Moisturizing emulsion with Attalea speciosa (babassu) oil as an alternative treatment for cutaneous xerosis in leprosy

Authors

  • Michael Jackson Ferreira da Silva
  • Eloisa da Graça do Rosario Gonçalves
  • Maria Celia Pires Costa
  • Antonio Rafael da Silva

DOI:

https://doi.org/10.34119/bjhrv6n2-146

Keywords:

babassu, cutaneous xerosis, Leprosy, moisturizer

Abstract

This study investigated the moisturizing action of a topical emulsion containing babassu coconut almond oil in xerotic skin volunteers treated or undergoing leprosy treatment. A total of 20 volunteers (16 men and 4 women, with a mean age of 52.2 ± 15.3) with cutaneous xerosis performed the tests after signing the informed consent form. The research subjects were instructed to use the product under investigation (Attalea speciosa almond oil gel-cream formulation) 1 (one) once a day, in two 15-day cycles: first with the gel-cream formulation with babassu oil (treatment A) and the second with the gel-cream formulation without babassu oil (treatment B). The moisturizing emulsion did not significantly alter (p> 0.05) the xerotic skin pH of the volunteers, treatment A (11.6 ± 0.1), treatment B (8.8 ± 0.2) and control (11.4 ± 0.2) at week W7, when compared to week W15, treatment A (11.0 ± 0.4), treatment B (11.6 ± 0.1) and control (11.4 ± 0.2). Clinical evaluations showed the efficacy and good tolerability of topical emulsion in the hydration of xerotic skin. The biophysical evaluation of the moisturizing emulsion proved the significant improvement of skin moisture.

References

Rawlings AV, Matts PJ. Stratum Corneum Moisturization at the Molecular Level: An Update in Relation to the Dry Skin Cycle. J Invest Dermatol. junho de 2005;124(6):1099–110.

Parker J, Scharfbillig R, Jones S. Moisturisers for the treatment of foot xerosis: a systematic review. J Foot Ankle Res. dezembro de 2017;10(1):9.

Harding, Watkinson, Rawlings, Scott. Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci. fevereiro de 2000;22(1):21–52.

Danby SG, Brown K, Higgs-Bayliss T, et al. The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin. Skin Pharmacol Physiol. 2016;29(3):135–47.

Pons-Guiraud A. Dry skin in dermatology: a complex physiopathology. J Eur Acad Dermatol Venereol. setembro de 2007;21(s2):1–4.

Bonté F. Skin moisturization mechanisms: new data. Ann Pharm Fr. maio de 2011;69(3):135–41.

Boralevi F, Meledie N’Djong AP, Yao Yoboue P, et al. Regression of cutaneous xerosis with emollient treatment in sub-Saharan African patients. Int J Dermatol. abril de 2017;56(4):467–73.

Ademola J, Frazier C, Kim SJ, et al. Clinical Evaluation of 40% Urea and 12% Ammonium Lactate in the Treatment of Xerosis: Am J Clin Dermatol. 2002;3(3):217–22.

Gunt HB, Levy SB, Lutrario CA. Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control. J Drugs Dermatol JDD. 1o de julho de 2018;17(7):758–64.

Goulart IMB, Arbex GL, Carneiro MH, et al. Efeitos adversos da poliquimioterapia em pacientes com hanseníase: um levantamento de cinco anos em um Centro de Saúde da Universidade Federal de Uberlândia. Rev Soc Bras Med Trop. outubro de 2002;35(5):453–60.

Cruz RC da S, Bührer-Sékula S, Penna MLF, et al. Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients. An Bras Dermatol. dezembro de 2017;92(6):761–73.

Kalaaji AN, Wallo W. A randomized controlled clinical study to evaluate the effectiveness of an active moisturizing lotion with colloidal oatmeal skin protectant versus its vehicle for the relief of xerosis. J Drugs Dermatol JDD. outubro de 2014;13(10):1265–8.

Albuquerque MCG. Avaliação físico-química dos óleos de babaçu (Orbignya speciosa) e coco (Cocos nucifera) com elevado índice de acidez e dos ácidos graxos (C6 a C16). Sci Plena [Internet]. 25 de setembro de 2017 [citado 5 de abril de 2022];13(8). Disponível em: https://www.scientiaplena.org.br/sp/article/view/2975

Vinhal JO, Lima CF, Barbosa LCA. Analytical pyrolysis of the kernel and oil of babassu palm (Orbignya phalerata). J Anal Appl Pyrolysis. maio de 2014;107:73–81.

Urioste D, Castro MBA, Biaggio FC, et al. Síntese de padrões cromatográficos e estabelecimento de método para dosagem da composição de ésteres de ácidos graxos presentes no biodiesel a partir do óleo de babaçu. Quím Nova. 2008;31(2):407–12.

Silva Santos D, Gomes da Silva I, Lacerda Barbosa MDC, et al. Parâmetros de qualidade físico-química de óleos e análise morfométrica de frutos e sementes da espécie Orbignya phalerata Martius por região ecológica. Eclética Quím J. 5 de outubro de 2017;41(1):74.

Santos DS, Silva IG da, Araújo BQ, et al. Extraction and Evaluation of Fatty Acid Compositon of Orbignya phalerata Martius Oils (Arecaceae) from Maranhão State, Brazil. J Braz Chem Soc. 2013;24(2):355–62.

Silva MJF da, Rodrigues AM, Vieira IRS, et al. Development and characterization of a babassu nut oil-based moisturizing cosmetic emulsion with a high sun protection factor. RSC Adv. 2020;10(44):26268–76.

Golmohammadzadeh S, Mokhtari M, Jaafari MR. Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles. Braz J Pharm Sci. dezembro de 2012;48(4):683–90.

Flor J, Davolos MR, Correa MA. Protetores solares. Quím Nova. fevereiro de 2007;30(1):153–8.

Schalka S, Reis VMS dos. Fator de proteção solar: significado e controvérsias. An Bras Dermatol. junho de 2011;86(3):507–15.

Shim JH, Park JH, Lee JH, et al. Moisturizers are effective in the treatment of xerosis irrespectively from their particular formulation: results from a prospective, randomized, double-blind controlled trial. J Eur Acad Dermatol Venereol. fevereiro de 2016;30(2):276–81.

Nogueira A, Sidou F, Brocard S. Effect of a new moisturizing lotion on immediate and cumulative skin hydration: Two randomized, intra-individual, vehicle- and comparator-controlled studies. J Dermatol Treat. agosto de 2011;22(4):221–5.

Kikuchi K, Tagami H, the Japanese Cosmetic Scientist Task Force for Skin Care of Atopic Dermatitis. Noninvasive biophysical assessments of the efficacy of a moisturizing cosmetic cream base for patients with atopic dermatitis during different seasons. Br J Dermatol. maio de 2008;158(5):969–78.

Elias PM. The how, why and clinical importance of stratum corneum acidification. Exp Dermatol. novembro de 2017;26(11):999–1003.

Moncrieff G, Cork M, Lawton S, et al. Use of emollients in dry-skin conditions: consensus statement. Clin Exp Dermatol. abril de 2013;38(3):231–8; quiz 238.

Ali S, Yosipovitch G. Skin pH: From Basic SciencE to Basic Skin Care. Acta Derm Venereol. 2013;93(3):261–7.

Elias PM. Stratum corneum acidification: how and why? Exp Dermatol. março de 2015;24(3):179–80.

Gunathilake R, Schurer NY, Shoo BA, et al. pH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function. J Invest Dermatol. julho de 2009;129(7):1719–29.

Mauro T, Grayson S, Gao WN, et al. Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol Res. 4 de maio de 1998;290(4):215–22.

Behne MJ, Meyer JW, Hanson KM, et al. NHE1 Regulates the Stratum Corneum Permeability Barrier Homeostasis. J Biol Chem. dezembro de 2002;277(49):47399–406.

Choi EH, Man MQ, Xu P, et al. Stratum corneum acidification is impaired in moderately aged human and murine skin. J Invest Dermatol. dezembro de 2007;127(12):2847–56.

Man MQ, Xin SJ, Song SP, et al. Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population. Skin Pharmacol Physiol. 2009;22(4):190–9.

Leonardi GR, Gaspar LR, Campos PMBGM. Estudo da variação do pH da pele humana exposta à formulação cosmética acrescida ou não das vitaminas A, E ou de ceramida, por metodologia não invasiva. An Bras Dermatol. outubro de 2002;77(5):563–9.

van Smeden J, Bouwstra JA. Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients. Em: Agner T, organizador. Current Problems in Dermatology [Internet]. S. Karger AG; 2016 [citado 5 de abril de 2022]. p. 8–26. Disponível em: https://www.karger.com/Article/FullText/441540

Milan ALK, Milão D, Souto AA, et al. Estudo da hidratação da pele por emulsões cosméticas para xerose e sua estabilidade por reologia. Rev Bras Ciênc Farm. dezembro de 2007;43(4):649–57.

Barco D, Giménez-Arnau A. [Xerosis: a dysfunction of the epidermal barrier]. Actas Dermosifiliogr. novembro de 2008;99(9):671–82.

Oliveira AIT de, Mahmoud TS, Nascimento GNL do, et al. Chemical Composition and Antimicrobial Potential of Palm Leaf Extracts from Babaçu (Attalea speciosa ), Buriti ( Mauritia flexuosa ), and Macaúba ( Acrocomia aculeata ). Sci World J. 2016;2016:1–5.

Nolan K, Marmur E. Moisturizers: reality and the skin benefits. Dermatol Ther. junho de 2012;25(3):229–33.

Sousa Vieira IR, Silva Sales J, dos Santos Cerqueira-Coutinho C, et al. Development and in vivo evaluation of the moisturising potential of cosmetic formulations containing Babassu (Orbignya phalerata Martius) oily extract: Desenvolvimento e avaliação in vivo do potencial hidratante de formulações cosméticas contendo extrato oleoso de Babaçu (Orbignya phalerata Martius). J Biomed Biopharm Res. dezembro de 2017;14(2):204–19.

Downloads

Published

03/27/2023

How to Cite

DA SILVA , M. J. F.; GONÇALVES , E. da G. do R.; COSTA, M. C. P.; DA SILVA , A. R. Moisturizing emulsion with Attalea speciosa (babassu) oil as an alternative treatment for cutaneous xerosis in leprosy. Brazilian Journal of Health Review, [S. l.], v. 6, n. 2, p. 6285–6298, 2023. DOI: 10.34119/bjhrv6n2-146. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/58416. Acesso em: 18 oct. 2026.

Issue

Section

Original Papers