação da terapia e seu tempo de eficácia.
References
AHADI, Tannaz; JAMKARANI, Maryam Esmaeili; RAISSI, Gholam Reza; MANSOORI, Korosh; RAZAVI, Seyede Zahra Emami; SAJADI, Simin. Prolotherapy vs Radial Extracorporeal Shock Wave Therapy in the Short-term Treatment of Lateral Epicondylosis: a randomized clinical trial. Pain Medicine, [S.L.], v. 20, n. 9, p. 1745-1749, 29 jan. 2019.
ARIAS-VÁZQUEZ, Pedro Iván; TOVILLA-ZÁRATE, Carlos Alfonso; CASTILLO-AVILA, Rosa Giannina; LEGORRETA-RAMÍREZ, Blanca Gabriela; LÓPEZ-NARVÁEZ, María Lilia; ARCILA-NOVELO, Russell; GONZÁLEZ-CASTRO, Thelma Beatriz. Hypertonic Dextrose Prolotherapy, an Alternative to Intra-Articular Injections With Hyaluronic Acid in the Treatment of Knee Osteoarthritis. American Journal Of Physical Medicine & Rehabilitation, [S.L.], v. 101, n. 9, p. 816-825, 18 nov. 2021.
BAE, Geonhyeong; KIM, Suyeon; LEE, Sangseok; LEE, Woo Yong; LIM, Yunhee. Prolotherapy for the patients with chronic musculoskeletal pain: systematic review and meta-analysis. Anesthesia And Pain Medicine, [S.L.], v. 16, n. 1, p. 81-95, 31 jan. 2021.
BERTRAND, Helene; REEVES, Kenneth Dean; BENNETT, Cameron J.; BICKNELL, Simon; CHENG, An-Lin. Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Archives Of Physical Medicine And Rehabilitation, [S.L.], v. 97, n. 1, p. 17-25, jan. 2016.
CHANG, Yu-Ju; CHANG, Feng-Hang; HOU, Peng-Hsuan; TSENG, Kai-Hsiang; LIN, Yen-Nung. Effects of Hyperosmolar Dextrose Injection in Patients With Rotator Cuff Disease and Bursitis: a randomized controlled trial. Archives Of Physical Medicine And Rehabilitation, [S.L.], v. 102, n. 2, p. 245-250, fev. 2021.
CHOU, Yen; CHIOU, Hong-Jen; WANG, Hsin-Kai; LAI, Yi-Chen. Ultrasound-guided dextrose injection treatment for chronic myofascial pain syndrome: a retrospective case series. Journal Of The Chinese Medical Association, [S.L.], v. 83, n. 9, p. 876-879, 29 abr. 2020.
CHUNG, Meng-Wu; HSU, Chih-Yang; CHUNG, Wen-Kuei; LIN, Yen-Nung. Effects of dextrose prolotherapy on tendinopathy, fasciopathy, and ligament injuries, fact or myth? Medicine, [S.L.], v. 99, n. 46, p. e23201, 13 nov. 2020.
COLE, Brandi; LAM, Patrick; HACKETT, Lisa; MURRELL, George A. C.. Ultrasound-guided injections for supraspinatus tendinopathy: corticosteroid versus glucose prolotherapy ⠳ a randomized controlled clinical trial. Shoulder & Elbow, [S.L.], v. 10, n. 3, p. 170-178, 5 jun. 2017.
CORTEZ, Vitor Santos; MORAES, Walter Augusto; TABA, João Victor; CONDI, Alberto; SUZUKI, Milena Oliveira; NASCIMENTO, Fernanda Sayuri do; PIPEK, Leonardo Zumerkorn; MATTOS, Vitoria Carneiro de; TORSANI, Matheus Belloni; MEYER, Alberto; HSING, Wu Tu; LUAMOTO, Leandro Ryuchi. Comparing dextrose prolotherapy with other substances in knee osteoarthritis pain relief: a systematic review. Clinics, [S.L.], v. 77, p. 100037, jan. 2022.
FRANCIO, Vinicius Tieppo; DIMA, Robert s; TOWERY, Chris; DAVANI, Saeid. Prolotherapy and Low Level Laser Therapy: a synergistic approach to pain management in chronic osteoarthritis. Anesthesiology And Pain Medicine, [S.L.], v. 7, n. 5, e14470, 15 out. 2017.
GIORDANO, Lorenzo; MURRELL, William D; MAFFULLI, Nicola. Prolotherapy for chronic low back pain: a review of literature. British Medical Bulletin, [S.L.], v. 138, n. 1, p. 96-111, 21 abr. 2021.
HAUSER, Ross A.; LACKNER, Johanna B.; STEILEN-MATIAS, Danielle; HARRIS, David K.. A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, [S.L.], v. 9, p. 139-159, jan. 2016.
JAHANGIRI, Azadeh; MOGHADDAM, Farid Rezaiee; NAJAFI, Sharif. Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint: a double-blind randomized clinical trial. Journal Of Orthopaedic Science, [S.L.], v. 19, n. 5, p. 737-743, set. 2014.
KESIKBURUN, Serdar; ŞAN, Ayca Uran; KESIKBURUN, Bilge; ARAS, Berke; YAşAR, Evren; TAN, Arif Kenan. Comparison of Ultrasound-Guided Prolotherapy Versus Extracorporeal Shock Wave Therapy in the Treatment of Chronic Plantar Fasciitis: a randomized clinical trial. The Journal Of Foot And Ankle Surgery, [S.L.], v. 61, n. 1, p. 48-52, jan. 2022.
LEONI, Héctor Tito; VILA, Francisco Olivero; AMOROSO, Andrés; LUPIA, Ana María; BOTARGUES, Marcela. Perineural infiltration technique (PIT) in complex wounds. Revista Argentina de Cirurgia Plástica, Buenos Aires, v. 26, n. 1, p. 9-16, mar. 2020.
LIN, Che-Li; HUANG, Chi-Chang; HUANG, Shih-Wei. Effects of hypertonic dextrose injection in chronic supraspinatus tendinopathy of the shoulder: a randomized placebo-controlled trial. European Journal Of Physical And Rehabilitation Medicine, [S.L.], v. 55, n. 4, p. 480-487, jul. 2019.
LIN, Che-Li; CHEN, Yi-Wen; WU, Chin-Wen; LIOU, Tsan-Hon; HUANG, Shih-Wei. Effect of Hypertonic Dextrose Injection on Pain and Shoulder Disability in Patients with Chronic Supraspinatus Tendinosis: a randomized double-blind controlled study. Archives Of Physical Medicine And Rehabilitation, [S.L.], v. 103, n. 2, p. 237-244, fev. 2022.
MANSIZ-KAPLAN, Basak; NACIR, Baris; PERVANE-VURAL, Secil; DUYUR-CAKIT, Burcu; GENC, Hakan. Effect of Dextrose Prolotherapy on Pain Intensity, Disability, and Plantar Fascia Thickness in Unilateral Plantar Fasciitis. American Journal Of Physical Medicine & Rehabilitation, [S.L.], v. 99, n. 4, p. 318-324, 15 nov. 2019.
NAIR, Abhijit. Prolotherapy as an intervention for chronic, refractory musculoskeletal pain. Saudi Journal Of Anaesthesia, [S.L.], v. 15, n. 4, p. 463, 2021.
RABAGO, D.; PATTERSON, J. J.; MUNDT, M.; KIJOWSKI, R.; GRETTIE, J.; SEGAL, N. A.; ZGIERSKA, A.. Dextrose Prolotherapy for Knee Osteoarthritis: a randomized controlled trial. The Annals Of Family Medicine, [S.L.], v. 11, n. 3, p. 229-237, 1 maio 2013.
RABAGO, David; MUNDT, Marlon; ZGIERSKA, Aleksandra; GRETTIE, Jessica. Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: long term outcomes. Complementary Therapies In Medicine, [S.L.], v. 23, n. 3, p. 388-395, jun. 2015.
RABAGO, David; NOURANI, Bobby. Prolotherapy for Osteoarthritis and Tendinopathy: a descriptive review. Current Rheumatology Reports, [S.L.], v. 19, n. 6, 8 mai. 2017.
RABAGO, David; REEVES, Kenneth Dean; DOHERTY, Mary P.; FLECK, Maelu. Prolotherapy for Musculoskeletal Pain and Disability in Low- and Middle-Income Countries. Physical Medicine And Rehabilitation Clinics Of North America, [S.L.], v. 30, n. 4, p. 775-786, nov. 2019.
RAHIMZADEH, Poupak; IMANI, Farnad; FAIZ, Seyed Hamid Reza; ENTEZARY, Saeid Reza; ZAMANABADI, Mahnaz Narimani; ALEBOUYEH, Mahmoud Reza. The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clinical Interventions In Aging, [S.L.], v. 13, p. 73-79, jan. 2018.
REEVES, Kenneth Dean; SIT, Regina WS; RABAGO, David P. Dextrose prolotherapy: a narrative review of basic science, clinical research, and best treatment recommendations. Physical Medicine and Rehabilitation Clinics, v. 27, n. 4, p. 783-823, 2016.
ROCHA, Aner Deanderson Xavier; ALFIERI, Fábio Marcon; SILVA, Natália Cristina de Oliveira Vargas. Prevalence of chronic pain and associated factors in a small town in southern Brazil. Brazilian Journal of Pain, São Paulo, v. 3, n. 4, p. 225-231, jul. 2021.
RODRIGUES, Ana Carolina; CUNHA, Ana Marcia Rodrigues; FORNI, José Eduardo Nogueira; DIAS, Lilian Andreia Chessa; CONDI, Paulo Rafael; MARTINS, Marielza Regina Ismael. Factors that influence the quality of life in neuropathic, musculoskeletal, and oncological pain. Brazilian Journal of Pain, São Paulo, v. 1, n. 4, p. 31-36, mar. 2021.
SARI, Aylin; EROGLU, Ali. Comparison of ultrasound-guided platelet-rich plasma, prolotherapy, and corticosteroid injections in rotator cuff lesions. Journal Of Back And Musculoskeletal Rehabilitation, v. 33, n. 3, p. 387-396, 21 mai. 2020.
SCHWAN, Josianna; SCLAFANI, Joseph; TAWFIK, Vivianne L.. Chronic Pain Management in the Elderly. Anesthesiology Clinics, [S.L.], v. 37, n. 3, p. 547-560, set. 2019.
SEENAUTH, Casey; INOUYE, Vance; LANGLAND, Jeffrey O. Dextrose Prolotherapy for Chronic Shoulder Pain: A Case Report. Alternative Therapies In Health And Medicine, Washington, v. 1, n. 24, p. 56-60, jan. 2018.
SERT, Alketa T.; SEN, Ekin I.; ESMAEILZADEH, Sina; OZCAN, Emel. The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: a randomized controlled study. The Journal of Alternative And Complementary Medicine, [S.L.], v. 26, n. 5, p. 409-417, 1 maio 2020.
SEVEN, M.M.; ERSEN, O.; AKPANCAR, S.; OZKAN, H.; TURKKAN, S.; YđLDđZ, Y.; KOCA, K.. Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions. Orthopaedics & Traumatology: Surgery & Research, [S.L.], v. 103, n. 3, p. 427-433, mai. 2017.
SOLMAZ, İlker; AKPANCAR, Serkan; ÖRSÇELIK, Aydan; YENER-KARASIMAV, Özlem; GÜL, Deniz. Dextrose injections for failed back surgery syndrome: a consecutive case series. European Spine Journal, [S.L.], v. 28, n. 7, p. 1610-1617, 21 maio 2019.
SWIEBODA, Paulina; FILIP, Rafal; PRYSTUBA, Andrzej; DROZD, Mariola. Assessment of pain: types, mechanism and treatment. Annals of Agricultural and Environmental Medicine, Lublin, v. 20, n. 1, p. 2-7, 2013.
TREEDE, Rolf-Detlef; RIEF, Winfried; BARKE, Antonia; AZIZ, Qasim; BENNETT, Michael I.; BENOLIEL, Rafael; COHEN, Milton; EVERS, Stefan; FINNERUP, Nanna B.; FIRST, Michael B; GIAMBERARDINO, Maria Adele; KAASA, Stein; KORWISI, Beatrice; KOSEK, Eva; LAVAND’HOMME, Patricia; NICHOLAS, Michael; PERROT, Serge; SCHOLZ, Joachim; SCHUNG, Stephan; SMITH, Blair H; SVENSSON, Peter; VLAEYEN, Johan W S; WANG, Shuu-Jiun. Chronic pain as a symptom or a disease: the iasp classification of chronic pain for the international classification of diseases (icd-11). Pain, [S.L.], v. 160, n. 1, p. 19-27, jan. 2019.
WEE, Tze Chao; NEO, Edmund Jin Rui; TAN, Yeow Leng. Dextrose prolotherapy in knee osteoarthritis: a systematic review and meta-analysis. Journal Of Clinical Orthopaedics And Trauma, [S.L.], v. 19, p. 108-117, ago. 2021.
YILDIRIM, Timur. Comparison of the Effectiveness of Prolotherapy and Facet Joint Injection in the Treatment of Chronic Low Back Pain: a retrospective study. Journal of Medical Sciences, [S.L.], v. 41, n. 1, p. 1-6, 2021.


